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GENE:
IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2)
i
Other names:
IDH2, Isocitrate Dehydrogenase (NADP(+)) 2, Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial, Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial, Isocitrate Dehydrogenase [NADP], Mitochondrial, Oxalosuccinate Decarboxylase, NADP(+)-Specific ICDH, ICD-M, IDH, IDP, MNADP-IDH, D2HGA2, IDHM, IDPM
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Entrez ID:
3418
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Guardant360® CDx (54)
MSK-IMPACT (21)
FoundationOne® Heme CDx (10)
Oncomine™ Dx Target Test (10)
Oncomine™ Pan-Cancer Cell-Free Assay (4)
Guardant360 TissueNext™ (2)
UW-Oncoplex™ (2)
Abbott RealTime IDH2 (1)
Archer® FusionPlex® Comprehensive Thyroid & Lung (CTL) Kit (1)
AML Express™
AVENIO Tumor Tissue CGP Kit
AVENIO Tumor Tissue Expanded Kit
AVENIO ctDNA Expanded Kit
Altera
AmoyDx® HANDLE Classic NGS Panel
AnchorAIM® 72 gene detection for individualized treatment of solid tumors
Archer® FusionPlex® Myeloid Kit
Archer® VariantPlex® Comprehensive Thyroid and Lung (CTL) kit
Archer® VariantPlex® Myeloid panel
Archer® VariantPlex® Solid Tumor Kit
Archer™ FusionPlex™ Core Solid Tumor Panel
Archer™ VARIANTPlex™ Complete Solid Tumor panel
Archer™ VARIANTPlex™ Lymphoma panel
Archer™ VARIANTPlex™ Pan Solid Tumor panel
Find It®
Follow It®
FusionPlex™ Pan-Heme panel
Idylla™ IDH1-2 Mutation Assay
InVisionSeq™
Labcorp® Plasma Complete™
LiquidHALLMARK®
LiquidPlex™
Myeloid Molecular Profile
NGS Targeted Hotspot Panel
NeoLAB® Solid Tumor Liquid Biopsy
Northstar Select™
OncoGuide™ NCC Oncopanel System
OncoKey™ SL 525 Plus Assay
OncoKey™ SL 60 Plus Assay
OncoPanel™ Assay
OncoSTRAT&GO
OncoScan™ CNV Plus Assay
Oncomine Focus Assay
Oncomine Myeloid Assay GX
Oncomine Precision Assay
Oncomine Tumor Mutation Load Assay
Oncomine™ Myeloid MRD Assays
OptiSeq™ Lung Cancer Panel
OptiSeq™ Pan-Cancer Gene Panel
SOPHiA DDM™ Myeloid Solution
SOPHiA DDM™ Solid Tumor Plus Solution
SOPHiA Myeloid Plus Solution
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StrataNGS™ Test
SureSeq™ Myeloid MRD Panel
SureSeq™ Pan-Myeloid Panel
Tempus xF Assay
TruSight Myeloid Sequencing Panel
TruSight Oncology Comprehensive
TruSight Tumor 170 Assay
VarMap™ Pan-Cancer NGS Panel
Vartrace® AML Panel
oncoReveal™ Core LBx
oncoReveal™ Multi-Cancer with CNV & RNA Fusion Panel
oncoReveal™ Solid Tumor v2 Panel
›
Associations
(133)
News
Trials
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IDH2 mutation
Acute Myelogenous Leukemia
IDH2 mutation
Acute Myelogenous Leukemia
enasidenib
Sensitive: A1 - Approval
enasidenib
Sensitive
:
A1
enasidenib
Sensitive: A1 - Approval
enasidenib
Sensitive
:
A1
IDH2 mutation
Oligodendroglioma
IDH2 mutation
Oligodendroglioma
vorasidenib
Sensitive: A1 - Approval
vorasidenib
Sensitive
:
A1
vorasidenib
Sensitive: A1 - Approval
vorasidenib
Sensitive
:
A1
IDH2 mutation
Astrocytoma
IDH2 mutation
Astrocytoma
vorasidenib
Sensitive: A1 - Approval
vorasidenib
Sensitive
:
A1
vorasidenib
Sensitive: A1 - Approval
vorasidenib
Sensitive
:
A1
IDH2 mutation
Acute Myelogenous Leukemia
IDH2 mutation
Acute Myelogenous Leukemia
venetoclax
Sensitive: A2 - Guideline
venetoclax
Sensitive
:
A2
venetoclax
Sensitive: A2 - Guideline
venetoclax
Sensitive
:
A2
IDH2 mutation + Chr del(1p) + Chr del(19q)
Oligodendroglioma
IDH2 mutation + Chr del(1p) + Chr del(19q)
Oligodendroglioma
temozolomide
Sensitive: A2 - Guideline
temozolomide
Sensitive
:
A2
temozolomide
Sensitive: A2 - Guideline
temozolomide
Sensitive
:
A2
IDH2 mutation + Chr del(1p) + Chr del(19q)
Oligodendroglioma
IDH2 mutation + Chr del(1p) + Chr del(19q)
Oligodendroglioma
bevacizumab
Sensitive: A2 - Guideline
bevacizumab
Sensitive
:
A2
bevacizumab
Sensitive: A2 - Guideline
bevacizumab
Sensitive
:
A2
IDH2 mutation + Chr del(1p) + Chr del(19q)
Oligodendroglioma
IDH2 mutation + Chr del(1p) + Chr del(19q)
Oligodendroglioma
carmustine
Sensitive: A2 - Guideline
carmustine
Sensitive
:
A2
carmustine
Sensitive: A2 - Guideline
carmustine
Sensitive
:
A2
IDH2 mutation + Chr del(1p) + Chr del(19q)
Oligodendroglioma
IDH2 mutation + Chr del(1p) + Chr del(19q)
Oligodendroglioma
lomustine
Sensitive: A2 - Guideline
lomustine
Sensitive
:
A2
lomustine
Sensitive: A2 - Guideline
lomustine
Sensitive
:
A2
IDH2 mutation + Chr del(1p) + Chr del(19q)
Oligodendroglioma
IDH2 mutation + Chr del(1p) + Chr del(19q)
Oligodendroglioma
Sensitive: A2 - Guideline
Sensitive
:
A2
Sensitive: A2 - Guideline
Sensitive
:
A2
IDH2 mutation
Astrocytoma
IDH2 mutation
Astrocytoma
cisplatin
Sensitive: A2 - Guideline
cisplatin
Sensitive
:
A2
cisplatin
Sensitive: A2 - Guideline
cisplatin
Sensitive
:
A2
IDH2 mutation
Astrocytoma
IDH2 mutation
Astrocytoma
carboplatin
Sensitive: A2 - Guideline
carboplatin
Sensitive
:
A2
carboplatin
Sensitive: A2 - Guideline
carboplatin
Sensitive
:
A2
IDH2 mutation
Astrocytoma
IDH2 mutation
Astrocytoma
etoposide IV
Sensitive: A2 - Guideline
etoposide IV
Sensitive
:
A2
etoposide IV
Sensitive: A2 - Guideline
etoposide IV
Sensitive
:
A2
IDH2 mutation
Astrocytoma
IDH2 mutation
Astrocytoma
bevacizumab
Sensitive: A2 - Guideline
bevacizumab
Sensitive
:
A2
bevacizumab
Sensitive: A2 - Guideline
bevacizumab
Sensitive
:
A2
IDH2 mutation
Astrocytoma
IDH2 mutation
Astrocytoma
carmustine
Sensitive: A2 - Guideline
carmustine
Sensitive
:
A2
carmustine
Sensitive: A2 - Guideline
carmustine
Sensitive
:
A2
IDH2 mutation
Astrocytoma
IDH2 mutation
Astrocytoma
lomustine
Sensitive: A2 - Guideline
lomustine
Sensitive
:
A2
lomustine
Sensitive: A2 - Guideline
lomustine
Sensitive
:
A2
IDH2 mutation
Astrocytoma
IDH2 mutation
Astrocytoma
Sensitive: A2 - Guideline
Sensitive
:
A2
Sensitive: A2 - Guideline
Sensitive
:
A2
IDH2 mutation
Astrocytoma
IDH2 mutation
Astrocytoma
temozolomide
Sensitive: A2 - Guideline
temozolomide
Sensitive
:
A2
temozolomide
Sensitive: A2 - Guideline
temozolomide
Sensitive
:
A2
IDH2 mutation + Chr del(1p) + Chr del(19q)
Oligodendroglioma
IDH2 mutation + Chr del(1p) + Chr del(19q)
Oligodendroglioma
cisplatin
Sensitive: A2 - Guideline
cisplatin
Sensitive
:
A2
cisplatin
Sensitive: A2 - Guideline
cisplatin
Sensitive
:
A2
IDH2 mutation + Chr del(1p) + Chr del(19q)
Oligodendroglioma
IDH2 mutation + Chr del(1p) + Chr del(19q)
Oligodendroglioma
carboplatin
Sensitive: A2 - Guideline
carboplatin
Sensitive
:
A2
carboplatin
Sensitive: A2 - Guideline
carboplatin
Sensitive
:
A2
IDH2 mutation + Chr del(1p) + Chr del(19q)
Oligodendroglioma
IDH2 mutation + Chr del(1p) + Chr del(19q)
Oligodendroglioma
etoposide IV
Sensitive: A2 - Guideline
etoposide IV
Sensitive
:
A2
etoposide IV
Sensitive: A2 - Guideline
etoposide IV
Sensitive
:
A2
IDH2 mutation + BRAF V600E
Astrocytoma
IDH2 mutation + BRAF V600E
Astrocytoma
vemurafenib + cobimetinib
Sensitive: A2 - Guideline
vemurafenib + cobimetinib
Sensitive
:
A2
vemurafenib + cobimetinib
Sensitive: A2 - Guideline
vemurafenib + cobimetinib
Sensitive
:
A2
IDH2 mutation + BRAF V600E
Astrocytoma
IDH2 mutation + BRAF V600E
Astrocytoma
trametinib + dabrafenib
Sensitive: A2 - Guideline
trametinib + dabrafenib
Sensitive
:
A2
trametinib + dabrafenib
Sensitive: A2 - Guideline
trametinib + dabrafenib
Sensitive
:
A2
IDH2 mutation + NTRK3 fusion
Astrocytoma
IDH2 mutation + NTRK3 fusion
Astrocytoma
entrectinib
Sensitive: A2 - Guideline
entrectinib
Sensitive
:
A2
entrectinib
Sensitive: A2 - Guideline
entrectinib
Sensitive
:
A2
IDH2 mutation + NTRK2 fusion
Astrocytoma
IDH2 mutation + NTRK2 fusion
Astrocytoma
entrectinib
Sensitive: A2 - Guideline
entrectinib
Sensitive
:
A2
entrectinib
Sensitive: A2 - Guideline
entrectinib
Sensitive
:
A2
IDH2 mutation + NTRK1 fusion
Astrocytoma
IDH2 mutation + NTRK1 fusion
Astrocytoma
entrectinib
Sensitive: A2 - Guideline
entrectinib
Sensitive
:
A2
entrectinib
Sensitive: A2 - Guideline
entrectinib
Sensitive
:
A2
IDH2 mutation + NTRK3 fusion
Astrocytoma
IDH2 mutation + NTRK3 fusion
Astrocytoma
larotrectinib
Sensitive: A2 - Guideline
larotrectinib
Sensitive
:
A2
larotrectinib
Sensitive: A2 - Guideline
larotrectinib
Sensitive
:
A2
IDH2 mutation + NTRK2 fusion
Astrocytoma
IDH2 mutation + NTRK2 fusion
Astrocytoma
larotrectinib
Sensitive: A2 - Guideline
larotrectinib
Sensitive
:
A2
larotrectinib
Sensitive: A2 - Guideline
larotrectinib
Sensitive
:
A2
IDH2 mutation + NTRK1 fusion
Astrocytoma
IDH2 mutation + NTRK1 fusion
Astrocytoma
larotrectinib
Sensitive: A2 - Guideline
larotrectinib
Sensitive
:
A2
larotrectinib
Sensitive: A2 - Guideline
larotrectinib
Sensitive
:
A2
IDH2 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E
Oligodendroglioma
IDH2 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E
Oligodendroglioma
vemurafenib + cobimetinib
Sensitive: A2 - Guideline
vemurafenib + cobimetinib
Sensitive
:
A2
vemurafenib + cobimetinib
Sensitive: A2 - Guideline
vemurafenib + cobimetinib
Sensitive
:
A2
IDH2 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E
Oligodendroglioma
IDH2 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E
Oligodendroglioma
trametinib + dabrafenib
Sensitive: A2 - Guideline
trametinib + dabrafenib
Sensitive
:
A2
trametinib + dabrafenib
Sensitive: A2 - Guideline
trametinib + dabrafenib
Sensitive
:
A2
IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK3 fusion
Oligodendroglioma
IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK3 fusion
Oligodendroglioma
entrectinib
Sensitive: A2 - Guideline
entrectinib
Sensitive
:
A2
entrectinib
Sensitive: A2 - Guideline
entrectinib
Sensitive
:
A2
IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK2 fusion
Oligodendroglioma
IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK2 fusion
Oligodendroglioma
entrectinib
Sensitive: A2 - Guideline
entrectinib
Sensitive
:
A2
entrectinib
Sensitive: A2 - Guideline
entrectinib
Sensitive
:
A2
^
^
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