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our Premium Content: News alerts, weekly reports and conference plannersTEST:SOPHiA DDM™ Solid Tumor Plus Solution
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News alerts, weekly reports and conference planners
Company:
Sophia GeneticsType:
Laboratory Developed Test
Related tests:
SOPHiA DDM™ Solid Tumor Plus Solution (STS+) targets DNA variants and RNA transcripts of fusion genes associated with solid tumors, including lung, colorectal, skin, and brain cancers. The DNA panel covers 42 genes including 6 unique loci to detect MSI status associated with colorectal cancer, and the RNA panel targets 137 clinically relevant gene fusions. Probe design is optimized to guarantee high on-target rate and coverage uniformity throughout the entire target regions.
Cancer:
Brain Cancer, Colorectal Cancer, Lung Cancer, Skin Cancer
Gene:
AKT1 (V-akt murine thymoma viral oncogene homolog 1), ALK (Anaplastic lymphoma kinase), BRAF (B-raf proto-oncogene), CDK4 (Cyclin-dependent kinase 4), CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), CTNNB1 (Catenin (cadherin-associated protein), beta 1)
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AKT1 (V-akt murine thymoma viral oncogene homolog 1), ALK (Anaplastic lymphoma kinase), BRAF (B-raf proto-oncogene), CDK4 (Cyclin-dependent kinase 4), CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), CTNNB1 (Catenin (cadherin-associated protein), beta 1), DDR2 (Discoidin domain receptor 2), DICER1 (Dicer 1 Ribonuclease III), EGFR (Epidermal growth factor receptor), ERBB4 (erb-b2 receptor tyrosine kinase 4), FBXW7 (F-Box And WD Repeat Domain Containing 7), FGFR1 (Fibroblast growth factor receptor 1), FGFR2 (Fibroblast growth factor receptor 2), FGFR3 (Fibroblast growth factor receptor 3), FOXL2 (Forkhead Box L2), GNA11 (G Protein Subunit Alpha 11), GNAQ (G Protein Subunit Alpha Q), GNAS (GNAS Complex Locus), HER-2 (Human epidermal growth factor receptor 2), HRAS (Harvey rat sarcoma viral oncogene homolog), IDH1 (Isocitrate dehydrogenase (NADP(+)) 1), IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), KIT (KIT proto-oncogene, receptor tyrosine kinase), KRAS (KRAS proto-oncogene GTPase), MAP2K1 (Mitogen-activated protein kinase kinase 1), MET (MET proto-oncogene, receptor tyrosine kinase), MYOD1 (Myogenic Differentiation 1), NRAS (Neuroblastoma RAS viral oncogene homolog), NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1), PDGFRA (Platelet Derived Growth Factor Receptor Alpha), PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha), PPARG (Peroxisome Proliferator Activated Receptor Gamma), PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), RAC1 (Rac Family Small GTPase 1), RAF1 (Raf-1 Proto-Oncogene Serine/Threonine Kinase), RET (Ret Proto-Oncogene), ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS), SF3B1 (Splicing Factor 3b Subunit 1), SMAD4 (SMAD family member 4), TERT (Telomerase Reverse Transcriptase), TP53 (Tumor protein P53)
Method:
Next-Generation Sequencing (NGS)
