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our Premium Content: News alerts, weekly reports and conference plannersTEST:Archer® FusionPlex® Myeloid Kit
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News alerts, weekly reports and conference planners
Company:
Integrated DNA TechnologiesType:
Laboratory Developed Test
Related tests:
The Archer® FusionPlex® Myeloid Kit is a targeted next-generation sequencing assay to detect and identify fusions, point mutations and expression levels from 84 genes associated with myeloid-origin malignancies. Studies are performed from RNA extracted from several types of starting sample. Using Archer’s proprietary Anchored Multiplex PCR (AMP™)-based enrichment, fusions of all genes in this kit can be identified in a single sequencing assay, even without prior knowledge of fusion partners or breakpoints.
Cancer:
Chronic Myeloid Leukemia
Gene:
ABL1 (ABL proto-oncogene 1), AKT3 (V-akt murine thymoma viral oncogene homolog 3), ASXL1 (ASXL Transcriptional Regulator 1), BCR (BCR Activator Of RhoGEF And GTPase), BRAF (B-raf proto-oncogene), CALR (Calreticulin)
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ABL1 (ABL proto-oncogene 1), AKT3 (V-akt murine thymoma viral oncogene homolog 3), ASXL1 (ASXL Transcriptional Regulator 1), BCR (BCR Activator Of RhoGEF And GTPase), BRAF (B-raf proto-oncogene), CALR (Calreticulin), CBFB (Core-Binding Factor Subunit Beta 2), CBL (Cbl proto-oncogene), CEBPA (CCAAT Enhancer Binding Protein Alpha), CHD1 (Chromodomain Helicase DNA Binding Protein 1), ETV6 (ETS Variant Transcription Factor 6), FGFR2 (Fibroblast growth factor receptor 2), FGFR3 (Fibroblast growth factor receptor 3), FLT3 (Fms-related tyrosine kinase 3), GATA1 (GATA Binding Protein 1), GATA2 (GATA Binding Protein 2), GLIS2 (GLIS Family Zinc Finger 2), GNAS (GNAS Complex Locus), IDH1 (Isocitrate dehydrogenase (NADP(+)) 1), IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), IKZF1 (IKAROS Family Zinc Finger 1), IKZF3 (IKAROS Family Zinc Finger 3), JAK1 (Janus Kinase 1), JAK2 (Janus kinase 2), JAK3 (Janus Kinase 3), MLLT10 (MLLT10 Histone Lysine Methyltransferase DOT1L Cofactor), MUC1 (Mucin 1), MYC (V-myc avian myelocytomatosis viral oncogene homolog), MYH11 (Myosin Heavy Chain 11), NF1 (Neurofibromin 1), NOTCH1 (Notch 1), NPM1 (Nucleophosmin 1), NRAS (Neuroblastoma RAS viral oncogene homolog), NUP214 (Nucleoporin 214), PDGFRA (Platelet Derived Growth Factor Receptor Alpha), PDGFRB (Platelet Derived Growth Factor Receptor Beta), PHF6 (PHD Finger Protein 6), PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), RARA (Retinoic Acid Receptor Alpha), ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS)
Method:
Next-Generation Sequencing (NGS)
