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our Premium Content: News alerts, weekly reports and conference plannersTEST:Archer® VariantPlex® Solid Tumor Kit
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News alerts, weekly reports and conference planners
Company:
Integrated DNA TechnologiesType:
Laboratory Developed Test
Related tests:
The Archer® VariantPlex® Solid Tumor Kit is a targeted sequencing assay that simultaneously detects and characterizes single nucleotide variants (SNVs), copy number variations (CNVs) and insertions and deletions (indels) in 67 genes associated with solid tumors. Apart from the Variantplex kit, ArcherDx has thorough product line of NGS Solid Tumor assays to detect various driver mutation types. This approach combines FusionPlex®, VariantPlex® and Reveal ctDNA™ kits to characterize gene fusions, expression, CNVs and other variants from a single, low-input FFPE sample and liquid biopsy.
Cancer:
Solid Tumor
Gene:
ABL1 (ABL proto-oncogene 1), AKT1 (V-akt murine thymoma viral oncogene homolog 1), ALK (Anaplastic lymphoma kinase), APC (APC Regulator Of WNT Signaling Pathway), ATM (ATM serine/threonine kinase), AURKA (Aurora kinase A)
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ABL1 (ABL proto-oncogene 1), AKT1 (V-akt murine thymoma viral oncogene homolog 1), ALK (Anaplastic lymphoma kinase), APC (APC Regulator Of WNT Signaling Pathway), ATM (ATM serine/threonine kinase), AURKA (Aurora kinase A), BRAF (B-raf proto-oncogene), CCND1 (Cyclin D1), CCNE1 (Cyclin E1), CDH1 (Cadherin 1), CDK4 (Cyclin-dependent kinase 4), CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), CSF1R (Colony stimulating factor 1 receptor), CTNNB1 (Catenin (cadherin-associated protein), beta 1), DDR2 (Discoidin domain receptor 2), EGFR (Epidermal growth factor receptor), ER (Estrogen receptor), ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3), ERBB4 (erb-b2 receptor tyrosine kinase 4), EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit), FBXW7 (F-Box And WD Repeat Domain Containing 7), FGFR1 (Fibroblast growth factor receptor 1), FGFR2 (Fibroblast growth factor receptor 2), FGFR3 (Fibroblast growth factor receptor 3), FLT3 (Fms-related tyrosine kinase 3), FOXL2 (Forkhead Box L2), GNA11 (G Protein Subunit Alpha 11), GNAQ (G Protein Subunit Alpha Q), GNAS (GNAS Complex Locus), HER-2 (Human epidermal growth factor receptor 2), HNF1A (HNF1 Homeobox A), HRAS (Harvey rat sarcoma viral oncogene homolog), IDH1 (Isocitrate dehydrogenase (NADP(+)) 1), IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), JAK2 (Janus kinase 2), JAK3 (Janus Kinase 3), KDR (Kinase insert domain receptor), KIT (KIT proto-oncogene, receptor tyrosine kinase), KRAS (KRAS proto-oncogene GTPase), MAP2K1 (Mitogen-activated protein kinase kinase 1), MDM2 (E3 ubiquitin protein ligase), MET (MET proto-oncogene, receptor tyrosine kinase), MYC (V-myc avian myelocytomatosis viral oncogene homolog), NOTCH1 (Notch 1), NPM1 (Nucleophosmin 1), NRAS (Neuroblastoma RAS viral oncogene homolog), PDGFRA (Platelet Derived Growth Factor Receptor Alpha), PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha), PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1), PTEN (Phosphatase and tensin homolog), PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), RB1 (RB Transcriptional Corepressor 1), RET (Ret Proto-Oncogene), RHOA (Ras homolog family member A), ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS), SMAD4 (SMAD family member 4), SMO (Smoothened Frizzled Class Receptor), SRC (SRC Proto-Oncogene), STK11 (Serine/threonine kinase 11), TERT (Telomerase Reverse Transcriptase), TP53 (Tumor protein P53), VHL (von Hippel-Lindau tumor suppressor)
Method:
Next-Generation Sequencing (NGS)
