TEST:

Abbott RealTime IDH2

Abbott RealTime IDH2 is an in vitro polymerase chain reaction (PCR) assay for the qualitative detection of single nucleotide variants (SNVs) coding nine IDH2 R140 and R172 mutations (R140Q, R140L, R140G, R140W, R172K, R172M, R172G, R172S, and R172W) in DNA extracted from human bone marrow (EDTA collection tubes) or blood (EDTA collection tubes). It is for use with the Abbott m2000rt System. Abbott RealTime IDH2 consists of two kits: Abbott RealTime IDH2 Amplification Reagent Kit, Abbott RealTime IDH2 Control Kit. It is indicated as an aid in identifying acute myeloid leukemia (AML) patients with an isocitrate dehydrogenase-2 (IDH2) mutation for treatment with IDHIFA® (enasidenib).