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our Premium Content: News alerts, weekly reports and conference plannersTEST:Myeloid Molecular Profile
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Company:
NeoGenomicsType:
Laboratory Developed Test
Related tests:
The Myeloid Molecular Profile detects mutations in key genes recurrently mutated in myeloid malignancies. Genomic DNA is isolated from bone marrow aspirates or peripheral blood and the DNA sequence of targeted regions of the ASXL1, BCOR, BRAF, CALR, CBL, CEBPA, CSF3R, DDX41, DNMT3A, ETNK1, ETV6, EZH2, GATA2, GNAS, GNB1, IDH1, IDH2, JAK2, KIT, KRAS, MPL, NF1, NPM1, NRAS, PDGFRA, PHF6, PPM1D, PTPN11, RAD21, RUNX1, SETBP1, SF3B1, SH2B3, SMC1A, SMC3, SRSF2, STAG2, STAT3, STAT5B, TET2, TP53, U2AF1, WT1, ZRSR2 genes is determined using next-generation sequencing (NGS) technology.
Cancer:
Acute Myelogenous Leukemia, Myelodysplastic Syndrome
Gene:
ASXL1 (ASXL Transcriptional Regulator 1), BRAF (B-raf proto-oncogene), CBL (Cbl proto-oncogene), CEBPA (CCAAT Enhancer Binding Protein Alpha), CSF3R (Colony Stimulating Factor 3 Receptor), DNMT3A (DNA methyltransferase 1)
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ASXL1 (ASXL Transcriptional Regulator 1), BRAF (B-raf proto-oncogene), CBL (Cbl proto-oncogene), CEBPA (CCAAT Enhancer Binding Protein Alpha), CSF3R (Colony Stimulating Factor 3 Receptor), DNMT3A (DNA methyltransferase 1), ETV6 (ETS Variant Transcription Factor 6), EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit), GNAS (GNAS Complex Locus), IDH1 (Isocitrate dehydrogenase (NADP(+)) 1), IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), JAK2 (Janus kinase 2), KIT (KIT proto-oncogene, receptor tyrosine kinase), KRAS (KRAS proto-oncogene GTPase), NF1 (Neurofibromin 1), NPM1 (Nucleophosmin 1), NRAS (Neuroblastoma RAS viral oncogene homolog), PDGFRA (Platelet Derived Growth Factor Receptor Alpha), PPM1D (Protein Phosphatase Mg2+/Mn2+ Dependent 1D), SETBP1 (SET Binding Protein 1), SF3B1 (Splicing Factor 3b Subunit 1), SH2B3 (SH2B Adaptor Protein 3), SRSF2 (Serine and arginine rich splicing factor 2), STAG2 (Stromal Antigen 2), STAT3 (Signal Transducer And Activator Of Transcription 3), STAT5B (Signal Transducer And Activator Of Transcription 5B), TET2 (Tet Methylcytosine Dioxygenase 2), TP53 (Tumor protein P53), U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1), WT1 (WT1 Transcription Factor)
Method:
Next-Generation Sequencing (NGS)
