TEST:

Oncomine Tumor Mutation Load Assay

ABL1 (ABL proto-oncogene 1), AKT1 (V-akt murine thymoma viral oncogene homolog 1), ALK (Anaplastic lymphoma kinase), AR (Androgen receptor), ARID1A (AT-rich interaction domain 1A), ASXL1 (ASXL Transcriptional Regulator 1), ATM (ATM serine/threonine kinase), BRAF (B-raf proto-oncogene), CCND1 (Cyclin D1), CDK12 (Cyclin dependent kinase 12), CDK4 (Cyclin-dependent kinase 4), CDK6 (Cyclin-dependent kinase 6), CHEK1 (Checkpoint kinase 1), CHEK2 (Checkpoint kinase 2), DNMT3A (DNA methyltransferase 1), EGFR (Epidermal growth factor receptor), ER (Estrogen receptor), ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3), ERBB4 (erb-b2 receptor tyrosine kinase 4), EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit), FANCA (FA Complementation Group A), FGFR1 (Fibroblast growth factor receptor 1), FGFR2 (Fibroblast growth factor receptor 2), FGFR3 (Fibroblast growth factor receptor 3), FGFR4 (Fibroblast growth factor receptor 4), FLT3 (Fms-related tyrosine kinase 3), HER-2 (Human epidermal growth factor receptor 2), HRAS (Harvey rat sarcoma viral oncogene homolog), IDH1 (Isocitrate dehydrogenase (NADP(+)) 1), IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), JAK2 (Janus kinase 2), KRAS (KRAS proto-oncogene GTPase), MAP2K1 (Mitogen-activated protein kinase kinase 1), MAP2K2 (Mitogen-activated protein kinase kinase 2), MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4), MAPK1 (Mitogen-activated protein kinase 1), MYC (V-myc avian myelocytomatosis viral oncogene homolog), NOTCH1 (Notch 1), NOTCH2 (Notch 2), NPM1 (Nucleophosmin 1), NRAS (Neuroblastoma RAS viral oncogene homolog), NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3), PALB2 (Partner and localizer of BRCA2), PIK3CB (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta), PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1), PTCH1 (Patched 1), PTEN (Phosphatase and tensin homolog), PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), RET (Ret Proto-Oncogene), ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS), RUNX1 (RUNX Family Transcription Factor 1), SF3B1 (Splicing Factor 3b Subunit 1), SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4), SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1), SMO (Smoothened Frizzled Class Receptor), STK11 (Serine/threonine kinase 11), TET2 (Tet Methylcytosine Dioxygenase 2), TMB (Tumor Mutational Burden), TP53 (Tumor protein P53), TSC1 (TSC complex subunit 1), TSC2 (TSC complex subunit 2), mTOR (Mechanistic target of rapamycin kinase)