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our Premium Content: News alerts, weekly reports and conference plannersTEST:AmoyDx® HANDLE Classic NGS Panel
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Company:
Amoy DiagnosticsType:
Laboratory Developed Test
Related tests:
The AmoyDx® HANDLE Classic NGS Panel is a next-generation sequencing (NGS) based in vitro diagnostic assay intended for qualitative detection of single nucleotide variants (SNVs), insertions and deletions (InDels), gene fusions, copy number amplifications (CNAs) and microsatellite instability (MSI) in 40 key solid tumour genes, using DNA and RNA isolated from formalin-fixed paraffin embedded (FFPE) tumour tissue specimens. The assay is intended to provide tumor mutation profiling to be used by qualified health care professionals in accordance with professional guidelines in oncology for patients with solid malignant neoplasms.
Cancer:
Solid Tumor
Gene:
AKT1 (V-akt murine thymoma viral oncogene homolog 1), ALK (Anaplastic lymphoma kinase), BRAF (B-raf proto-oncogene), CDK4 (Cyclin-dependent kinase 4), CTNNB1 (Catenin (cadherin-associated protein), beta 1), DDR2 (Discoidin domain receptor 2)
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AKT1 (V-akt murine thymoma viral oncogene homolog 1), ALK (Anaplastic lymphoma kinase), BRAF (B-raf proto-oncogene), CDK4 (Cyclin-dependent kinase 4), CTNNB1 (Catenin (cadherin-associated protein), beta 1), DDR2 (Discoidin domain receptor 2), DPYD (Dihydropyrimidine Dehydrogenase), EGFR (Epidermal growth factor receptor), ER (Estrogen receptor), FGFR1 (Fibroblast growth factor receptor 1), FGFR2 (Fibroblast growth factor receptor 2), FGFR3 (Fibroblast growth factor receptor 3), FGFR4 (Fibroblast growth factor receptor 4), HER-2 (Human epidermal growth factor receptor 2), HRAS (Harvey rat sarcoma viral oncogene homolog), IDH1 (Isocitrate dehydrogenase (NADP(+)) 1), IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), KEAP1 (Kelch Like ECH Associated Protein 1), KIT (KIT proto-oncogene, receptor tyrosine kinase), KRAS (KRAS proto-oncogene GTPase), MAP2K1 (Mitogen-activated protein kinase kinase 1), MET (MET proto-oncogene, receptor tyrosine kinase), MYC (V-myc avian myelocytomatosis viral oncogene homolog), NFE2L2 (Nuclear Factor, Erythroid 2 Like 2), NKX2-1 (NK2 Homeobox 1), NRAS (Neuroblastoma RAS viral oncogene homolog), NRG1 (Neuregulin 1), NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1), NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2), NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3), PDGFRA (Platelet Derived Growth Factor Receptor Alpha), PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha), POLE (DNA Polymerase Epsilon), PTEN (Phosphatase and tensin homolog), RB1 (RB Transcriptional Corepressor 1), RET (Ret Proto-Oncogene), ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS), STK11 (Serine/threonine kinase 11), TP53 (Tumor protein P53), UGT1A1 (UDP glucuronosyltransferase family 1 member A1)
Method:
Next-Generation Sequencing (NGS)
