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our Premium Content: News alerts, weekly reports and conference plannersTEST:UW-Oncoplex™
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Company:
University of WashingtonType:
Laboratory Developed Test
Related tests:
UW-OncoPlex™ is a multiplexed mutation assay for tumor tissue that assesses mutations >350 genes related to cancer treatment, prognosis, or diagnosis. The test uses next-generation "deep" sequencing to detect most classes of mutations, including single nucleotide variants, small insertions and deletions (indels), gene amplifications, and selected gene-fusions.
Cancer:
Leukemia, Lung Cancer, Melanoma, Prostate Cancer, Sarcoma
Gene:
ABL1 (ABL proto-oncogene 1), AKT1 (V-akt murine thymoma viral oncogene homolog 1), APC (APC Regulator Of WNT Signaling Pathway), ARID1A (AT-rich interaction domain 1A), ARID1B (AT-Rich Interaction Domain 1B), ATM (ATM serine/threonine kinase)
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ABL1 (ABL proto-oncogene 1), AKT1 (V-akt murine thymoma viral oncogene homolog 1), APC (APC Regulator Of WNT Signaling Pathway), ARID1A (AT-rich interaction domain 1A), ARID1B (AT-Rich Interaction Domain 1B), ATM (ATM serine/threonine kinase), ATR (Ataxia telangiectasia and Rad3-related protein), AURKA (Aurora kinase A), BAP1 (BRCA1 Associated Protein 1), BCL2 (B-cell CLL/lymphoma 2), BRCA1 (Breast cancer 1, early onset), CCND1 (Cyclin D1), CD4 (CD4 Molecule), CD8 (cluster of differentiation 8), DDR2 (Discoidin domain receptor 2), EGFR (Epidermal growth factor receptor), ERBB4 (erb-b2 receptor tyrosine kinase 4), FLT3 (Fms-related tyrosine kinase 3), FOXP3 (Forkhead Box P3), GATA1 (GATA Binding Protein 1), GNA11 (G Protein Subunit Alpha 11), GNAQ (G Protein Subunit Alpha Q), HER-2 (Human epidermal growth factor receptor 2), IDH1 (Isocitrate dehydrogenase (NADP(+)) 1), IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), JAK1 (Janus Kinase 1), KRAS (KRAS proto-oncogene GTPase), MSI (Microsatellite instability), NRAS (Neuroblastoma RAS viral oncogene homolog), PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha), TMB (Tumor Mutational Burden), TP53 (Tumor protein P53), mTOR (Mechanistic target of rapamycin kinase)
Method:
Next-Generation Sequencing (NGS)
