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our Premium Content: News alerts, weekly reports and conference plannersTEST:SOPHiA DDM™ Myeloid Solution
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News alerts, weekly reports and conference planners
Company:
Sophia GeneticsType:
Laboratory Developed Test
Related tests:
SOPHiA GENETICS™ Myeloid Solution covers 30 relevant genes (10 with complete coding sequences) associated with myelodysplastic syndromes, myeloproliferative neoplasms, and leukemia. Probe design is optimized to guarantee high on-target rate and coverage uniformity even in GC-rich regions. The technical limitations related to the analyses of key biomarkers such as CEBPA, ASXL1, CALR and FLT3 (including detection of internal tandem duplications) are addressed.
Cancer:
Leukemia, Myelodysplastic Syndrome, Myeloproliferative Neoplasm
Gene:
ABL1 (ABL proto-oncogene 1), ASXL1 (ASXL Transcriptional Regulator 1), BRAF (B-raf proto-oncogene), CALR (Calreticulin), CBL (Cbl proto-oncogene), CEBPA (CCAAT Enhancer Binding Protein Alpha)
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ABL1 (ABL proto-oncogene 1), ASXL1 (ASXL Transcriptional Regulator 1), BRAF (B-raf proto-oncogene), CALR (Calreticulin), CBL (Cbl proto-oncogene), CEBPA (CCAAT Enhancer Binding Protein Alpha), CSF3R (Colony Stimulating Factor 3 Receptor), DNMT3A (DNA methyltransferase 1), ETV6 (ETS Variant Transcription Factor 6), EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit), FLT3 (Fms-related tyrosine kinase 3), HRAS (Harvey rat sarcoma viral oncogene homolog), IDH1 (Isocitrate dehydrogenase (NADP(+)) 1), IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), JAK2 (Janus kinase 2), KIT (KIT proto-oncogene, receptor tyrosine kinase), KRAS (KRAS proto-oncogene GTPase), MPL (MPL Proto-Oncogene, Thrombopoietin Receptor), NPM1 (Nucleophosmin 1), NRAS (Neuroblastoma RAS viral oncogene homolog), PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), RUNX1 (RUNX Family Transcription Factor 1), SETBP1 (SET Binding Protein 1), SF3B1 (Splicing Factor 3b Subunit 1), SRSF2 (Serine and arginine rich splicing factor 2), TET2 (Tet Methylcytosine Dioxygenase 2), TP53 (Tumor protein P53), U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1), WT1 (WT1 Transcription Factor), ZRSR2 (Zinc Finger CCCH-Type, RNA Binding Motif And Serine/Arginine Rich 2)
Method:
Next-Generation Sequencing (NGS)
