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our Premium Content: News alerts, weekly reports and conference plannersTEST:oncoReveal™ Core LBx
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Company:
Pillar BiosciType:
Laboratory Developed Test
Related tests:
The oncoReveal Core LBx panel is a robust NGS assay that interrogates 104 genes of interest across
multiple solid tumor cancer types. The panel is specifically designed for cell-free DNA (cfDNA). The assay uses proprietary Stem-Loop Inhibition-Mediated amplification (SLIMamp®) technology, a tiled amplicon-based library prep chemistry for efficient single-tube target enrichment.
Cancer:
Solid Tumor
Gene:
AKT1 (V-akt murine thymoma viral oncogene homolog 1), ALK (Anaplastic lymphoma kinase), APC (APC Regulator Of WNT Signaling Pathway), AR (Androgen receptor), ARAF (A-Raf Proto-Oncogene), ARID1A (AT-rich interaction domain 1A)
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AKT1 (V-akt murine thymoma viral oncogene homolog 1), ALK (Anaplastic lymphoma kinase), APC (APC Regulator Of WNT Signaling Pathway), AR (Androgen receptor), ARAF (A-Raf Proto-Oncogene), ARID1A (AT-rich interaction domain 1A), ARID2 (AT-Rich Interaction Domain 2), ASXL1 (ASXL Transcriptional Regulator 1), ATM (ATM serine/threonine kinase), ATRX (ATRX Chromatin Remodeler), AXIN2 (Axin 2), AXL (AXL Receptor Tyrosine Kinase), B2M (Beta-2-microglobulin), BCOR (BCL6 Corepressor), BRAF (B-raf proto-oncogene), CARD11 (Caspase Recruitment Domain Family Member 11), CCND1 (Cyclin D1), CDH1 (Cadherin 1), CDK4 (Cyclin-dependent kinase 4), CDK6 (Cyclin-dependent kinase 6), CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), CIC (Capicua Transcriptional Repressor), CREBBP (CREB binding protein), CTNNB1 (Catenin (cadherin-associated protein), beta 1), EGFR (Epidermal growth factor receptor), EP300 (E1A binding protein p300), ER (Estrogen receptor), ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3), EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit), FBXW7 (F-Box And WD Repeat Domain Containing 7), FGFR1 (Fibroblast growth factor receptor 1), FGFR2 (Fibroblast growth factor receptor 2), FGFR3 (Fibroblast growth factor receptor 3), FLCN (Folliculin), FOXL2 (Forkhead Box L2), GATA3 (GATA binding protein 3), GLI1 (GLI Family Zinc Finger 1), GNA11 (G Protein Subunit Alpha 11), GNAQ (G Protein Subunit Alpha Q), GNAS (GNAS Complex Locus), HER-2 (Human epidermal growth factor receptor 2), HNF1A (HNF1 Homeobox A), HRAS (Harvey rat sarcoma viral oncogene homolog), IDH1 (Isocitrate dehydrogenase (NADP(+)) 1), IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), IKZF1 (IKAROS Family Zinc Finger 1), JAK1 (Janus Kinase 1), KDM5A (Lysine Demethylase 5A), KIT (KIT proto-oncogene, receptor tyrosine kinase), KRAS (KRAS proto-oncogene GTPase), MAP2K1 (Mitogen-activated protein kinase kinase 1), MAP2K2 (Mitogen-activated protein kinase kinase 2), MAPK1 (Mitogen-activated protein kinase 1), MED12 (Mediator Complex Subunit 12), MET (MET proto-oncogene, receptor tyrosine kinase), MLH1 (MutL homolog 1), MLL2 (Myeloid/lymphoid or mixed-lineage leukemia 2), MRE11A (MRE11 homolog, double strand break repair nuclease), MSH6 (MutS homolog 6), MYC (V-myc avian myelocytomatosis viral oncogene homolog), MYOD1 (Myogenic Differentiation 1), NCOR1 (Nuclear Receptor Corepressor 1), NF1 (Neurofibromin 1), NFE2L2 (Nuclear Factor, Erythroid 2 Like 2), NOTCH1 (Notch 1), NRAS (Neuroblastoma RAS viral oncogene homolog), NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1), NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3), PDGFRA (Platelet Derived Growth Factor Receptor Alpha), PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha), PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1), POLE (DNA Polymerase Epsilon), PPP2R1A (Protein Phosphatase 2 Scaffold Subunit Aalpha), PTCH1 (Patched 1), PTEN (Phosphatase and tensin homolog), PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), PTPRD (Protein tyrosine phosphatase receptor type D), RAC1 (Rac Family Small GTPase 1), RAF1 (Raf-1 Proto-Oncogene Serine/Threonine Kinase), RB1 (RB Transcriptional Corepressor 1), RET (Ret Proto-Oncogene), RHEB (Ras Homolog, MTORC1 Binding), RHOA (Ras homolog family member A), RIT1 (Ras Like Without CAAX 1), RNF43 (Ring Finger Protein 43), ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS), RUNX1 (RUNX Family Transcription Factor 1), SF3B1 (Splicing Factor 3b Subunit 1), SMAD4 (SMAD family member 4), SMO (Smoothened Frizzled Class Receptor), SOX9 (SRY-Box Transcription Factor 9), SPOP (Speckle Type BTB/POZ Protein), STAT5B (Signal Transducer And Activator Of Transcription 5B), STK11 (Serine/threonine kinase 11), TCF7L2 (Transcription Factor 7 Like 2), TP53 (Tumor protein P53), TSC1 (TSC complex subunit 1), U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1), VHL (von Hippel-Lindau tumor suppressor), mTOR (Mechanistic target of rapamycin kinase)
Method:
Next-Generation Sequencing (NGS)
