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our Premium Content: News alerts, weekly reports and conference plannersTEST:AML Express™
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Company:
NeoGenomicsType:
Laboratory Developed Test
Related tests:
AML Express assay is a next-generation sequencing (NGS) assay using combined DNA and RNA sequencing, which is used to identify prognostically and diagnostically informative alterations in acute myeloid leukemia (AML). The DNA sequencing component of this assay detects single nucleotide variants (SNVs) and indels in genes recurrently mutated in AML, and the RNA sequencing component detects fusions involving genes that are frequently involved in structural rearrangements observed in AML, as noted below.
Cancer:
Acute Myelogenous Leukemia
Gene:
ABL1 (ABL proto-oncogene 1), ASXL1 (ASXL Transcriptional Regulator 1), BCOR (BCL6 Corepressor), BRAF (B-raf proto-oncogene), CALR (Calreticulin), CBL (Cbl proto-oncogene)
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ABL1 (ABL proto-oncogene 1), ASXL1 (ASXL Transcriptional Regulator 1), BCOR (BCL6 Corepressor), BRAF (B-raf proto-oncogene), CALR (Calreticulin), CBL (Cbl proto-oncogene), CEBPA (CCAAT Enhancer Binding Protein Alpha), CSF3R (Colony Stimulating Factor 3 Receptor), DDX41 (DEAD-Box Helicase 41), DNMT3A (DNA methyltransferase 1), ETV6 (ETS Variant Transcription Factor 6), EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit), FLT3 (Fms-related tyrosine kinase 3), GATA2 (GATA Binding Protein 2), HRAS (Harvey rat sarcoma viral oncogene homolog), IDH1 (Isocitrate dehydrogenase (NADP(+)) 1), IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), JAK2 (Janus kinase 2), KAT6A (Lysine Acetyltransferase 6A), KIT (KIT proto-oncogene, receptor tyrosine kinase), KRAS (KRAS proto-oncogene GTPase), MECOM (MDS1 And EVI1 Complex Locus), MPL (MPL Proto-Oncogene, Thrombopoietin Receptor), MYH11 (Myosin Heavy Chain 11), NF1 (Neurofibromin 1), NPM1 (Nucleophosmin 1), NRAS (Neuroblastoma RAS viral oncogene homolog), NUP214 (Nucleoporin 214), NUP98 (Nucleoporin 98 And 96 Precursor 2), PHF6 (PHD Finger Protein 6), PPM1D (Protein Phosphatase Mg2+/Mn2+ Dependent 1D), PRPF8 (Pre-MRNA Processing Factor 8), PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), RUNX1 (RUNX Family Transcription Factor 1), SETBP1 (SET Binding Protein 1), SF3B1 (Splicing Factor 3b Subunit 1), SRSF2 (Serine and arginine rich splicing factor 2), STAG2 (Stromal Antigen 2), TET2 (Tet Methylcytosine Dioxygenase 2), TP53 (Tumor protein P53), U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1), WT1 (WT1 Transcription Factor), ZRSR2 (Zinc Finger CCCH-Type, RNA Binding Motif And Serine/Arginine Rich 2)
Method:
Next-Generation Sequencing
