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BIOMARKER:

NPM1 mutation + FLT3-TKD mutation

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Entrez ID:

Related biomarkers:

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FLT3-ITD mutation (90)

FLT3 mutation (67)

NPM1 mutation (42)

FLT3-TKD mutation (13)

FLT3 D835Y (12)

FLT3 F691L (11)

FLT3-ITD mutation + FLT3-TKD mutation (5)

DNMT3A mutation + FLT3-ITD mutation (4)

FLT3 mutation + NPM1 mutation (4)

FLT3 N676D + FLT3 Y842C (3)

FLT3 mutation + DNMT3A mutation (3)

FLT3 mutation + NRAS mutation (3)

FLT3 wild-type (3)

FLT3-ITD mutation + FLT3 D835 (3)

FLT3-ITD mutation + MLL rearrangement (3)

FLT3-ITD mutation + NPM1 mutation (3)

FLT3‐ITD + NPM1 mutation (3)

FLT3‐ITD mutation + DNMT3A mutation + NPM1 mutation (3)

FLT3 mutation + MLL mutation (2)

FLT3-ITD mutation + FLT3 D835Y (2)

FLT3-ITD mutation + FLT3 F691L (2)

FLT3-ITD mutation + IDH1 mutation (2)

FLT3-ITD mutation + IDH2 mutation (2)

FLT3-ITD mutation + WT1 mutation (2)

DNMT3A mutation + NPM1 mutation (2)

NPM1 mutation + DNMT3A mutation (2)

CEBPZ rearrangement + FLT3-TKD mutation (1)

FLT3 E588_Y589INSKYFYVDFRE (1)

FLT3 F691L + FLT3 D835F (1)

FLT3 F691L + FLT3 D835H (1)

FLT3 F691L + FLT3 D835V (1)

FLT3 F691L + FLT3 D835Y (1)

FLT3 F691L + FLT3 D839G (1)

FLT3 F691L + FLT3 Y842C (1)

FLT3 NPOS + FLT3 D835N (1)

FLT3 V592A + FLT3 D835N (1)

FLT3 V592_D593INSDFREY (1)

FLT3 Y591_V592INSVDFREYE (1)

FLT3 mutation + IDH1 mutation (1)

FLT3 mutation + NRAS mutation + PTPN11 mutation (1)

FLT3 mutation + PTPN11 mutation (1)

FLT3 positive (1)

FLT3-ITD F692L + NPM1 mutation (1)

FLT3-ITD mutation + ASXL1 mutation (1)

FLT3-ITD mutation + ASXL1 mutation + NRAS mutation (1)

FLT3-ITD mutation + DNMT3A mutation + ASXL1 mutation (1)

FLT3-ITD mutation + DNMT3A mutation + NRAS mutation (1)

FLT3-ITD mutation + FLT3 D835Y + FLT3 F691L (1)

FLT3-ITD mutation + NRAS mutation + GATA2 mutation (1)

FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

FLT3‐ITD + DNMT3A mutation (1)

FLT3‐ITD + WT1 mutation (1)

MLL rearrangement + FLT3 mutation (1)

NPM1 mutation + FLT3-ITD mutation + TET2 mutation + CUX1 mutation (1)

NPM1 mutation + SRSF2 mutation + FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

IDH2 R140Q + NPM1 mutation (1)

IDH2 mutation + NPM1 mutation (1)

NPM1 exon 11 mutation (1)

NPM1 mutation + DNMT3A mutation + KMT2D mutation (1)

NPM1 mutation + NRAS mutation (1)

NPM1 mutation + SRSF2 mutation (1)

FLT3 F691L + FLT3 Y842H (0)

FLT3-ITD F692L (0)

PTPN11 mutation + NPM1 mutation (0)

FLT3-ITD mutation (90)

FLT3 mutation (67)

NPM1 mutation (42)

FLT3-TKD mutation (13)

FLT3 D835Y (12)

FLT3 F691L (11)

FLT3-ITD mutation + FLT3-TKD mutation (5)

DNMT3A mutation + FLT3-ITD mutation (4)

FLT3 mutation + NPM1 mutation (4)

FLT3 N676D + FLT3 Y842C (3)

FLT3 mutation + DNMT3A mutation (3)

FLT3 mutation + NRAS mutation (3)

FLT3 wild-type (3)

FLT3-ITD mutation + FLT3 D835 (3)

FLT3-ITD mutation + MLL rearrangement (3)

FLT3-ITD mutation + NPM1 mutation (3)

FLT3‐ITD + NPM1 mutation (3)

FLT3‐ITD mutation + DNMT3A mutation + NPM1 mutation (3)

FLT3 mutation + MLL mutation (2)

FLT3-ITD mutation + FLT3 D835Y (2)

FLT3-ITD mutation + FLT3 F691L (2)

FLT3-ITD mutation + IDH1 mutation (2)

FLT3-ITD mutation + IDH2 mutation (2)

FLT3-ITD mutation + WT1 mutation (2)

DNMT3A mutation + NPM1 mutation (2)

NPM1 mutation + DNMT3A mutation (2)

CEBPZ rearrangement + FLT3-TKD mutation (1)

FLT3 E588_Y589INSKYFYVDFRE (1)

FLT3 F691L + FLT3 D835F (1)

FLT3 F691L + FLT3 D835H (1)

FLT3 F691L + FLT3 D835V (1)

FLT3 F691L + FLT3 D835Y (1)

FLT3 F691L + FLT3 D839G (1)

FLT3 F691L + FLT3 Y842C (1)

FLT3 NPOS + FLT3 D835N (1)

FLT3 V592A + FLT3 D835N (1)

FLT3 V592_D593INSDFREY (1)

FLT3 Y591_V592INSVDFREYE (1)

FLT3 mutation + IDH1 mutation (1)

FLT3 mutation + NRAS mutation + PTPN11 mutation (1)

FLT3 mutation + PTPN11 mutation (1)

FLT3 positive (1)

FLT3-ITD F692L + NPM1 mutation (1)

FLT3-ITD mutation + ASXL1 mutation (1)

FLT3-ITD mutation + ASXL1 mutation + NRAS mutation (1)

FLT3-ITD mutation + DNMT3A mutation + ASXL1 mutation (1)

FLT3-ITD mutation + DNMT3A mutation + NRAS mutation (1)

FLT3-ITD mutation + FLT3 D835Y + FLT3 F691L (1)

FLT3-ITD mutation + NRAS mutation + GATA2 mutation (1)

FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

FLT3‐ITD + DNMT3A mutation (1)

FLT3‐ITD + WT1 mutation (1)

MLL rearrangement + FLT3 mutation (1)

NPM1 mutation + FLT3-ITD mutation + TET2 mutation + CUX1 mutation (1)

NPM1 mutation + SRSF2 mutation + FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

IDH2 R140Q + NPM1 mutation (1)

IDH2 mutation + NPM1 mutation (1)

NPM1 exon 11 mutation (1)

NPM1 mutation + DNMT3A mutation + KMT2D mutation (1)

NPM1 mutation + NRAS mutation (1)

NPM1 mutation + SRSF2 mutation (1)

FLT3 F691L + FLT3 Y842H (0)

FLT3-ITD F692L (0)

PTPN11 mutation + NPM1 mutation (0)

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4years

NPM1 and FLT3-TKD mutations are enriched in patients with leukemia cutis. (PubMed, Dermatol Online J)

Our original hypothesis was that patients with LC would display a distinct mutation profile. Ultimately, the distribution of mutations observed in our cohort of LC patients largely reflects the mutational profile seen in AML patients in general.

4 years ago

Clinical • Journal

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FLT3 (Fms-related tyrosine kinase 3) • NPM1 (Nucleophosmin 1)

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NPM1 mutation • FLT3-TKD mutation • NPM1 mutation + FLT3-TKD mutation