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BIOMARKER:

DNMT3A mutation + FLT3-ITD mutation

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Other names: DNMT3A, DNA Methyltransferase 3 Alpha, DNA (Cytosine-5-)-Methyltransferase 3 Alpha, DNA (Cytosine-5)-Methyltransferase 3A, DNA MTase HsaIIIA, DNA Cytosine Methyltransferase 3A2, DNA Methyltransferase HsaIIIA, DNMT3A2, Dnmt3a, FLT3, Fms Related Tyrosine Kinase 3, Receptor-Type Tyrosine-Protein Kinase FLT3, Stem Cell Tyrosine Kinase 1, Fms-Like Tyrosine Kinase 3, CD135, FLK-2, STK1, Growth Factor Receptor Tyrosine Kinase Type III, Fetal Liver Kinase 2
Entrez ID:
DNMT3A mutation + FLT3-ITD mutation
AML
cytarabine
Resistant: C3 – Early Trials
DNMT3A mutation + FLT3-ITD mutation
AML
gilteritinib
Sensitive: C3 – Early Trials
DNMT3A mutation + FLT3-ITD mutation
AML
quizartinib
Sensitive: C3 – Early Trials
DNMT3A mutation + FLT3-ITD mutation
AML
venetoclax
Sensitive: C4 – Case Studies