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BIOMARKER:

NPM1 mutation

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Other names: Nucleophosmin (Nucleolar Phosphoprotein B23, Numatrin), Testicular Tissue Protein Li 128, Nucleolar Protein NO38, Numatrin, NPM1, Nucleophosmin 1, Nucleophosmin/Nucleoplasmin Family, Member 1, Nucleolar Phosphoprotein B23
Entrez ID:
Related biomarkers:
NPM1 mutation
AML
venetoclax
Sensitive: B - Late Trials
NPM1 mutation
AML
gemtuzumab ozogamicin
Sensitive: B - Late Trials
NPM1 mutation
AML
cytarabine
Sensitive: B - Late Trials
NPM1 mutation
AML
azacitidine
Sensitive: B - Late Trials
NPM1 mutation
AML
SNDX-5613
Sensitive: B - Late Trials
NPM1 mutation
AML
cytarabine + idarubicin hydrochloride
Sensitive: C2 – Inclusion Criteria
NPM1 mutation
AML
dactinomycin
Sensitive: C2 – Inclusion Criteria
NPM1 mutation
AML
GS-9973
Sensitive: C2 – Inclusion Criteria
NPM1 mutation
AML
sorafenib
Sensitive: C2 – Inclusion Criteria
NPM1 mutation
Leukemia
SNDX-5613
Sensitive: C2 – Inclusion Criteria
NPM1 mutation
AML
cytarabine / daunorubicin liposomal formulation
Sensitive: C3 – Early Trials
NPM1 mutation
AML
cytarabine
Sensitive: C3 – Early Trials
NPM1 mutation
AML
FLAI
Sensitive: C3 – Early Trials
NPM1 mutation
CMML
venetoclax
Sensitive: C3 – Early Trials
NPM1 mutation
MDS
decitabine
Sensitive: C3 – Early Trials
NPM1 mutation
AML
quizartinib
Sensitive: C3 – Early Trials
NPM1 mutation
AML
venetoclax + ruxolitinib
Sensitive: C3 – Early Trials
NPM1 mutation
MDS
azacitidine
Resistant: C3 – Early Trials
NPM1 mutation
AML
cytarabine + clofarabine
Sensitive: C3 – Early Trials
NPM1 mutation
AML
cytarabine + cladribine
Sensitive: C3 – Early Trials
NPM1 mutation
AML
decitabine + clofarabine
Sensitive: C3 – Early Trials
NPM1 mutation
AML
decitabine + cladribine
Sensitive: C3 – Early Trials
NPM1 mutation
AML
PD1 inhibitor
Sensitive: C3 – Early Trials
NPM1 mutation
AML
venetoclax + gilteritinib
Sensitive: C3 – Early Trials
NPM1 mutation
AML
ARO-002
Sensitive: C3 – Early Trials
NPM1 mutation
AML
ABBV-744
Sensitive: D – Preclinical
NPM1 mutation
AML
venetoclax + IACS-010759
Sensitive: D – Preclinical
NPM1 mutation
Leukemia
EPZ004777
Sensitive: D – Preclinical
NPM1 mutation
AML
NSC348884
Sensitive: D – Preclinical
NPM1 mutation
AML
DS-M1
Sensitive: D – Preclinical
NPM1 mutation
AML
abemaciclib + KO-539
Sensitive: D – Preclinical
NPM1 mutation
AML
KO-539 + OTX015
Sensitive: D – Preclinical
NPM1 mutation
AML
venetoclax + KO-539
Sensitive: D – Preclinical
NPM1 mutation
AML
NSC23766
Sensitive: D – Preclinical