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BIOMARKER:

FLT3 mutation + NPM1 mutation

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Other names: Nucleophosmin (Nucleolar Phosphoprotein B23, Numatrin), Testicular Tissue Protein Li 128, Nucleolar Protein NO38, Numatrin, NPM1, Nucleophosmin 1, Nucleophosmin/Nucleoplasmin Family, Member 1, Nucleolar Phosphoprotein B23, FLT3, Fms Related Tyrosine Kinase 3, Receptor-Type Tyrosine-Protein Kinase FLT3, Stem Cell Tyrosine Kinase 1, Fms-Like Tyrosine Kinase 3, CD135, FLK-2, STK1, Growth Factor Receptor Tyrosine Kinase Type III, Fetal Liver Kinase 2
Entrez ID:
FLT3 mutation + NPM1 mutation
AML
gilteritinib
Sensitive: C3 – Early Trials
FLT3 mutation + NPM1 mutation
AML
ivosidenib
Resistant: C3 – Early Trials
FLT3 mutation + NPM1 mutation
AML
TAK-659
Sensitive: D – Preclinical
FLT3 mutation + NPM1 mutation
AML
ixazomib
Resistant: D – Preclinical