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BIOMARKER:
FLT3-ITD mutation
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Other names: FLT3, Fms Related Tyrosine Kinase 3, Receptor-Type Tyrosine-Protein Kinase FLT3, Stem Cell Tyrosine Kinase 1, Fms-Like Tyrosine Kinase 3, CD135, FLK-2, STK1, Growth Factor Receptor Tyrosine Kinase Type III, Fetal Liver Kinase 2
Entrez ID:
FLT3-ITD mutation
AML
quizartinib
Sensitive
:
C2
Haematologica - 3wk
FLT3-ITD mutation
AML
midostaurin
Sensitive
:
A2
FLT3-ITD mutation
AML
gilteritinib
Sensitive
:
A2
FLT3-ITD mutation
AML
sorafenib
Sensitive
:
A2
FLT3-ITD mutation
AML
cytarabine
Resistant
:
B
FLT3-ITD mutation
AML
bortezomib
Sensitive
:
C2
FLT3-ITD mutation
AML
TP-0903
Sensitive
:
C2
FLT3-ITD mutation
AML
PHI-101
Sensitive
:
C2
FLT3-ITD mutation
AML
pexidartinib
Sensitive
:
C2
FLT3-ITD mutation
AML
gilteritinib + quizartinib + fingolimod
Sensitive
:
C3
FLT3-ITD mutation
AML
FLT3 inhibitor
Sensitive
:
C3
FLT3-ITD mutation
AML
cytarabine + idarubicin
Resistant
:
C3
FLT3-ITD mutation
AML
venetoclax
Sensitive
:
C3
FLT3-ITD mutation
AML
ponatinib
Sensitive
:
C3
FLT3-ITD mutation
AML
venetoclax + gilteritinib
Sensitive
:
C3
FLT3-ITD mutation
AML
gemtuzumab ozogamicin
Sensitive
:
C3
FLT3-ITD mutation
AML
selumetinib
Resistant
:
C3
FLT3-ITD mutation
AML
venetoclax + ruxolitinib
Sensitive
:
C3
FLT3-ITD mutation
AML
DA
Sensitive
:
C4
FLT3-ITD mutation
AML
bortezomib + verteporfin
Sensitive
:
D
FLT3-ITD mutation
AML
Max-40279
Sensitive
:
D
FLT3-ITD mutation
AML
FLT3 inhibitor + LIMK2 inhibitor
Sensitive
:
D
FLT3-ITD mutation
AML
ABBV-744
Sensitive
:
D
FLT3-ITD mutation
Leukemia
NSC305787
Sensitive
:
D
FLT3-ITD mutation
AML
venetoclax + SM09419
Sensitive
:
D
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