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BIOMARKER:

NPM1 mutation + DNMT3A mutation

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Other names: Nucleophosmin (Nucleolar Phosphoprotein B23, Numatrin), Testicular Tissue Protein Li 128, Nucleolar Protein NO38, Numatrin, NPM1, Nucleophosmin 1, Nucleophosmin/Nucleoplasmin Family, Member 1, Nucleolar Phosphoprotein B23, DNMT3A, DNA Methyltransferase 3 Alpha, DNA (Cytosine-5-)-Methyltransferase 3 Alpha, DNA (Cytosine-5)-Methyltransferase 3A, DNA MTase HsaIIIA, DNA Cytosine Methyltransferase 3A2, DNA Methyltransferase HsaIIIA, DNMT3A2, Dnmt3a
Entrez ID:
NPM1 mutation + DNMT3A mutation
AML
quizartinib
Sensitive: C3 – Early Trials
NPM1 mutation + DNMT3A mutation
AML
venetoclax + gilteritinib
Sensitive: C3 – Early Trials