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GENE:

MSH2 (MutS Homolog 2)

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MSH2 mutation	Gastric Cancer	MSH2 mutation	Gastric Cancer	tremelimumab Sensitive: C2 – Inclusion Criteria tremelimumab Sensitive : C2	tremelimumab Sensitive: C2 – Inclusion Criteria tremelimumab Sensitive : C2
MSH2 mutation	Gastric Cancer	MSH2 mutation	Gastric Cancer	durvalumab Sensitive: C2 – Inclusion Criteria durvalumab Sensitive : C2	durvalumab Sensitive: C2 – Inclusion Criteria durvalumab Sensitive : C2
MSH2 mutation	Pancreatic Ductal Adenocarcinoma	MSH2 mutation	Pancreatic Ductal Adenocarcinoma	Sensitive: C3 – Early Trials Sensitive : C3	Sensitive: C3 – Early Trials Sensitive : C3
MSH2 mutation	Colorectal Cancer	MSH2 mutation	Colorectal Cancer	5-fluorouracil + oxaliplatin Resistant: C3 – Early Trials 5-fluorouracil + oxaliplatin Resistant : C3	5-fluorouracil + oxaliplatin Resistant: C3 – Early Trials 5-fluorouracil + oxaliplatin Resistant : C3
MSH2 deletion	Endometrial Adenocarcinoma	MSH2 deletion	Endometrial Adenocarcinoma	nivolumab Sensitive: C3 – Early Trials nivolumab Sensitive : C3	nivolumab Sensitive: C3 – Early Trials nivolumab Sensitive : C3
MSH2 deletion	Prostate Cancer	MSH2 deletion	Prostate Cancer	nivolumab Sensitive: C3 – Early Trials nivolumab Sensitive : C3	nivolumab Sensitive: C3 – Early Trials nivolumab Sensitive : C3
MSH2 deletion + MSH6 deletion	Endometrial Cancer	MSH2 deletion + MSH6 deletion	Endometrial Cancer	dostarlimab-gxly Sensitive: C3 – Early Trials dostarlimab-gxly Sensitive : C3	dostarlimab-gxly Sensitive: C3 – Early Trials dostarlimab-gxly Sensitive : C3
MSH2 mutation	Urothelial Cancer	MSH2 mutation	Urothelial Cancer	nivolumab + ipilimumab Sensitive: C3 – Early Trials nivolumab + ipilimumab Sensitive : C3	nivolumab + ipilimumab Sensitive: C3 – Early Trials nivolumab + ipilimumab Sensitive : C3
MSH2 deletion + MSH6 deletion	Rectal Cancer	MSH2 deletion + MSH6 deletion	Rectal Cancer	nivolumab + ipilimumab Sensitive: C3 – Early Trials nivolumab + ipilimumab Sensitive : C3	nivolumab + ipilimumab Sensitive: C3 – Early Trials nivolumab + ipilimumab Sensitive : C3
MSH2 mutation	Rectal Cancer	MSH2 mutation	Rectal Cancer	nivolumab + ipilimumab Sensitive: C3 – Early Trials nivolumab + ipilimumab Sensitive : C3	nivolumab + ipilimumab Sensitive: C3 – Early Trials nivolumab + ipilimumab Sensitive : C3
MSH2 mutation	Adrenal Cortex Carcinoma	MSH2 mutation	Adrenal Cortex Carcinoma	pembrolizumab Sensitive: C4 – Case Studies pembrolizumab Sensitive : C4	pembrolizumab Sensitive: C4 – Case Studies pembrolizumab Sensitive : C4
MSH2 mutation + MSH6 mutation	Pituitary Gland Carcinoma	MSH2 mutation + MSH6 mutation	Pituitary Gland Carcinoma	pembrolizumab Sensitive: C4 – Case Studies pembrolizumab Sensitive : C4	pembrolizumab Sensitive: C4 – Case Studies pembrolizumab Sensitive : C4
MSH2 deletion + MSH6 deletion	Pituitary Gland Carcinoma	MSH2 deletion + MSH6 deletion	Pituitary Gland Carcinoma	temozolomide Resistant: C4 – Case Studies temozolomide Resistant : C4	temozolomide Resistant: C4 – Case Studies temozolomide Resistant : C4
MSI-H + MSH2 expression + MSH6 expression	Prostate Cancer	MSI-H + MSH2 expression + MSH6 expression	Prostate Cancer	docetaxel Sensitive: C4 – Case Studies docetaxel Sensitive : C4	docetaxel Sensitive: C4 – Case Studies docetaxel Sensitive : C4
MSH2 deletion	Urothelial Cancer	MSH2 deletion	Urothelial Cancer	durvalumab + MEDI0680 Sensitive: C4 – Case Studies durvalumab + MEDI0680 Sensitive : C4	durvalumab + MEDI0680 Sensitive: C4 – Case Studies durvalumab + MEDI0680 Sensitive : C4
MSH2 negative + MSH6 negative	Prostate Cancer	MSH2 negative + MSH6 negative	Prostate Cancer	pembrolizumab Sensitive: C4 – Case Studies pembrolizumab Sensitive : C4	pembrolizumab Sensitive: C4 – Case Studies pembrolizumab Sensitive : C4
MSH2 mutation + MSH6 mutation	Prostate Cancer	MSH2 mutation + MSH6 mutation	Prostate Cancer	nivolumab + ipilimumab Sensitive: C4 – Case Studies nivolumab + ipilimumab Sensitive : C4	nivolumab + ipilimumab Sensitive: C4 – Case Studies nivolumab + ipilimumab Sensitive : C4
MSH2 mutation + MSH6 mutation + BRCA1 mutation	Prostate Cancer	MSH2 mutation + MSH6 mutation + BRCA1 mutation	Prostate Cancer	nivolumab + ipilimumab Sensitive: C4 – Case Studies nivolumab + ipilimumab Sensitive : C4	nivolumab + ipilimumab Sensitive: C4 – Case Studies nivolumab + ipilimumab Sensitive : C4
MSH2 489_494deTGGGTA	Colon Cancer	MSH2 489_494deTGGGTA	Colon Cancer	pembrolizumab Sensitive: C4 – Case Studies pembrolizumab Sensitive : C4	pembrolizumab Sensitive: C4 – Case Studies pembrolizumab Sensitive : C4
MSH2 deletion	Glioblastoma	MSH2 deletion	Glioblastoma	temozolomide Resistant: D – Preclinical temozolomide Resistant : D	temozolomide Resistant: D – Preclinical temozolomide Resistant : D