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our Premium Content: News alerts, weekly reports and conference plannersTEST:BROCA Cancer Risk Panel
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News alerts, weekly reports and conference planners
Company:
University of WashingtonType:
Laboratory Developed Test
Related tests:
BROCA is useful for the evaluation of patients with a suspected hereditary cancer predisposition, with a focus on syndromes that include breast or ovarian cancer as one of the cancer types. Depending on the causative gene involved, these cancers may co-occur with other cancer types (such as colorectal, endometrial, pancreatic, endocrine, or melanoma). BROCA uses next-generation sequencing to detect most mutations. The assay completely sequences all exons of these genes AND detects large deletions and duplications.
Cancer:
Breast Cancer, Colorectal Cancer, Endocrine Cancer, Endometrial Cancer, Melanoma, Ovarian Cancer, Pancreatic Cancer
Gene:
AKT1 (V-akt murine thymoma viral oncogene homolog 1), ALK (Anaplastic lymphoma kinase), APC (APC Regulator Of WNT Signaling Pathway), ATM (ATM serine/threonine kinase), ATR (Ataxia telangiectasia and Rad3-related protein), BAP1 (BRCA1 Associated Protein 1)
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AKT1 (V-akt murine thymoma viral oncogene homolog 1), ALK (Anaplastic lymphoma kinase), APC (APC Regulator Of WNT Signaling Pathway), ATM (ATM serine/threonine kinase), ATR (Ataxia telangiectasia and Rad3-related protein), BAP1 (BRCA1 Associated Protein 1), BARD1 (BRCA1 Associated RING Domain 1), BRCA1 (Breast cancer 1, early onset), BRCA2 (Breast cancer 2, early onset), BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1), CDH1 (Cadherin 1), CDK12 (Cyclin dependent kinase 12), CDK4 (Cyclin-dependent kinase 4), CDKN2A (Cyclin Dependent Kinase Inhibitor 2A), CHEK1 (Checkpoint kinase 1), CHEK2 (Checkpoint kinase 2), CTNNA1 (Catenin Alpha 1), DICER1 (Dicer 1 Ribonuclease III), GEN1 (GEN1 Holliday junction 5' flap endonuclease), HOXB13 (Homeobox B13), MET (MET proto-oncogene, receptor tyrosine kinase), MLH1 (MutL homolog 1), MLH3 (MutL homolog 3), MSH2 (MutS Homolog 2), MSH3 (MutS Homolog 3), MSH6 (MutS homolog 6), MUTYH (MutY homolog), NF1 (Neurofibromin 1), PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha), POLD1 (DNA Polymerase Delta 1), POLE (DNA Polymerase Epsilon), PTCH1 (Patched 1), PTEN (Phosphatase and tensin homolog), RAD51B (RAD51 Paralog B), RAD51C (RAD51 paralog C), RAD51D (RAD51 paralog D), RB1 (RB Transcriptional Corepressor 1), RET (Ret Proto-Oncogene), SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B), SDHC (Succinate Dehydrogenase Complex Subunit C), SMAD4 (SMAD family member 4), SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4), TP53 (Tumor protein P53), VHL (von Hippel-Lindau tumor suppressor)
Method:
Next-Generation Sequencing (NGS)
