›
^
Contact us to learn more about
our Premium Content: News alerts, weekly reports and conference plannersTEST:NovoFocus™ PARPi CDx
Contact us to learn more about our Premium Content:
News alerts, weekly reports and conference planners
Company:
NovogeneType:
Laboratory Developed Test
Related tests:
NovoFocus™ PARPi CDx 1.0 is a next-generation sequencing (NGS)-based companion diagnostic (CDx) assay for poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) therapy in ovarian and breast cancers, NovoFocus™ PARPi CDx 1.0 interrogates 45 genes. It can detect genomic abnormalities (SNV, InDel, CNV and Fusion) and homologous recombination deficiency (HRD). Besides, it provides targeted therapy options and related hereditary cancer risk assessment.
Cancer:
Colon Cancer, HER2 Negative Breast Cancer, Ovarian Cancer, Triple Negative Breast Cancer
Gene:
APC (APC Regulator Of WNT Signaling Pathway), AR (Androgen receptor), ATM (ATM serine/threonine kinase), ATR (Ataxia telangiectasia and Rad3-related protein), BARD1 (BRCA1 Associated RING Domain 1), BRCA1 (Breast cancer 1, early onset)
See More ...
APC (APC Regulator Of WNT Signaling Pathway), AR (Androgen receptor), ATM (ATM serine/threonine kinase), ATR (Ataxia telangiectasia and Rad3-related protein), BARD1 (BRCA1 Associated RING Domain 1), BRCA1 (Breast cancer 1, early onset), BRCA2 (Breast cancer 2, early onset), BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1), CDH1 (Cadherin 1), CDK12 (Cyclin dependent kinase 12), CHEK1 (Checkpoint kinase 1), CHEK2 (Checkpoint kinase 2), EPCAM (Epithelial cell adhesion molecule), ERCC3 (ERCC Excision Repair 3, TFIIH Core Complex Helicase Subunit), FANCA (FA Complementation Group A), FANCL (FA Complementation Group L), FANCM (FA Complementation Group M), HDAC2 (Histone deacetylase 2), HER-2 (Human epidermal growth factor receptor 2), MLH1 (MutL homolog 1), MLH3 (MutL homolog 3), MRE11A (MRE11 homolog, double strand break repair nuclease), MSH2 (MutS Homolog 2), MSH6 (MutS homolog 6), NF1 (Neurofibromin 1), PALB2 (Partner and localizer of BRCA2), PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha), PMS2 (PMS1 protein homolog 2), PPM1D (Protein Phosphatase Mg2+/Mn2+ Dependent 1D), PPP2R2A (Protein Phosphatase 2, Regulatory Subunit B, Alpha), PTEN (Phosphatase and tensin homolog), RAD50 (RAD50 Double Strand Break Repair Protein), RAD51B (RAD51 Paralog B), RAD51C (RAD51 paralog C), RAD51D (RAD51 paralog D), RAD54L (DNA Repair And Recombination Protein RAD54), STK11 (Serine/threonine kinase 11), TP53 (Tumor protein P53), TSC1 (TSC complex subunit 1), TSC2 (TSC complex subunit 2)
Method:
Next-Generation Sequencing (NGS)
