TumorNext-Lynch tests for both germline (inherited) mutations that cause Lynch syndrome, as well as mutations and other changes in tumor that may be able to rule out Lynch syndrome. Testing should be considered by Patients with a personal history of colorectal or uterine cancer who: Have tumor screening results that suggest a possible diagnosis of Lynch syndrome, like abnormal MSI or IHC results and Have a personal and family history of cancer suspicious for Lynch syndrome.
Bladder Cancer, Colorectal Cancer, Endometrial Cancer, Ovarian Cancer, Pancreatic Cancer
BRAF (B-raf proto-oncogene), EPCAM (Epithelial cell adhesion molecule), KRAS (KRAS proto-oncogene GTPase), MLH1 (MutL homolog 1), MSH2 (MutS Homolog 2), MSH6 (MutS homolog 6)
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Next-Generation Sequencing (NGS)