›
^
Contact us to learn more about
our Premium Content: News alerts, weekly reports and conference plannersTEST:OvaNext®
Contact us to learn more about our Premium Content:
News alerts, weekly reports and conference planners
Company:
Konica MinoltaType:
Laboratory Developed Test
Related tests:
OvaNext analyzes 25 genes. 24 genes (excluding EPCAM) are evaluated by next generation sequencing (NGS) or Sanger sequencing of all coding domains, and well into the flanking 5’ and 3’ ends of all the introns and untranslated regions. In addition, sequencing of the promoter region is performed for the following genes: PTEN (c.-1300 to c.-745), MLH1 (c.-337 to c.-194), and MSH2 (c.-318 to c.-65). The inversion of coding exons 1-7 of the MSH2 gene and the BRCA2 Portuguese founder mutation, c.156_157insAlu (also known as 384insAlu) are detected by NGS and confirmed by PCR and agarose gel electrophoresis.
Cancer:
Breast Cancer, Ovarian Cancer, Uterine Cancer
Gene:
ATM (ATM serine/threonine kinase), BARD1 (BRCA1 Associated RING Domain 1), BRCA1 (Breast cancer 1, early onset), BRCA2 (Breast cancer 2, early onset), CDH1 (Cadherin 1), CHEK2 (Checkpoint kinase 2)
See More ...
ATM (ATM serine/threonine kinase), BARD1 (BRCA1 Associated RING Domain 1), BRCA1 (Breast cancer 1, early onset), BRCA2 (Breast cancer 2, early onset), CDH1 (Cadherin 1), CHEK2 (Checkpoint kinase 2), EPCAM (Epithelial cell adhesion molecule), MLH1 (MutL homolog 1), MRE11A (MRE11 homolog, double strand break repair nuclease), MSH2 (MutS Homolog 2), MSH6 (MutS homolog 6), NBN (Nibrin Nijmegen Breakage Syndrome 1 (Nibrin)), NF1 (Neurofibromin 1), PALB2 (Partner and localizer of BRCA2), PMS2 (PMS1 protein homolog 2), PTEN (Phosphatase and tensin homolog), RAD50 (RAD50 Double Strand Break Repair Protein), RAD51C (RAD51 paralog C), RAD51D (RAD51 paralog D), SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4), STK11 (Serine/threonine kinase 11), TP53 (Tumor protein P53)
Method:
Next-Generation Sequencing (NGS)
