Associations - POLE (DNA Polymerase Epsilon)

POLE mutation	Solid Tumor	POLE mutation	Solid Tumor	Immunotherapy Sensitive: B - Late Trials Immunotherapy Sensitive : B	Immunotherapy Sensitive: B - Late Trials Immunotherapy Sensitive : B
POLE mutation	Endometrial Cancer	POLE mutation	Endometrial Cancer	pembrolizumab Sensitive: C2 – Inclusion Criteria pembrolizumab Sensitive : C2	pembrolizumab Sensitive: C2 – Inclusion Criteria pembrolizumab Sensitive : C2
POLE mutation	Gastric Cancer	POLE mutation	Gastric Cancer	tremelimumab Sensitive: C2 – Inclusion Criteria tremelimumab Sensitive : C2	tremelimumab Sensitive: C2 – Inclusion Criteria tremelimumab Sensitive : C2
POLE mutation	Gastric Cancer	POLE mutation	Gastric Cancer	durvalumab Sensitive: C2 – Inclusion Criteria durvalumab Sensitive : C2	durvalumab Sensitive: C2 – Inclusion Criteria durvalumab Sensitive : C2
POLE mutation	Solid Tumor	POLE mutation	Solid Tumor	avelumab Sensitive: C2 – Inclusion Criteria avelumab Sensitive : C2	avelumab Sensitive: C2 – Inclusion Criteria avelumab Sensitive : C2
POLE mutation	Endometrial Cancer	POLE mutation	Endometrial Cancer	avelumab Sensitive: C2 – Inclusion Criteria avelumab Sensitive : C2	avelumab Sensitive: C2 – Inclusion Criteria avelumab Sensitive : C2
POLE mutation	Solid Tumor	POLE mutation	Solid Tumor	toripalimab-tpzi Sensitive: C2 – Inclusion Criteria toripalimab-tpzi Sensitive : C2	toripalimab-tpzi Sensitive: C2 – Inclusion Criteria toripalimab-tpzi Sensitive : C2
POLE mutation	Solid Tumor	POLE mutation	Solid Tumor	dostarlimab-gxly Sensitive: C2 – Inclusion Criteria dostarlimab-gxly Sensitive : C2	dostarlimab-gxly Sensitive: C2 – Inclusion Criteria dostarlimab-gxly Sensitive : C2
POLE mutation	Colorectal Cancer	POLE mutation	Colorectal Cancer	durvalumab Sensitive: C2 – Inclusion Criteria durvalumab Sensitive : C2	durvalumab Sensitive: C2 – Inclusion Criteria durvalumab Sensitive : C2
POLE mutation	Melanoma	POLE mutation	Melanoma	PD1 inhibitor + PD-L1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor + PD-L1 inhibitor Sensitive : C3	PD1 inhibitor + PD-L1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor + PD-L1 inhibitor Sensitive : C3
POLE mutation	Cholangiocarcinoma	POLE mutation	Cholangiocarcinoma	PD1 inhibitor + PD-L1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor + PD-L1 inhibitor Sensitive : C3	PD1 inhibitor + PD-L1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor + PD-L1 inhibitor Sensitive : C3
POLE mutation	Non Small Cell Lung Cancer	POLE mutation	Non Small Cell Lung Cancer	PD1 inhibitor + PD-L1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor + PD-L1 inhibitor Sensitive : C3	PD1 inhibitor + PD-L1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor + PD-L1 inhibitor Sensitive : C3
POLE mutation	Colorectal Cancer	POLE mutation	Colorectal Cancer	PD1 inhibitor + PD-L1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor + PD-L1 inhibitor Sensitive : C3	PD1 inhibitor + PD-L1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor + PD-L1 inhibitor Sensitive : C3
POLE mutation	Melanoma	POLE mutation	Melanoma	PD-L1 inhibitor Sensitive: C3 – Early Trials PD-L1 inhibitor Sensitive : C3	PD-L1 inhibitor Sensitive: C3 – Early Trials PD-L1 inhibitor Sensitive : C3
POLE mutation	Cholangiocarcinoma	POLE mutation	Cholangiocarcinoma	PD-L1 inhibitor Sensitive: C3 – Early Trials PD-L1 inhibitor Sensitive : C3	PD-L1 inhibitor Sensitive: C3 – Early Trials PD-L1 inhibitor Sensitive : C3
POLE mutation	Non Small Cell Lung Cancer	POLE mutation	Non Small Cell Lung Cancer	PD-L1 inhibitor Sensitive: C3 – Early Trials PD-L1 inhibitor Sensitive : C3	PD-L1 inhibitor Sensitive: C3 – Early Trials PD-L1 inhibitor Sensitive : C3
POLE mutation	Colorectal Cancer	POLE mutation	Colorectal Cancer	PD-L1 inhibitor Sensitive: C3 – Early Trials PD-L1 inhibitor Sensitive : C3	PD-L1 inhibitor Sensitive: C3 – Early Trials PD-L1 inhibitor Sensitive : C3
POLE mutation	Melanoma	POLE mutation	Melanoma	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3
POLE mutation	Cholangiocarcinoma	POLE mutation	Cholangiocarcinoma	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3
POLE mutation	Non Small Cell Lung Cancer	POLE mutation	Non Small Cell Lung Cancer	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3
POLE mutation	Colorectal Cancer	POLE mutation	Colorectal Cancer	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3	PD1 inhibitor Sensitive: C3 – Early Trials PD1 inhibitor Sensitive : C3
POLE V411L	Endometrial Cancer	POLE V411L	Endometrial Cancer	nivolumab Sensitive: C3 – Early Trials nivolumab Sensitive : C3	nivolumab Sensitive: C3 – Early Trials nivolumab Sensitive : C3
POLE V411L	Colorectal Cancer	POLE V411L	Colorectal Cancer	nivolumab Sensitive: C3 – Early Trials nivolumab Sensitive : C3	nivolumab Sensitive: C3 – Early Trials nivolumab Sensitive : C3
POLE P286R	Colorectal Cancer	POLE P286R	Colorectal Cancer	nivolumab Sensitive: C3 – Early Trials nivolumab Sensitive : C3	nivolumab Sensitive: C3 – Early Trials nivolumab Sensitive : C3
POLE P286R	Endometrial Cancer	POLE P286R	Endometrial Cancer	nivolumab Sensitive: C3 – Early Trials nivolumab Sensitive : C3	nivolumab Sensitive: C3 – Early Trials nivolumab Sensitive : C3
POLE mutation	Colorectal Cancer	POLE mutation	Colorectal Cancer	nivolumab + ipilimumab Sensitive: C3 – Early Trials nivolumab + ipilimumab Sensitive : C3	nivolumab + ipilimumab Sensitive: C3 – Early Trials nivolumab + ipilimumab Sensitive : C3
POLE mutation	Colorectal Cancer	POLE mutation	Colorectal Cancer	nivolumab Sensitive: C3 – Early Trials nivolumab Sensitive : C3	nivolumab Sensitive: C3 – Early Trials nivolumab Sensitive : C3
POLE A456P	Colon Cancer	POLE A456P	Colon Cancer	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3
POLE mutation	Gastroesophageal Cancer	POLE mutation	Gastroesophageal Cancer	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3
POLE mutation	Non Small Cell Lung Cancer	POLE mutation	Non Small Cell Lung Cancer	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3
POLE EDM	Colorectal Cancer	POLE EDM	Colorectal Cancer	durvalumab Sensitive: C3 – Early Trials durvalumab Sensitive : C3	durvalumab Sensitive: C3 – Early Trials durvalumab Sensitive : C3
MSI-H/dMMR + POLE mutation	Gastric Cancer	MSI-H/dMMR + POLE mutation	Gastric Cancer	dostarlimab-gxly Sensitive: C3 – Early Trials dostarlimab-gxly Sensitive : C3	dostarlimab-gxly Sensitive: C3 – Early Trials dostarlimab-gxly Sensitive : C3

POLE (DNA Polymerase Epsilon)

Associations(45)

Associations
(45)