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BIOMARKER:

BRAF V600E + PIK3CA mutation

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Entrez ID:

Related biomarkers:

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BRAF V600E (255)

BRAF mutation (129)

PIK3CA mutation (108)

BRAF V600 (106)

PIK3CA H1047R (45)

PIK3CA E545K (26)

BRAF V600K (25)

BRAF wild-type (25)

PIK3CA E542K (10)

RAS wild-type + BRAF wild-type (7)

BRAF V600E + RNF43 mutation (6)

EGFR mutation + BRAF V600E (6)

NRAS mutation + BRAF mutation (4)

EGFR mutation + PIK3CA mutation (4)

PIK3CA E545 (4)

PIK3CA H1047 (4)

PIK3CA K111N (4)

BRAF T1799A (3)

BRAF V600E + TERT mutation (3)

BRAF delNVTAP (3)

NRAS Q61K + BRAF V600E (3)

TERT mutation + BRAF V600E (3)

PIK3CA E542 (3)

PIK3CA E546 (3)

PIK3CA H1047L (3)

PIK3CA M1043I (3)

PIK3CA mutation + PTEN mutation (3)

PIK3CA wild-type (3)

BRAF V600E + MAP2K1 I111S (2)

BRAF mutation + MEK1 P124L (2)

BRAF mutation + NF1 mutation (2)

BRAF rearrangement (2)

EGFR mutation + BRAF V600 (2)

IDH1 wild-type + BRAF mutation (2)

KRAS G13D + BRAF mutation (2)

MYD88 L265P + BRAF V600E (2)

NRAS G12C + BRAF mutation (2)

EGFR T790M + PIK3CA H1047R (2)

ER negative + PIK3CA H1047R (2)

HER-2 V777L + PIK3CA H1047R (2)

PIK3CA C420R (2)

PIK3CA E545A (2)

PIK3CA N345K (2)

PIK3CA Q75E (2)

PIK3CA mutation + ESR1 mutation (2)

PIK3CA mutation + KRAS mutation (2)

TP53 T175H + PIK3CA H1047R (2)

TP53 mutation + PIK3CA mutation + CD74 mutation (2)

AKT1 E17K + BRAF V600 (1)

BRAF 486_490 del (1)

BRAF G466E + NF1 Y2285fs*5 + NF1 Y2640fs*3 + TP53 D281Y (1)

BRAF G466V + KIT K509Q (1)

BRAF N486-P490del + TP53 V157G (1)

BRAF V600 wild-type (1)

BRAF V600DK601del (1)

BRAF V600E + BRAF G469A + BRAF G469V (1)

BRAF V600E + BRAF K601_W604del (1)

BRAF V600E + BRAF L514V (1)

BRAF V600E + BRAF V600K (1)

BRAF V600E + KRAS G12R (1)

BRAF V600E + MSI-H/dMMR (1)

BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L (1)

BRAF V600_K601delinsE (1)

BRAF mutation + EGFR mutation (1)

BRAF mutation + MAP2K1 mutation (1)

BRAF mutation + RAS mutation (1)

BRAF mutation + TERT −124C>T (1)

BRAF mutation + TERT −138CC>TT (1)

BRAF mutation + TERT −139CC>TT (1)

BRAF mutation + TERT −146C>T (1)

BRAF mutation + TET2 mutation (1)

BRAF mutation + TP53 mutation (1)

BRAF wild-type + NRAS wild-type (1)

EGFR T790M + BRAF V600E (1)

EGFR exon 19 deletion + BRAF V600E (1)

EGFR mutation + BRAF G469A (1)

EGFR mutation + BRAF mutation + TP53 mutation (1)

KRAS G12A + BRAF D549N (1)

KRAS G12V + BRAF V600E (1)

MAP2K1 V211D + BRAF mutation (1)

NRAS G12C + BRAF V600E + BRAF V600D (1)

NRAS G13D + BRAF V600E (1)

RAS wild-type + BRAF wild-type + MAP2K1 N57K (1)

ROS1 rearrangement + BRAF V600E (1)

TERT promoter mutation + BRAF V600 (1)

ALK rearrangement + PIK3CA mutation (1)

ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)

EGFR L858R + PIK3CA H1047R + PIK3CA E545K (1)

EGFR T790M + PIK3CA Mutation (1)

EGFR exon 19 mutation + EGFR C797S + PIK3CA mutation (1)

HR positive + PIK3CA H1047R (1)

HR positive + PIK3CA H1047R + ER D538G (1)

HR positive + PIK3CA H1047R + PIK3CA D350G + ER D538G (1)

IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)

PIK3CA D350G (1)

PIK3CA E110K (1)

PIK3CA E453K (1)

PIK3CA E542Q (1)

PIK3CA E545G (1)

PIK3CA E545X (1)

PIK3CA G1049R (1)

PIK3CA G1049R + AKT1 E17K (1)

PIK3CA G106_108del (1)

PIK3CA H1047R + PIK3CA D959N + ER E380Q (1)

PIK3CA H1047X (1)

PIK3CA I391M (1)

PIK3CA K944N (1)

PIK3CA K966E (1)

PIK3CA N345K + PIK3CA N1044K (1)

PIK3CA P449T (1)

PIK3CA Q546 (1)

PIK3CA Q546K (1)

PIK3CA R38C (1)

PIK3CA V955G (1)

PIK3CA mutation + AKT1 mutation + PTEN mutation (1)

PIK3CA mutation + EP300 mutation (1)

PIK3CA mutation + ER mutation (1)

PIK3CA mutation + FGFR2 rearrangement (1)

PIK3CA mutation + HRAS mutation (1)

PIK3CA mutation + PTEN mutation + KRAS mutation (1)

PIK3CA mutation + TERT promoter mutation (1)

PIK3CA mutation + TTN mutation + IDH2 mutation (1)

PIK3CA wild-type + KRAS wild-type (1)

PIK3CA wild-type + PTEN wild-type (1)

PIK3CA Q546R (1)

BRAF V600E + TERT mutation (0)

BRAF V600E + KRAS G12D (0)

BRAF V600E + MAP2K1 P124S (0)

BRAF exon 11 mutation (0)

BRAF exon 15 mutation (0)

CDKN2A mutation + BRAF V600E (0)

IDH mutation + BRAF V600E (0)

IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)

HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)

HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)

HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)

HER-2 negative + HR positive + PIK3CA mutation (0)

PIK3CA G542L (0)

BRAF V600E (255)

BRAF mutation (129)

PIK3CA mutation (108)

BRAF V600 (106)

PIK3CA H1047R (45)

PIK3CA E545K (26)

BRAF V600K (25)

BRAF wild-type (25)

PIK3CA E542K (10)

RAS wild-type + BRAF wild-type (7)

BRAF V600E + RNF43 mutation (6)

EGFR mutation + BRAF V600E (6)

NRAS mutation + BRAF mutation (4)

EGFR mutation + PIK3CA mutation (4)

PIK3CA E545 (4)

PIK3CA H1047 (4)

PIK3CA K111N (4)

BRAF T1799A (3)

BRAF V600E + TERT mutation (3)

BRAF delNVTAP (3)

NRAS Q61K + BRAF V600E (3)

TERT mutation + BRAF V600E (3)

PIK3CA E542 (3)

PIK3CA E546 (3)

PIK3CA H1047L (3)

PIK3CA M1043I (3)

PIK3CA mutation + PTEN mutation (3)

PIK3CA wild-type (3)

BRAF V600E + MAP2K1 I111S (2)

BRAF mutation + MEK1 P124L (2)

BRAF mutation + NF1 mutation (2)

BRAF rearrangement (2)

EGFR mutation + BRAF V600 (2)

IDH1 wild-type + BRAF mutation (2)

KRAS G13D + BRAF mutation (2)

MYD88 L265P + BRAF V600E (2)

NRAS G12C + BRAF mutation (2)

EGFR T790M + PIK3CA H1047R (2)

ER negative + PIK3CA H1047R (2)

HER-2 V777L + PIK3CA H1047R (2)

PIK3CA C420R (2)

PIK3CA E545A (2)

PIK3CA N345K (2)

PIK3CA Q75E (2)

PIK3CA mutation + ESR1 mutation (2)

PIK3CA mutation + KRAS mutation (2)

TP53 T175H + PIK3CA H1047R (2)

TP53 mutation + PIK3CA mutation + CD74 mutation (2)

AKT1 E17K + BRAF V600 (1)

BRAF 486_490 del (1)

BRAF G466E + NF1 Y2285fs*5 + NF1 Y2640fs*3 + TP53 D281Y (1)

BRAF G466V + KIT K509Q (1)

BRAF N486-P490del + TP53 V157G (1)

BRAF V600 wild-type (1)

BRAF V600DK601del (1)

BRAF V600E + BRAF G469A + BRAF G469V (1)

BRAF V600E + BRAF K601_W604del (1)

BRAF V600E + BRAF L514V (1)

BRAF V600E + BRAF V600K (1)

BRAF V600E + KRAS G12R (1)

BRAF V600E + MSI-H/dMMR (1)

BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L (1)

BRAF V600_K601delinsE (1)

BRAF mutation + EGFR mutation (1)

BRAF mutation + MAP2K1 mutation (1)

BRAF mutation + RAS mutation (1)

BRAF mutation + TERT −124C>T (1)

BRAF mutation + TERT −138CC>TT (1)

BRAF mutation + TERT −139CC>TT (1)

BRAF mutation + TERT −146C>T (1)

BRAF mutation + TET2 mutation (1)

BRAF mutation + TP53 mutation (1)

BRAF wild-type + NRAS wild-type (1)

EGFR T790M + BRAF V600E (1)

EGFR exon 19 deletion + BRAF V600E (1)

EGFR mutation + BRAF G469A (1)

EGFR mutation + BRAF mutation + TP53 mutation (1)

KRAS G12A + BRAF D549N (1)

KRAS G12V + BRAF V600E (1)

MAP2K1 V211D + BRAF mutation (1)

NRAS G12C + BRAF V600E + BRAF V600D (1)

NRAS G13D + BRAF V600E (1)

RAS wild-type + BRAF wild-type + MAP2K1 N57K (1)

ROS1 rearrangement + BRAF V600E (1)

TERT promoter mutation + BRAF V600 (1)

ALK rearrangement + PIK3CA mutation (1)

ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)

EGFR L858R + PIK3CA H1047R + PIK3CA E545K (1)

EGFR T790M + PIK3CA Mutation (1)

EGFR exon 19 mutation + EGFR C797S + PIK3CA mutation (1)

HR positive + PIK3CA H1047R (1)

HR positive + PIK3CA H1047R + ER D538G (1)

HR positive + PIK3CA H1047R + PIK3CA D350G + ER D538G (1)

IDH1 R132C + PIK3CA E545K + IDH2 R172K (1)

PIK3CA D350G (1)

PIK3CA E110K (1)

PIK3CA E453K (1)

PIK3CA E542Q (1)

PIK3CA E545G (1)

PIK3CA E545X (1)

PIK3CA G1049R (1)

PIK3CA G1049R + AKT1 E17K (1)

PIK3CA G106_108del (1)

PIK3CA H1047R + PIK3CA D959N + ER E380Q (1)

PIK3CA H1047X (1)

PIK3CA I391M (1)

PIK3CA K944N (1)

PIK3CA K966E (1)

PIK3CA N345K + PIK3CA N1044K (1)

PIK3CA P449T (1)

PIK3CA Q546 (1)

PIK3CA Q546K (1)

PIK3CA R38C (1)

PIK3CA V955G (1)

PIK3CA mutation + AKT1 mutation + PTEN mutation (1)

PIK3CA mutation + EP300 mutation (1)

PIK3CA mutation + ER mutation (1)

PIK3CA mutation + FGFR2 rearrangement (1)

PIK3CA mutation + HRAS mutation (1)

PIK3CA mutation + PTEN mutation + KRAS mutation (1)

PIK3CA mutation + TERT promoter mutation (1)

PIK3CA mutation + TTN mutation + IDH2 mutation (1)

PIK3CA wild-type + KRAS wild-type (1)

PIK3CA wild-type + PTEN wild-type (1)

PIK3CA Q546R (1)

BRAF V600E + TERT mutation (0)

BRAF V600E + KRAS G12D (0)

BRAF V600E + MAP2K1 P124S (0)

BRAF exon 11 mutation (0)

BRAF exon 15 mutation (0)

CDKN2A mutation + BRAF V600E (0)

IDH mutation + BRAF V600E (0)

IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)

HER-2 negative + HR positive + PIK3CA exon 20 mutation (0)

HER-2 negative + HR positive + PIK3CA exon 7 mutation (0)

HER-2 negative + HR positive + PIK3CA exon 9 mutation (0)

HER-2 negative + HR positive + PIK3CA mutation (0)

PIK3CA G542L (0)

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BRAF V600E + PIK3CA mutation	Colorectal Cancer	BRAF V600E + PIK3CA mutation	Colorectal Cancer	cetuximab + alpelisib + encorafenib Resistant: C3 – Early Trials cetuximab + alpelisib + encorafenib Resistant : C3	cetuximab + alpelisib + encorafenib Resistant: C3 – Early Trials cetuximab + alpelisib + encorafenib Resistant : C3
BRAF V600E + PIK3CA mutation	Colorectal Cancer	BRAF V600E + PIK3CA mutation	Colorectal Cancer	cetuximab + binimetinib + encorafenib Resistant: C3 – Early Trials cetuximab + binimetinib + encorafenib Resistant : C3	cetuximab + binimetinib + encorafenib Resistant: C3 – Early Trials cetuximab + binimetinib + encorafenib Resistant : C3
BRAF V600E + PIK3CA mutation	Colorectal Cancer	BRAF V600E + PIK3CA mutation	Colorectal Cancer	cetuximab + encorafenib Resistant: C3 – Early Trials cetuximab + encorafenib Resistant : C3	cetuximab + encorafenib Resistant: C3 – Early Trials cetuximab + encorafenib Resistant : C3
BRAF V600E + PIK3CA mutation	Astrocytoma	BRAF V600E + PIK3CA mutation	Astrocytoma	vemurafenib + everolimus Sensitive: C4 – Case Studies vemurafenib + everolimus Sensitive : C4	vemurafenib + everolimus Sensitive: C4 – Case Studies vemurafenib + everolimus Sensitive : C4