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    BIOMARKER:

    PIK3CA E545K

    i
    Other names: PIK3CA, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, Phosphoinositide-3-kinase, catalytic, alpha polypeptide, Serine/threonine protein kinase PIK3CA, PtdIns-3-kinase subunit P110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 KDa catalytic subunit alpha, Phosphatidylinositol 3-kinase, Catalytic, 110-KD, alpha, PI3-kinase P110 subunit alpha, PI3-kinase subunit alpha, PtdIns-3-kinase subunit alpha, PI3Kalpha, P110alpha, PI3K
    Entrez ID:
    5290
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    PIK3CA E545K
    Colorectal Cancer
    cetuximab
    Resistant
    :
    C3
    PIK3CA E545K
    Non Small Cell Lung Cancer
    osimertinib
    Resistant
    :
    C3
    PIK3CA E545K
    Ovarian Cancer
    TAS-117
    Sensitive
    :
    C3
    PIK3CA E545K
    Breast Cancer
    olaparib + durvalumab + AZD5363
    Sensitive
    :
    C3
    PIK3CA E545K
    Gastric Cancer
    CYH33
    Sensitive
    :
    C4
    PIK3CA E545K
    Breast Cancer
    CYH33
    Sensitive
    :
    C4
    PIK3CA E545K
    Ovarian Cancer
    CYH33
    Sensitive
    :
    C4
    PIK3CA E545K
    Breast Cancer
    GDC-0941
    Sensitive
    :
    D
    PIK3CA E545K
    Breast Cancer
    MK-2206
    Sensitive
    :
    D
    PIK3CA E545K
    Breast Cancer
    lapatinib
    Sensitive
    :
    D
    PIK3CA E545K
    HER2 Positive Breast Cancer
    ado-trastuzumab emtansine
    Sensitive
    :
    D
    PIK3CA E545K
    Breast Cancer
    trastuzumab + lapatinib
    Resistant
    :
    D
    PIK3CA E545K
    Thyroid Gland Papillary Carcinoma
    MK-2206
    Sensitive
    :
    D
    PIK3CA E545K
    Squamous Cell Carcinoma of Head and Neck
    RTB101
    Sensitive
    :
    D
    PIK3CA E545K
    Squamous Cell Carcinoma of Head and Neck
    BMS-722782
    Resistant
    :
    D
    PIK3CA E545K
    Squamous Cell Carcinoma of Head and Neck
    trametinib
    Resistant
    :
    D
    PIK3CA E545K
    Squamous Cell Carcinoma of Head and Neck
    GDC-0941
    Resistant
    :
    D
    PIK3CA E545K
    Squamous Cell Carcinoma of Head and Neck
    rigosertib
    Sensitive
    :
    D
    PIK3CA E545K
    Squamous Cell Carcinoma of Head and Neck
    GDC-0032
    Sensitive
    :
    D
    PIK3CA E545K
    Melanoma
    vemurafenib
    Resistant
    :
    D
    PIK3CA E545K
    Hepatocellular Cancer
    alpelisib
    Sensitive
    :
    D
    PIK3CA E545K
    Hormone Receptor Positive Breast Cancer
    abemaciclib + RLY-2608
    Sensitive
    :
    D
    PIK3CA E545K
    Hormone Receptor Positive Breast Cancer
    palbociclib + RLY-2608
    Sensitive
    :
    D
    PIK3CA E545K
    Hormone Receptor Positive Breast Cancer
    RLY-2608
    Resistant
    :
    D