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BIOMARKER:

PIK3CA E545K

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Other names: PIK3CA, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, Phosphoinositide-3-kinase, catalytic, alpha polypeptide, Serine/threonine protein kinase PIK3CA, PtdIns-3-kinase subunit P110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 KDa catalytic subunit alpha, Phosphatidylinositol 3-kinase, Catalytic, 110-KD, alpha, PI3-kinase P110 subunit alpha, PI3-kinase subunit alpha, PtdIns-3-kinase subunit alpha, PI3Kalpha, P110alpha, PI3K
Entrez ID:
Related biomarkers:
PIK3CA E545K
Colorectal Cancer
cetuximab
Resistant
:
C3
PIK3CA E545K
Non Small Cell Lung Cancer
osimertinib
Resistant
:
C3
PIK3CA E545K
Ovarian Cancer
TAS-117
Sensitive
:
C3
PIK3CA E545K
Breast Cancer
olaparib + durvalumab + AZD5363
Sensitive
:
C3
PIK3CA E545K
Gastric Cancer
CYH33
Sensitive
:
C4
PIK3CA E545K
Breast Cancer
CYH33
Sensitive
:
C4
PIK3CA E545K
Ovarian Cancer
CYH33
Sensitive
:
C4
PIK3CA E545K
Breast Cancer
GDC-0941
Sensitive
:
D
PIK3CA E545K
Breast Cancer
MK-2206
Sensitive
:
D
PIK3CA E545K
Breast Cancer
lapatinib
Sensitive
:
D
PIK3CA E545K
HER2 Positive Breast Cancer
ado-trastuzumab emtansine
Sensitive
:
D
PIK3CA E545K
Breast Cancer
trastuzumab + lapatinib
Resistant
:
D
PIK3CA E545K
Thyroid Gland Papillary Carcinoma
MK-2206
Sensitive
:
D
PIK3CA E545K
Squamous Cell Carcinoma of Head and Neck
RTB101
Sensitive
:
D
PIK3CA E545K
Squamous Cell Carcinoma of Head and Neck
BMS-722782
Resistant
:
D
PIK3CA E545K
Squamous Cell Carcinoma of Head and Neck
trametinib
Resistant
:
D
PIK3CA E545K
Squamous Cell Carcinoma of Head and Neck
GDC-0941
Resistant
:
D
PIK3CA E545K
Squamous Cell Carcinoma of Head and Neck
rigosertib
Sensitive
:
D
PIK3CA E545K
Squamous Cell Carcinoma of Head and Neck
GDC-0032
Sensitive
:
D
PIK3CA E545K
Melanoma
vemurafenib
Resistant
:
D
PIK3CA E545K
Hepatocellular Cancer
alpelisib
Sensitive
:
D
PIK3CA E545K
Hormone Receptor Positive Breast Cancer
abemaciclib + RLY-2608
Sensitive
:
D
PIK3CA E545K
Hormone Receptor Positive Breast Cancer
palbociclib + RLY-2608
Sensitive
:
D
PIK3CA E545K
Hormone Receptor Positive Breast Cancer
RLY-2608
Resistant
:
D