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BIOMARKER:

NRAS mutation + BRAF mutation

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Other names: BRAF, B-raf proto-oncogene, B-raf proto-oncogene, Serine/threonine kinase, V-Raf murine sarcoma viral oncogene homolog B, Serine/threonine-protein kinase B-Raf, Proto-oncogene B-Raf, BRAF1, RAFB1, B-raf proto-oncogene Serine/threonine-protein kinase, Murine sarcoma viral (V-Raf) oncogene homolog B1, B-raf serine/threonine-protein, 94 KDa B-raf protein, B-RAF1, NRAS1, N-Ras Protein Part 4, Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog, NRAS, Neuroblastoma RAS Viral Oncogene Homolog, NRAS Proto
Entrez ID:
NRAS mutation + BRAF mutation
CRC
nivolumab
Sensitive: C3 – Early Trials
NRAS mutation + BRAF mutation
Ampulla of Vater Carcinoma
MEK inhibitor
Sensitive: C4 – Case Studies
NRAS mutation + BRAF mutation
NSCLC
trametinib
Resistant: D – Preclinical
NRAS mutation + BRAF mutation
Melanoma
SCH772984
Sensitive: D – Preclinical