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BIOMARKER:
PIK3CA mutation
i
Other names:
PIK3CA, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, Phosphoinositide-3-kinase, catalytic, alpha polypeptide, Serine/threonine protein kinase PIK3CA, PtdIns-3-kinase subunit P110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 KDa catalytic subunit alpha, Phosphatidylinositol 3-kinase, Catalytic, 110-KD, alpha, PI3-kinase P110 subunit alpha, PI3-kinase subunit alpha, PtdIns-3-kinase subunit alpha, PI3Kalpha, P110alpha, PI3K
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Entrez ID:
5290
Related biomarkers:
Expression
Mutation
CNA
Others
‹
›
Related tests:
Lung Cancer 8-Gene Kit
cobas® PIK3CA Mutation Test
Lung Cancer 8-Gene Kit
cobas® PIK3CA Mutation Test
Associations
News
Trials
VERI cancer hierarchy
Reset Filters
PIK3CA mutation
HER2 Negative Breast Cancer
PIK3CA mutation
HER2 Negative Breast Cancer
alpelisib
Sensitive: B - Late Trials
alpelisib
Sensitive
:
B
alpelisib
Sensitive: B - Late Trials
alpelisib
Sensitive
:
B
PIK3CA mutation
Breast Cancer
PIK3CA mutation
Breast Cancer
AN2025
Sensitive: B - Late Trials
AN2025
Sensitive
:
B
AN2025
Sensitive: B - Late Trials
AN2025
Sensitive
:
B
PIK3CA mutation
Breast Cancer
PIK3CA mutation
Breast Cancer
alpelisib
Sensitive: B - Late Trials
alpelisib
Sensitive
:
B
alpelisib
Sensitive: B - Late Trials
alpelisib
Sensitive
:
B
PIK3CA mutation
Triple Negative Breast Cancer
PIK3CA mutation
Triple Negative Breast Cancer
RG7440
Resistant: B - Late Trials
RG7440
Resistant
:
B
RG7440
Resistant: B - Late Trials
RG7440
Resistant
:
B
PIK3CA mutation
Colorectal Cancer
PIK3CA mutation
Colorectal Cancer
panitumumab
Resistant: B - Late Trials
panitumumab
Resistant
:
B
panitumumab
Resistant: B - Late Trials
panitumumab
Resistant
:
B
PIK3CA mutation
HER2 Positive Breast Cancer
PIK3CA mutation
HER2 Positive Breast Cancer
neratinib
Resistant: B - Late Trials
neratinib
Resistant
:
B
neratinib
Resistant: B - Late Trials
neratinib
Resistant
:
B
PIK3CA mutation
HER2 Positive Breast Cancer
PIK3CA mutation
HER2 Positive Breast Cancer
lapatinib
Resistant: B - Late Trials
lapatinib
Resistant
:
B
lapatinib
Resistant: B - Late Trials
lapatinib
Resistant
:
B
PIK3CA mutation
HER2 Positive Breast Cancer
PIK3CA mutation
HER2 Positive Breast Cancer
trastuzumab
Resistant: B - Late Trials
trastuzumab
Resistant
:
B
trastuzumab
Resistant: B - Late Trials
trastuzumab
Resistant
:
B
PIK3CA mutation
Colorectal Cancer
PIK3CA mutation
Colorectal Cancer
atezolizumab + cobimetinib
Sensitive: B - Late Trials
atezolizumab + cobimetinib
Sensitive
:
B
atezolizumab + cobimetinib
Sensitive: B - Late Trials
atezolizumab + cobimetinib
Sensitive
:
B
PIK3CA mutation
HER2 Positive Breast Cancer
PIK3CA mutation
HER2 Positive Breast Cancer
everolimus
Sensitive: B - Late Trials
everolimus
Sensitive
:
B
everolimus
Sensitive: B - Late Trials
everolimus
Sensitive
:
B
PIK3CA mutation
Non Small Cell Lung Cancer
PIK3CA mutation
Non Small Cell Lung Cancer
erlotinib
Resistant: B - Late Trials
erlotinib
Resistant
:
B
erlotinib
Resistant: B - Late Trials
erlotinib
Resistant
:
B
PIK3CA mutation
HER2 Positive Breast Cancer
PIK3CA mutation
HER2 Positive Breast Cancer
trastuzumab + pertuzumab + alpelisib
Sensitive: B - Late Trials
trastuzumab + pertuzumab + alpelisib
Sensitive
:
B
trastuzumab + pertuzumab + alpelisib
Sensitive: B - Late Trials
trastuzumab + pertuzumab + alpelisib
Sensitive
:
B
PIK3CA mutation
Solid Tumor
PIK3CA mutation
Solid Tumor
GDC-0084
Sensitive: B - Late Trials
GDC-0084
Sensitive
:
B
GDC-0084
Sensitive: B - Late Trials
GDC-0084
Sensitive
:
B
PIK3CA mutation
HER2 Positive Breast Cancer
PIK3CA mutation
HER2 Positive Breast Cancer
pertuzumab + ado-trastuzumab emtansine
Resistant: B - Late Trials
pertuzumab + ado-trastuzumab emtansine
Resistant
:
B
pertuzumab + ado-trastuzumab emtansine
Resistant: B - Late Trials
pertuzumab + ado-trastuzumab emtansine
Resistant
:
B
PIK3CA mutation
Gastric Cancer
PIK3CA mutation
Gastric Cancer
alpelisib
Sensitive: C2 – Inclusion Criteria
alpelisib
Sensitive
:
C2
alpelisib
Sensitive: C2 – Inclusion Criteria
alpelisib
Sensitive
:
C2
PIK3CA mutation
HER2 Positive Breast Cancer
PIK3CA mutation
HER2 Positive Breast Cancer
trastuzumab + MEN1611
Sensitive: C2 – Inclusion Criteria
trastuzumab + MEN1611
Sensitive
:
C2
trastuzumab + MEN1611
Sensitive: C2 – Inclusion Criteria
trastuzumab + MEN1611
Sensitive
:
C2
PIK3CA mutation
Uterine Cancer
PIK3CA mutation
Uterine Cancer
copanlisib
Sensitive: C2 – Inclusion Criteria
copanlisib
Sensitive
:
C2
copanlisib
Sensitive: C2 – Inclusion Criteria
copanlisib
Sensitive
:
C2
PIK3CA mutation
HER2 Positive Breast Cancer
PIK3CA mutation
HER2 Positive Breast Cancer
MEN1611
Sensitive: C2 – Inclusion Criteria
MEN1611
Sensitive
:
C2
MEN1611
Sensitive: C2 – Inclusion Criteria
MEN1611
Sensitive
:
C2
PIK3CA mutation
Breast Cancer
PIK3CA mutation
Breast Cancer
palbociclib
Sensitive: C2 – Inclusion Criteria
palbociclib
Sensitive
:
C2
palbociclib
Sensitive: C2 – Inclusion Criteria
palbociclib
Sensitive
:
C2
PIK3CA mutation
Ovarian Cancer
PIK3CA mutation
Ovarian Cancer
CYH33
Sensitive: C2 – Inclusion Criteria
CYH33
Sensitive
:
C2
CYH33
Sensitive: C2 – Inclusion Criteria
CYH33
Sensitive
:
C2
PIK3CA mutation
Breast Cancer
PIK3CA mutation
Breast Cancer
MEN1611
Sensitive: C2 – Inclusion Criteria
MEN1611
Sensitive
:
C2
MEN1611
Sensitive: C2 – Inclusion Criteria
MEN1611
Sensitive
:
C2
PIK3CA mutation
Breast Cancer
PIK3CA mutation
Breast Cancer
CYH33
Sensitive: C2 – Inclusion Criteria
CYH33
Sensitive
:
C2
CYH33
Sensitive: C2 – Inclusion Criteria
CYH33
Sensitive
:
C2
PIK3CA mutation
Breast Cancer
PIK3CA mutation
Breast Cancer
GDC-0032
Sensitive: C2 – Inclusion Criteria
GDC-0032
Sensitive
:
C2
GDC-0032
Sensitive: C2 – Inclusion Criteria
GDC-0032
Sensitive
:
C2
PIK3CA mutation
Gastric Cancer
PIK3CA mutation
Gastric Cancer
capivasertib
Sensitive: C2 – Inclusion Criteria
capivasertib
Sensitive
:
C2
capivasertib
Sensitive: C2 – Inclusion Criteria
capivasertib
Sensitive
:
C2
PIK3CA mutation
Squamous Cell Carcinoma of Head and Neck
PIK3CA mutation
Squamous Cell Carcinoma of Head and Neck
alpelisib
Sensitive: C2 – Inclusion Criteria
alpelisib
Sensitive
:
C2
alpelisib
Sensitive: C2 – Inclusion Criteria
alpelisib
Sensitive
:
C2
PIK3CA mutation
Hormone Receptor Positive Breast Cancer
PIK3CA mutation
Hormone Receptor Positive Breast Cancer
alpelisib
Sensitive: C2 – Inclusion Criteria
alpelisib
Sensitive
:
C2
alpelisib
Sensitive: C2 – Inclusion Criteria
alpelisib
Sensitive
:
C2
PIK3CA mutation
Solid Tumor
PIK3CA mutation
Solid Tumor
copanlisib
Sensitive: C2 – Inclusion Criteria
copanlisib
Sensitive
:
C2
copanlisib
Sensitive: C2 – Inclusion Criteria
copanlisib
Sensitive
:
C2
PIK3CA mutation
Solid Tumor
PIK3CA mutation
Solid Tumor
ARQ 751
Sensitive: C2 – Inclusion Criteria
ARQ 751
Sensitive
:
C2
ARQ 751
Sensitive: C2 – Inclusion Criteria
ARQ 751
Sensitive
:
C2
PIK3CA mutation
Solid Tumor
PIK3CA mutation
Solid Tumor
temsirolimus
Sensitive: C2 – Inclusion Criteria
temsirolimus
Sensitive
:
C2
temsirolimus
Sensitive: C2 – Inclusion Criteria
temsirolimus
Sensitive
:
C2
PIK3CA mutation
HER2 Positive Breast Cancer
PIK3CA mutation
HER2 Positive Breast Cancer
trastuzumab + alpelisib
Sensitive: C2 – Inclusion Criteria
trastuzumab + alpelisib
Sensitive
:
C2
trastuzumab + alpelisib
Sensitive: C2 – Inclusion Criteria
trastuzumab + alpelisib
Sensitive
:
C2
PIK3CA mutation
Non Small Cell Lung Cancer
PIK3CA mutation
Non Small Cell Lung Cancer
U3-1402
Sensitive: C3 – Early Trials
U3-1402
Sensitive
:
C3
U3-1402
Sensitive: C3 – Early Trials
U3-1402
Sensitive
:
C3
PIK3CA mutation
Triple Negative Breast Cancer
PIK3CA mutation
Triple Negative Breast Cancer
everolimus
Sensitive: C3 – Early Trials
everolimus
Sensitive
:
C3
everolimus
Sensitive: C3 – Early Trials
everolimus
Sensitive
:
C3
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