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BIOMARKER:

EGFR mutation + BRAF V600E

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Other names: EGFR, ERBB, ERBB1, Epidermal growth factor receptor, BRAF, B-raf proto-oncogene, B-raf proto-oncogene, Serine/threonine kinase, V-Raf murine sarcoma viral oncogene homolog B, Serine/threonine-protein kinase B-Raf, Proto-oncogene B-Raf, BRAF1, RAFB1, B-raf proto-oncogene Serine/threonine-protein kinase, Murine sarcoma viral (V-Raf) oncogene homolog B1, B-raf serine/threonine-protein, 94 KDa B-raf protein, B-RAF1
Entrez ID:
EGFR mutation + BRAF V600E
CRC
cetuximab + alpelisib + encorafenib
Resistant: C3 – Early Trials
EGFR mutation + BRAF V600E
CRC
cetuximab + encorafenib + binimetinib
Resistant: C3 – Early Trials
EGFR mutation + BRAF V600E
CRC
cetuximab + encorafenib
Resistant: C3 – Early Trials
EGFR mutation + BRAF V600E
NSCLC
trametinib + osimertinib + dabrafenib
Sensitive: C4 – Case Studies
EGFR mutation + BRAF V600E
LUAD
trametinib + erlotinib
Sensitive: D – Preclinical
EGFR mutation + BRAF V600E
LUAD
erlotinib
Resistant: D – Preclinical