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BIOMARKER:

BRAF V600E + PIK3CA mutation

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Entrez ID:

Related biomarkers:

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PIK3CA mutation + HR positive (16)

PIK3CA mutation + ER positive (10)

HER-2 amplification + RAS wild-type + BRAF wild-type (9)

PIK3CA mutation + PTEN deletion (5)

BRAF V600K + LDH elevation (3)

ER positive + PIK3CA H1047R (3)

HR-positive + PIK3CA wild-type (3)

PIK3CA exon 20 mutation + HR positive (3)

BRAF V600E + MSI-H (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)

BRAF V600E + ROS1 fusion (2)

BRAF mutation + MET amplification (2)

BRAF mutation + MSI-L/dMMR (2)

BRAF mutation + TERT overexpression (2)

BRAF wild-type + HER-2 positive (2)

EZR overexpression + BRAF V600E (2)

IDH1 mutation + BRAF V600E (2)

IDH1 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)

IDH2 mutation + BRAF V600E (2)

IDH2 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)

MSI-H/dMMR + BRAF V600E (2)

PD-L1 expression + NRAS Q61R + BRAF D594N (2)

PD-L1 overexpression + BRAF V600E (2)

RAS wild-type + BRAF wild-type + HER-2 positive (2)

PIK3CA H1047R + PIK3C2B amplification (2)

PIK3CA mutation + ER negative (2)

PIK3CA mutation + HR negative (2)

PIK3CA mutation + MSI-L/dMMR (2)

TMB-H + PIK3CA mutation (2)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)

BRAF E501Q + PD-L1 negative (1)

BRAF V600 + LDH elevation (1)

BRAF V600 + LDH elevation + PD-L1 negative (1)

BRAF V600E + CDKN2A deletion + MYCN amplification (1)

BRAF V600E + CDKN2A deletion + RB1 expression (1)

BRAF V600E + EGFR expression (1)

BRAF V600E + PTEN deletion (1)

BRAF V600E + SOX2 amplification (1)

BRAF V600K + CDKN2A deletion + RB1 expression (1)

BRAF mutation + PD-L1 overexpression (1)

BRAF mutation + TMB-H (1)

BRAF mutation + TMB-L + MSI-L/dMMR (1)

BRAF negative + GKAP1-NTRK2 exon 10-16 in-frame fusion (1)

BRAF wild-type + HGF elevation (1)

CD8 elevation + BRAF V600 (1)

Chr t(11;14) + BRAF mutation (1)

EGFR exon 19 deletion + BRAF G464A (1)

EGFR overexpression + BRAF V600E (1)

EGFR overexpression + BRAF mutation (1)

HER-2 amplification + BRAF wild-type (1)

HR positive + BRAF V600E (1)

KIAA1549-BRAF fusion + MET amplification (1)

KIAA1549-BRAF fusion + PTEN deletion (1)

KRAS wild-type + BRAF V600E (1)

LDH elevation + BRAF mutation (1)

MAP2K1 mutation + BRAF wild-type (1)

MSI-H/dMMR + BRAF Mutation (1)

MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)

NRAS mutation + BRAF wild-type (1)

PD-L1 expression + BRAF negative (1)

PIK3CA mutation + BRAF wild-type (1)

SEMA6A overexpression + BRAF mutation (1)

SRC overexpression + BRAF V600E (1)

TNFAIP3 overexpression + BRAF mutation (1)

CCNE1 overexpression + PIK3CA muattion + ER positive (1)

CCNE2 overexpression + PIK3CA mutation + ER positive (1)

EGFR L858R + HER-2 amplification + PIK3CA overexpression (1)

EGFR exon 19 deletion + PTEN deletion + PIK3CA overexpression (1)

ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)

ER positive + ESR1 mutation + PIK3CA mutation (1)

ESR1 mutation + PIK3CA mutation + HR positive (1)

HR positive + PIK3CA exon 10 mutation (1)

HRAS overexpression + PIK3CA amplification (1)

HRAS overexpression + PIK3CA mutation (1)

KRAS mutation + PIK3CA wild-type (1)

MET amplification + PIK3CA mutation (1)

MTAP deletion + PIK3CA mutation (1)

MYB fusion + PIK3CA mutation (1)

PD-L1 expression + PIK3CA mutation (1)

PIK3CA E542K + HR positive (1)

PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)

PIK3CA H1047R + HER-2 amplification (1)

PIK3CA R88Q + PD-L1 expression (1)

PIK3CA amplification + PIK3CA mutation + HR positive (1)

PIK3CA exon 7 mutation + HR positive (1)

PIK3CA exon 9 mutation + HR positive (1)

PIK3CA mutation + ALK fusion (1)

PIK3CA mutation + ALK positive (1)

PIK3CA mutation + ESR1 wild-type (1)

PIK3CA mutation + HER-2 amplification (1)

PIK3CA mutation + HER-2 positive (1)

PIK3CA mutation + HR positive + HER-2 negative (1)

PIK3CA mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)

PIK3CA mutation + PTEN underexpression (1)

PIK3CA mutation + RAS wild-type (1)

PIK3CA mutation + TTN mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)

PIK3CA wild-type+ ESR1 wild-type (1)

SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)

PD-L1 overexpression + BRAF mutation (0)

ER negative + HER-2 positive + PIK3CA H1047R (0)

MYB fusion + PIK3CA amplification (0)

PIK3CA E453K + HER-2 positive (0)

PIK3CA E542K + HER-2 positive (0)

PIK3CA E542Q + HER-2 positive (0)

PIK3CA H1047L + HER-2 positive (0)

PIK3CA H1047R + HER-2 positive (0)

PIK3CA N345K + HER-2 positive (0)

PIK3CA amplification + HER-2 positive (0)

PIK3CA amplification + PTEN deletion (0)

PIK3CA mutation + ER negative + PGR positive (0)

PIK3CA mutation + PTEN expression (0)

PIK3CA mutation + TMB-L + MSI-L/dMMR (0)

PIK3CA mutation + HR positive (16)

PIK3CA mutation + ER positive (10)

HER-2 amplification + RAS wild-type + BRAF wild-type (9)

PIK3CA mutation + PTEN deletion (5)

BRAF V600K + LDH elevation (3)

ER positive + PIK3CA H1047R (3)

HR-positive + PIK3CA wild-type (3)

PIK3CA exon 20 mutation + HR positive (3)

BRAF V600E + MSI-H (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PD-L1 expression (2)

BRAF V600E + PIK3CA mutation + SMAD4 mutation + MSI-H/dMMR (2)

BRAF V600E + ROS1 fusion (2)

BRAF mutation + MET amplification (2)

BRAF mutation + MSI-L/dMMR (2)

BRAF mutation + TERT overexpression (2)

BRAF wild-type + HER-2 positive (2)

EZR overexpression + BRAF V600E (2)

IDH1 mutation + BRAF V600E (2)

IDH1 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)

IDH2 mutation + BRAF V600E (2)

IDH2 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (2)

MSI-H/dMMR + BRAF V600E (2)

PD-L1 expression + NRAS Q61R + BRAF D594N (2)

PD-L1 overexpression + BRAF V600E (2)

RAS wild-type + BRAF wild-type + HER-2 positive (2)

PIK3CA H1047R + PIK3C2B amplification (2)

PIK3CA mutation + ER negative (2)

PIK3CA mutation + HR negative (2)

PIK3CA mutation + MSI-L/dMMR (2)

TMB-H + PIK3CA mutation (2)

ALK fusion + EGFR exon 19 deletion + BRAF G466V + MAP2K1 F129L (1)

ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs (1)

BRAF E501Q + PD-L1 negative (1)

BRAF V600 + LDH elevation (1)

BRAF V600 + LDH elevation + PD-L1 negative (1)

BRAF V600E + CDKN2A deletion + MYCN amplification (1)

BRAF V600E + CDKN2A deletion + RB1 expression (1)

BRAF V600E + EGFR expression (1)

BRAF V600E + PTEN deletion (1)

BRAF V600E + SOX2 amplification (1)

BRAF V600K + CDKN2A deletion + RB1 expression (1)

BRAF mutation + PD-L1 overexpression (1)

BRAF mutation + TMB-H (1)

BRAF mutation + TMB-L + MSI-L/dMMR (1)

BRAF negative + GKAP1-NTRK2 exon 10-16 in-frame fusion (1)

BRAF wild-type + HGF elevation (1)

CD8 elevation + BRAF V600 (1)

Chr t(11;14) + BRAF mutation (1)

EGFR exon 19 deletion + BRAF G464A (1)

EGFR overexpression + BRAF V600E (1)

EGFR overexpression + BRAF mutation (1)

HER-2 amplification + BRAF wild-type (1)

HR positive + BRAF V600E (1)

KIAA1549-BRAF fusion + MET amplification (1)

KIAA1549-BRAF fusion + PTEN deletion (1)

KRAS wild-type + BRAF V600E (1)

LDH elevation + BRAF mutation (1)

MAP2K1 mutation + BRAF wild-type (1)

MSI-H/dMMR + BRAF Mutation (1)

MSI-H/dMMR + KRAS wild-type + BRAF wild-type (1)

NRAS mutation + BRAF wild-type (1)

PD-L1 expression + BRAF negative (1)

PIK3CA mutation + BRAF wild-type (1)

SEMA6A overexpression + BRAF mutation (1)

SRC overexpression + BRAF V600E (1)

TNFAIP3 overexpression + BRAF mutation (1)

CCNE1 overexpression + PIK3CA muattion + ER positive (1)

CCNE2 overexpression + PIK3CA mutation + ER positive (1)

EGFR L858R + HER-2 amplification + PIK3CA overexpression (1)

EGFR exon 19 deletion + PTEN deletion + PIK3CA overexpression (1)

ER negative + HER-2 positive + PGR positive + PIK3CA mutation (1)

ER positive + ESR1 mutation + PIK3CA mutation (1)

ESR1 mutation + PIK3CA mutation + HR positive (1)

HR positive + PIK3CA exon 10 mutation (1)

HRAS overexpression + PIK3CA amplification (1)

HRAS overexpression + PIK3CA mutation (1)

KRAS mutation + PIK3CA wild-type (1)

MET amplification + PIK3CA mutation (1)

MTAP deletion + PIK3CA mutation (1)

MYB fusion + PIK3CA mutation (1)

PD-L1 expression + PIK3CA mutation (1)

PIK3CA E542K + HR positive (1)

PIK3CA E542Q + TMB-H + MSI-H/dMMR (1)

PIK3CA H1047R + HER-2 amplification (1)

PIK3CA R88Q + PD-L1 expression (1)

PIK3CA amplification + PIK3CA mutation + HR positive (1)

PIK3CA exon 7 mutation + HR positive (1)

PIK3CA exon 9 mutation + HR positive (1)

PIK3CA mutation + ALK fusion (1)

PIK3CA mutation + ALK positive (1)

PIK3CA mutation + ESR1 wild-type (1)

PIK3CA mutation + HER-2 amplification (1)

PIK3CA mutation + HER-2 positive (1)

PIK3CA mutation + HR positive + HER-2 negative (1)

PIK3CA mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)

PIK3CA mutation + PTEN underexpression (1)

PIK3CA mutation + RAS wild-type (1)

PIK3CA mutation + TTN mutation + IDH2 mutation + Chr del(1q) + Chr del(17) (1)

PIK3CA wild-type+ ESR1 wild-type (1)

SQSTM1-NTRK1 + PIK3CA E545K + TP53 L145R + PD-L1 overexpression (1)

PD-L1 overexpression + BRAF mutation (0)

ER negative + HER-2 positive + PIK3CA H1047R (0)

MYB fusion + PIK3CA amplification (0)

PIK3CA E453K + HER-2 positive (0)

PIK3CA E542K + HER-2 positive (0)

PIK3CA E542Q + HER-2 positive (0)

PIK3CA H1047L + HER-2 positive (0)

PIK3CA H1047R + HER-2 positive (0)

PIK3CA N345K + HER-2 positive (0)

PIK3CA amplification + HER-2 positive (0)

PIK3CA amplification + PTEN deletion (0)

PIK3CA mutation + ER negative + PGR positive (0)

PIK3CA mutation + PTEN expression (0)

PIK3CA mutation + TMB-L + MSI-L/dMMR (0)

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BRAF V600E + PIK3CA mutation	Colorectal Cancer	BRAF V600E + PIK3CA mutation	Colorectal Cancer	cetuximab + alpelisib + encorafenib Resistant: C3 – Early Trials cetuximab + alpelisib + encorafenib Resistant : C3	cetuximab + alpelisib + encorafenib Resistant: C3 – Early Trials cetuximab + alpelisib + encorafenib Resistant : C3
BRAF V600E + PIK3CA mutation	Colorectal Cancer	BRAF V600E + PIK3CA mutation	Colorectal Cancer	cetuximab + binimetinib + encorafenib Resistant: C3 – Early Trials cetuximab + binimetinib + encorafenib Resistant : C3	cetuximab + binimetinib + encorafenib Resistant: C3 – Early Trials cetuximab + binimetinib + encorafenib Resistant : C3
BRAF V600E + PIK3CA mutation	Colorectal Cancer	BRAF V600E + PIK3CA mutation	Colorectal Cancer	cetuximab + encorafenib Resistant: C3 – Early Trials cetuximab + encorafenib Resistant : C3	cetuximab + encorafenib Resistant: C3 – Early Trials cetuximab + encorafenib Resistant : C3
BRAF V600E + PIK3CA mutation	Astrocytoma	BRAF V600E + PIK3CA mutation	Astrocytoma	vemurafenib + everolimus Sensitive: C4 – Case Studies vemurafenib + everolimus Sensitive : C4	vemurafenib + everolimus Sensitive: C4 – Case Studies vemurafenib + everolimus Sensitive : C4