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BIOMARKER:

PIK3CA E542K

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Other names: PIK3CA, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, Phosphoinositide-3-kinase, catalytic, alpha polypeptide, Serine/threonine protein kinase PIK3CA, PtdIns-3-kinase subunit P110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 KDa catalytic subunit alpha, Phosphatidylinositol 3-kinase, Catalytic, 110-KD, alpha, PI3-kinase P110 subunit alpha, PI3-kinase subunit alpha, PtdIns-3-kinase subunit alpha, PI3Kalpha, P110alpha, PI3K
Entrez ID:
Related biomarkers:
PIK3CA E542K
HER2 Positive Breast Cancer
trastuzumab
Sensitive: B - Late Trials
PIK3CA E542K
HER2 Positive Breast Cancer
PF-05212384 + Herzuma (trastuzumab biosimilar)
Sensitive: C3 – Early Trials
PIK3CA E542K
LUAD
crizotinib
Sensitive: C3 – Early Trials
PIK3CA E542K
CRC
cetuximab
Resistant: C3 – Early Trials
PIK3CA E542K
SCCHN
GDC-0980
Sensitive: C3 – Early Trials
PIK3CA E542K
Soft Tissue Sarcoma
trametinib + pazopanib
Sensitive: C4 – Case Studies
PIK3CA E542K
Breast Cancer
sirolimus
Sensitive: D – Preclinical
PIK3CA E542K
SCCHN
GDC-0032
Sensitive: D – Preclinical
PIK3CA E542K
SCCHN
RTB101
Sensitive: D – Preclinical