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BIOMARKER:

ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs

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Entrez ID:

Related biomarkers:

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BRAF V600E (255)

BRAF mutation (129)

BRAF V600 (106)

ALK rearrangement (43)

BRAF V600K (25)

BRAF wild-type (25)

ALK mutation (20)

ALK wild-type (18)

STRN-ALK rearrangement (10)

ALK translocation (9)

RAS wild-type + BRAF wild-type (7)

EGFR wild-type + ALK wild-type (7)

BRAF V600E + RNF43 mutation (6)

EGFR mutation + BRAF V600E (6)

EML4-ALK rearrangement (5)

BRAF V600E + PIK3CA mutation (4)

NRAS mutation + BRAF mutation (4)

ALK G1202del (4)

ALK rearrangement + TP53 mutation (4)

BRAF T1799A (3)

BRAF V600E + TERT mutation (3)

BRAF delNVTAP (3)

NRAS Q61K + BRAF V600E (3)

TERT mutation + BRAF V600E (3)

TYRO3 mutation + ALK mutation (3)

BRAF V600E + MAP2K1 I111S (2)

BRAF mutation + MEK1 P124L (2)

BRAF mutation + NF1 mutation (2)

BRAF rearrangement (2)

EGFR mutation + BRAF V600 (2)

IDH1 wild-type + BRAF mutation (2)

KRAS G13D + BRAF mutation (2)

MYD88 L265P + BRAF V600E (2)

NRAS G12C + BRAF mutation (2)

ALK C1156Y + ALK I1171T (2)

ALK C1156Y + ALK L1198F (2)

ALK F1174L + ALK G1202R (2)

DCTN1-ALK rearrangement + ALK-CLIP4 rearrangement (2)

AKT1 E17K + BRAF V600 (1)

BRAF 486_490 del (1)

BRAF G466E + NF1 Y2285fs*5 + NF1 Y2640fs*3 + TP53 D281Y (1)

BRAF G466V + KIT K509Q (1)

BRAF N486-P490del + TP53 V157G (1)

BRAF V600 wild-type (1)

BRAF V600DK601del (1)

BRAF V600E + BRAF G469A + BRAF G469V (1)

BRAF V600E + BRAF K601_W604del (1)

BRAF V600E + BRAF L514V (1)

BRAF V600E + BRAF V600K (1)

BRAF V600E + KRAS G12R (1)

BRAF V600E + MSI-H/dMMR (1)

BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L (1)

BRAF V600_K601delinsE (1)

BRAF mutation + EGFR mutation (1)

BRAF mutation + MAP2K1 mutation (1)

BRAF mutation + RAS mutation (1)

BRAF mutation + TERT −124C>T (1)

BRAF mutation + TERT −138CC>TT (1)

BRAF mutation + TERT −139CC>TT (1)

BRAF mutation + TERT −146C>T (1)

BRAF mutation + TET2 mutation (1)

BRAF mutation + TP53 mutation (1)

BRAF wild-type + NRAS wild-type (1)

EGFR T790M + BRAF V600E (1)

EGFR exon 19 deletion + BRAF V600E (1)

EGFR mutation + BRAF G469A (1)

EGFR mutation + BRAF mutation + TP53 mutation (1)

KRAS G12A + BRAF D549N (1)

KRAS G12V + BRAF V600E (1)

MAP2K1 V211D + BRAF mutation (1)

NRAS G12C + BRAF V600E + BRAF V600D (1)

NRAS G13D + BRAF V600E (1)

RAS wild-type + BRAF wild-type + MAP2K1 N57K (1)

ROS1 rearrangement + BRAF V600E (1)

TERT promoter mutation + BRAF V600 (1)

ALK C1156Y + ALK G1202R (1)

ALK G1202R + ALK F1174L + ALK T1151M (1)

ALK L1152R + EGFR mutation (1)

ALK L1196M + ALK C1156Y (1)

ALK L1196M + ALK G1202R (1)

ALK L1196M + ALK L1198F (1)

ALK L1198F + ALK G1202R (1)

ALK TKD mutation (1)

ALK rearrangement + ALK L1196M + TP53 mutation (1)

ALK rearrangement + ALK R1275Q + TP53 mutation (1)

ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)

ALK rearrangement + EGFR D761N + KRAS V14I (1)

ALK rearrangement + HER-2 mutation (1)

ALK rearrangement + KRAS mutation (1)

ALK rearrangement + PIK3CA mutation (1)

ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)

ALK rearrangement + TP53 wild-type (1)

EGFR L858R + ALK R1275Q (1)

EGFR L858R + ALK rearrangement (1)

EGFR exon 19 deletion + ALK mutation (1)

EGFR mutation + ALK mutation (1)

EGFR wild-type + ALK wild-type + ROS1 wild-type (1)

EGFR wild-type + ALK wild-type + STK11 mutation (1)

EML4-ALK I1171N + EML4-ALK L1196M (1)

EML4-ALK I1171N + EML4-ALK L1196M + EML4-ALK G1202R (1)

LMO7-ALK rearrangement (1)

PLEKHH2-ALK rearrangement (1)

RMST-ALK rearrangement (1)

TP53 G245S + ALK rearrangement (1)

BRAF V600E + TERT mutation (0)

BRAF V600E + KRAS G12D (0)

BRAF V600E + MAP2K1 P124S (0)

BRAF exon 11 mutation (0)

BRAF exon 15 mutation (0)

CDKN2A mutation + BRAF V600E (0)

IDH mutation + BRAF V600E (0)

IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)

ALK mutation + TP53 mutation (0)

BRAF V600E (255)

BRAF mutation (129)

BRAF V600 (106)

ALK rearrangement (43)

BRAF V600K (25)

BRAF wild-type (25)

ALK mutation (20)

ALK wild-type (18)

STRN-ALK rearrangement (10)

ALK translocation (9)

RAS wild-type + BRAF wild-type (7)

EGFR wild-type + ALK wild-type (7)

BRAF V600E + RNF43 mutation (6)

EGFR mutation + BRAF V600E (6)

EML4-ALK rearrangement (5)

BRAF V600E + PIK3CA mutation (4)

NRAS mutation + BRAF mutation (4)

ALK G1202del (4)

ALK rearrangement + TP53 mutation (4)

BRAF T1799A (3)

BRAF V600E + TERT mutation (3)

BRAF delNVTAP (3)

NRAS Q61K + BRAF V600E (3)

TERT mutation + BRAF V600E (3)

TYRO3 mutation + ALK mutation (3)

BRAF V600E + MAP2K1 I111S (2)

BRAF mutation + MEK1 P124L (2)

BRAF mutation + NF1 mutation (2)

BRAF rearrangement (2)

EGFR mutation + BRAF V600 (2)

IDH1 wild-type + BRAF mutation (2)

KRAS G13D + BRAF mutation (2)

MYD88 L265P + BRAF V600E (2)

NRAS G12C + BRAF mutation (2)

ALK C1156Y + ALK I1171T (2)

ALK C1156Y + ALK L1198F (2)

ALK F1174L + ALK G1202R (2)

DCTN1-ALK rearrangement + ALK-CLIP4 rearrangement (2)

AKT1 E17K + BRAF V600 (1)

BRAF 486_490 del (1)

BRAF G466E + NF1 Y2285fs*5 + NF1 Y2640fs*3 + TP53 D281Y (1)

BRAF G466V + KIT K509Q (1)

BRAF N486-P490del + TP53 V157G (1)

BRAF V600 wild-type (1)

BRAF V600DK601del (1)

BRAF V600E + BRAF G469A + BRAF G469V (1)

BRAF V600E + BRAF K601_W604del (1)

BRAF V600E + BRAF L514V (1)

BRAF V600E + BRAF V600K (1)

BRAF V600E + KRAS G12R (1)

BRAF V600E + MSI-H/dMMR (1)

BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L (1)

BRAF V600_K601delinsE (1)

BRAF mutation + EGFR mutation (1)

BRAF mutation + MAP2K1 mutation (1)

BRAF mutation + RAS mutation (1)

BRAF mutation + TERT −124C>T (1)

BRAF mutation + TERT −138CC>TT (1)

BRAF mutation + TERT −139CC>TT (1)

BRAF mutation + TERT −146C>T (1)

BRAF mutation + TET2 mutation (1)

BRAF mutation + TP53 mutation (1)

BRAF wild-type + NRAS wild-type (1)

EGFR T790M + BRAF V600E (1)

EGFR exon 19 deletion + BRAF V600E (1)

EGFR mutation + BRAF G469A (1)

EGFR mutation + BRAF mutation + TP53 mutation (1)

KRAS G12A + BRAF D549N (1)

KRAS G12V + BRAF V600E (1)

MAP2K1 V211D + BRAF mutation (1)

NRAS G12C + BRAF V600E + BRAF V600D (1)

NRAS G13D + BRAF V600E (1)

RAS wild-type + BRAF wild-type + MAP2K1 N57K (1)

ROS1 rearrangement + BRAF V600E (1)

TERT promoter mutation + BRAF V600 (1)

ALK C1156Y + ALK G1202R (1)

ALK G1202R + ALK F1174L + ALK T1151M (1)

ALK L1152R + EGFR mutation (1)

ALK L1196M + ALK C1156Y (1)

ALK L1196M + ALK G1202R (1)

ALK L1196M + ALK L1198F (1)

ALK L1198F + ALK G1202R (1)

ALK TKD mutation (1)

ALK rearrangement + ALK L1196M + TP53 mutation (1)

ALK rearrangement + ALK R1275Q + TP53 mutation (1)

ALK rearrangement + ALK T1151M + ALK L1198F + EGFR A839V (1)

ALK rearrangement + EGFR D761N + KRAS V14I (1)

ALK rearrangement + HER-2 mutation (1)

ALK rearrangement + KRAS mutation (1)

ALK rearrangement + PIK3CA mutation (1)

ALK rearrangement + TP53 R175H + EGFR A839V + PI3KCA mutation (1)

ALK rearrangement + TP53 wild-type (1)

EGFR L858R + ALK R1275Q (1)

EGFR L858R + ALK rearrangement (1)

EGFR exon 19 deletion + ALK mutation (1)

EGFR mutation + ALK mutation (1)

EGFR wild-type + ALK wild-type + ROS1 wild-type (1)

EGFR wild-type + ALK wild-type + STK11 mutation (1)

EML4-ALK I1171N + EML4-ALK L1196M (1)

EML4-ALK I1171N + EML4-ALK L1196M + EML4-ALK G1202R (1)

LMO7-ALK rearrangement (1)

PLEKHH2-ALK rearrangement (1)

RMST-ALK rearrangement (1)

TP53 G245S + ALK rearrangement (1)

BRAF V600E + TERT mutation (0)

BRAF V600E + KRAS G12D (0)

BRAF V600E + MAP2K1 P124S (0)

BRAF exon 11 mutation (0)

BRAF exon 15 mutation (0)

CDKN2A mutation + BRAF V600E (0)

IDH mutation + BRAF V600E (0)

IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)

ALK mutation + TP53 mutation (0)

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ALK rearrangement + ALK I1171N + ALK V1180L + BRCA2 F2801fs

Lung Adenocarcinoma

afatinib + lorlatinib

Sensitive: C4 – Case Studies

afatinib + lorlatinib

afatinib + lorlatinib

Sensitive: C4 – Case Studies

afatinib + lorlatinib