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DRUG:

MYTX-011

i
Other names: MYTX-011
Company:
Mythic Therap
Drug class:
Microtubule inhibitor, c-MET-targeted antibody-drug conjugate
Related drugs:
2ms
Enrollment change
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MET (MET proto-oncogene, receptor tyrosine kinase)
|
MET amplification • MET exon 14 mutation • MET mutation
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MYTX-011
7ms
MYTX-011: A pH-Dependent Anti-c-MET Antibody-Drug Conjugate Designed for Enhanced Payload Delivery to c-MET-Expressing Tumor Cells. (PubMed, Mol Cancer Ther)
These results highlight the potential of MYTX-011 for treating a broader range of patients with NSCLC with c-MET expression than other c-MET-targeting ADCs. A first-in-human study is ongoing to determine the safety, tolerability, and preliminary efficacy of MYTX-011 in patients with NSCLC (NCT05652868).
Journal • Tumor cell
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MET (MET proto-oncogene, receptor tyrosine kinase)
|
MYTX-011
12ms
Trial completion date • Trial primary completion date
|
MET (MET proto-oncogene, receptor tyrosine kinase)
|
MET amplification • MET exon 14 mutation • MET mutation
|
MYTX-011
almost2years
MYTX-011: A novel cMET-targeting antibody drug conjugate (ADC) engineered to increase on-target uptake in and efficacy against cMET expressing tumors (AACR 2023)
PK and toxicity studies in cynomolgus monkeys revealed that MYTX-011 exhibited favorable PK characteristics, and a toxicity profile similar to previously described MMAE-based ADCs. Together, these findings highlight the potential of MYTX-011 as a therapeutic candidate for treating a broader range of cMET+ malignancies than other cMET-ADCs.
Clinical
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MET (MET proto-oncogene, receptor tyrosine kinase)
|
MET expression
|
MYTX-011
almost2years
Enrollment open
|
MET (MET proto-oncogene, receptor tyrosine kinase)
|
MET amplification • MET exon 14 mutation • MET mutation
|
MYTX-011
2years
New P1 trial
|
MET (MET proto-oncogene, receptor tyrosine kinase)
|
MET amplification • MET exon 14 mutation • MET mutation
|
MYTX-011