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    DRUG:

    ASG 5ME

    i
    Other names: ASG 5ME, ASG-5-ME, ASG-5ME
    Company:
    Pfizer
    Drug class:
    Microtubule inhibitor, SLC44A4-targeted antibody-drug conjugate
    Related drugs:
    over4years
    A phase I study of the antibody drug conjugate ASG-5ME, an SLC44A4-targeting antibody carrying auristatin E, in metastatic castration-resistant prostate cancer. (PubMed, Invest New Drugs)
    However, other toxicities were consistent with studies of previous MMAE-containing ADCs. Unconjugated MMAE is a less likely etiology based on prior data.
    P1 data • Journal
    |
    SLC4A4 (Solute carrier family 4 member 4)
    |
    ASG 5ME