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GENE:
CHEK2 (Checkpoint kinase 2)
i
Other names:
CHEK2, bA444G7, CDS1, CHK2, HuCds1, PP1425, RAD53, Checkpoint kinase 2
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Entrez ID:
11200
Related tests:
‹
FoundationOne® CDx (110)
FoundationOne® Liquid CDx (21)
Oncomine™ Pan-Cancer Cell-Free Assay (4)
Guardant360 TissueNext™ (2)
Oncomine™ Comprehensive Assay v3M (2)
Tempus xT Assay (1)
ACTOnco
AVENIO Tumor Tissue CGP Kit
Altera
AmoyDx® HANDLE HRR NGS Panel
AmoyDx® HRD Complete Panel
Archer™ VARIANTPlex™ Pan Solid Tumor panel
BRCANext®
BRCAplus®
BROCA Cancer Risk Panel
BreastNext®
CancerNext ®
CancerNext-Expanded®
ColoNext®
ColoSeq™
CustomNext-Cancer®
Devyser HBOC NGS
Empower™ Hereditary cancer test
GALEAS™ Hereditary Plus
Invitae Common Hereditary Cancers Panel
Labcorp® Plasma Complete™
Myriad myRisk® Hereditary Cancer
NeXT Dx™ Test
NeoLAB® Solid Tumor Liquid Biopsy
Northstar Select™
NovoFocus™ PARPi CDx
OncoGuide™ NCC Oncopanel System
OncoPanel™ Assay
Oncomine Precision Assay
Oncomine Tumor Mutation Load Assay
OvaNext®
ProstateNext®
QVantageᵀᴹ
RenalNext™
SOPHiA DDM HRD Solution
SureSeq™ Pan-Myeloid Panel
Tempus xF+ Panel
Tempus xG+
TruSight Oncology Comprehensive
TruSight Tumor 170 Assay
TumorNext-HRD
VarMap™ Pan-Cancer NGS Panel
FoundationOne® CDx (110)
FoundationOne® Liquid CDx (21)
Oncomine™ Pan-Cancer Cell-Free Assay (4)
Guardant360 TissueNext™ (2)
Oncomine™ Comprehensive Assay v3M (2)
Tempus xT Assay (1)
ACTOnco
AVENIO Tumor Tissue CGP Kit
Altera
AmoyDx® HANDLE HRR NGS Panel
AmoyDx® HRD Complete Panel
Archer™ VARIANTPlex™ Pan Solid Tumor panel
BRCANext®
BRCAplus®
BROCA Cancer Risk Panel
BreastNext®
CancerNext ®
CancerNext-Expanded®
ColoNext®
ColoSeq™
CustomNext-Cancer®
Devyser HBOC NGS
Empower™ Hereditary cancer test
GALEAS™ Hereditary Plus
Invitae Common Hereditary Cancers Panel
Labcorp® Plasma Complete™
Myriad myRisk® Hereditary Cancer
NeXT Dx™ Test
NeoLAB® Solid Tumor Liquid Biopsy
Northstar Select™
NovoFocus™ PARPi CDx
OncoGuide™ NCC Oncopanel System
OncoPanel™ Assay
Oncomine Precision Assay
Oncomine Tumor Mutation Load Assay
OvaNext®
ProstateNext®
QVantageᵀᴹ
RenalNext™
SOPHiA DDM HRD Solution
SureSeq™ Pan-Myeloid Panel
Tempus xF+ Panel
Tempus xG+
TruSight Oncology Comprehensive
TruSight Tumor 170 Assay
TumorNext-HRD
VarMap™ Pan-Cancer NGS Panel
›
Associations
(13)
News
Trials
VERI cancer hierarchy
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CHEK2 mutation
Prostate Cancer
CHEK2 mutation
Prostate Cancer
olaparib
Sensitive: A2 - Guideline
olaparib
Sensitive
:
A2
olaparib
Sensitive: A2 - Guideline
olaparib
Sensitive
:
A2
CHEK2 mutation
Ovarian Cancer
CHEK2 mutation
Ovarian Cancer
olaparib
Sensitive: B - Late Trials
olaparib
Sensitive
:
B
olaparib
Sensitive: B - Late Trials
olaparib
Sensitive
:
B
CHEK2 mutation
HER2 Negative Breast Cancer
CHEK2 mutation
HER2 Negative Breast Cancer
durvalumab
Sensitive: C2 – Inclusion Criteria
durvalumab
Sensitive
:
C2
durvalumab
Sensitive: C2 – Inclusion Criteria
durvalumab
Sensitive
:
C2
CHEK2 mutation
Prostate Cancer
CHEK2 mutation
Prostate Cancer
rucaparib
Sensitive: C2 – Inclusion Criteria
rucaparib
Sensitive
:
C2
rucaparib
Sensitive: C2 – Inclusion Criteria
rucaparib
Sensitive
:
C2
CHEK2 mutation + ATM mutation + BRCA2 mutation
Non Small Cell Lung Cancer
CHEK2 mutation + ATM mutation + BRCA2 mutation
Non Small Cell Lung Cancer
cetuximab + avelumab
Sensitive: C3 – Early Trials
cetuximab + avelumab
Sensitive
:
C3
cetuximab + avelumab
Sensitive: C3 – Early Trials
cetuximab + avelumab
Sensitive
:
C3
CHEK2 mutation
HER2 Negative Breast Cancer
CHEK2 mutation
HER2 Negative Breast Cancer
talazoparib
Sensitive: C3 – Early Trials
talazoparib
Sensitive
:
C3
talazoparib
Sensitive: C3 – Early Trials
talazoparib
Sensitive
:
C3
BRCA2 mutation + CHEK2 mutation
Prostate Cancer
BRCA2 mutation + CHEK2 mutation
Prostate Cancer
GnRH stimulant
Resistant: C3 – Early Trials
GnRH stimulant
Resistant
:
C3
GnRH stimulant
Resistant: C3 – Early Trials
GnRH stimulant
Resistant
:
C3
CHEK2 mutation
Breast Cancer
CHEK2 mutation
Breast Cancer
CDK4 inhibitor + CDK6 inhibitor
Resistant: C3 – Early Trials
CDK4 inhibitor + CDK6 inhibitor
Resistant
:
C3
CDK4 inhibitor + CDK6 inhibitor
Resistant: C3 – Early Trials
CDK4 inhibitor + CDK6 inhibitor
Resistant
:
C3
CHEK2 mutation
Pancreatic Ductal Adenocarcinoma
CHEK2 mutation
Pancreatic Ductal Adenocarcinoma
irinotecan
Sensitive: C3 – Early Trials
irinotecan
Sensitive
:
C3
irinotecan
Sensitive: C3 – Early Trials
irinotecan
Sensitive
:
C3
CHEK2 mutation
Tongue Carcinoma
CHEK2 mutation
Tongue Carcinoma
ABT-888 + M6620
Sensitive: C4 – Case Studies
ABT-888 + M6620
Sensitive
:
C4
ABT-888 + M6620
Sensitive: C4 – Case Studies
ABT-888 + M6620
Sensitive
:
C4
BRCA2 mutation + CHEK2 mutation
Pancreatic Adenocarcinoma
BRCA2 mutation + CHEK2 mutation
Pancreatic Adenocarcinoma
Sensitive: C4 – Case Studies
Sensitive
:
C4
Sensitive: C4 – Case Studies
Sensitive
:
C4
CHEK2 mutation
Testicular Cancer
CHEK2 mutation
Testicular Cancer
talazoparib
Sensitive: C4 – Case Studies
talazoparib
Sensitive
:
C4
talazoparib
Sensitive: C4 – Case Studies
talazoparib
Sensitive
:
C4
CHEK2 mutation
Prostate Cancer
CHEK2 mutation
Prostate Cancer
pembrolizumab
Sensitive: C4 – Case Studies
pembrolizumab
Sensitive
:
C4
pembrolizumab
Sensitive: C4 – Case Studies
pembrolizumab
Sensitive
:
C4
^
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