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our Premium Content: News alerts, weekly reports and conference plannersTEST:AmoyDx® HANDLE HRR NGS Panel
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Company:
Amoy DiagnosticsType:
CE Marked
Related tests:
The AmoyDx® HANDLE HRR NGS Panel (Reversible Terminator Sequencing) is intended for qualitative detection of single nucleotide variants (SNVs) and insertions and deletions (Indels) variants in protein coding regions and intron/exon boundaries of 27 HRR genes (AR, ATM, ATR, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CDK12, CHEK1, CHEK2, ESR1, FANCA, FANCL, HDAC2, HOXB13, MRE11, NBN, PALB2, PPP2R2A, PTEN, RAD51B, RAD51C, RAD51D, RAD54L, STK11 and TP53), and SNVs/Indels variants in hotspot regions of 5 driver genes (BRAF, ERBB2, KRAS, NRAS and PIK3CA) using DNA isolated from peripheral whole blood samples, fresh-frozen tumor tissue or formalin-fixed paraffin embedded (FFPE) tumor tissue specimens. In addition, the kit also allows the detection of large rearrangements (LRs) of the BRCA1 and BRCA2 genes from blood-derived DNA.
The kit is intended to be used by trained professionals in a laboratory environment.
Gene:
AR (Androgen receptor), ATM (ATM serine/threonine kinase), ATR (Ataxia telangiectasia and Rad3-related protein), BARD1 (BRCA1 Associated RING Domain 1), BRAF (B-raf proto-oncogene), BRCA1 (Breast cancer 1, early onset)
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AR (Androgen receptor), ATM (ATM serine/threonine kinase), ATR (Ataxia telangiectasia and Rad3-related protein), BARD1 (BRCA1 Associated RING Domain 1), BRAF (B-raf proto-oncogene), BRCA1 (Breast cancer 1, early onset), BRCA2 (Breast cancer 2, early onset), BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1), CDH1 (Cadherin 1), CDK12 (Cyclin dependent kinase 12), CHEK1 (Checkpoint kinase 1), CHEK2 (Checkpoint kinase 2), ER (Estrogen receptor), FANCA (FA Complementation Group A), FANCL (FA Complementation Group L), HDAC2 (Histone deacetylase 2), HER-2 (Human epidermal growth factor receptor 2), HOXB13 (Homeobox B13), KRAS (KRAS proto-oncogene GTPase), MRE11A (MRE11 homolog, double strand break repair nuclease), NBN (Nibrin Nijmegen Breakage Syndrome 1 (Nibrin)), NRAS (Neuroblastoma RAS viral oncogene homolog), PALB2 (Partner and localizer of BRCA2), PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha), PPP2R2A (Protein Phosphatase 2, Regulatory Subunit B, Alpha), PTEN (Phosphatase and tensin homolog), RAD51B (RAD51 Paralog B), RAD51C (RAD51 paralog C), RAD51D (RAD51 paralog D), RAD54L (DNA Repair And Recombination Protein RAD54), STK11 (Serine/threonine kinase 11), TP53 (Tumor protein P53)
Method:
Next-Generation Sequencing (NGS)
