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    DRUG:

    ADG138

    i
    Other names: ADG138
    Associations

    News

    Trials
    Company:
    Adagene
    Drug class:
    HER2 inhibitor, CD3 agonist, T-cell stimulant
    Related drugs:
    Associations

    News

    Trials
    almost3years
    ADG138, a novel HER2×CD3 POWERbody™ integrating bispecific TCE with precision masking to control cytokine release syndrome and on-target off-tumor toxicity for single agent and combination therapies in HER2-expressing solid tumors (AACR 2022)
    These nonclinical studies demonstrated that ADG138, a novel double masked HER2×CD3 POWERbody TCE, exhibited an impressively high therapeutic index relative to its parental non-masked TCE in HER2 high and low expressing solid tumors. This provides strong support for advancing the ADG138 prodrug into clinical development for treating HER2-expressing solid tumors as a single agent and in combination with other immune stimulatory agents.
    Combination therapy
    |
    HER-2 (Human epidermal growth factor receptor 2)
    |
    HER-2 positive • HER-2 expression • HER-2-H
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    ADG138