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DRUG:

Epkinly (epcoritamab-bysp)

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Company:

AbbVie, Genmab

Drug class:

CD20 inhibitor, CD3 agonist

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No biomarker	Diffuse Large B Cell Lymphoma	No biomarker	Diffuse Large B Cell Lymphoma	epcoritamab-bysp Sensitive: A1 - Approval epcoritamab-bysp Sensitive : A1	epcoritamab-bysp Sensitive: A1 - Approval epcoritamab-bysp Sensitive : A1
No biomarker	Follicular Lymphoma	No biomarker	Follicular Lymphoma	epcoritamab-bysp Sensitive: A1 - Approval epcoritamab-bysp Sensitive : A1	epcoritamab-bysp Sensitive: A1 - Approval epcoritamab-bysp Sensitive : A1
No biomarker	Mediastinal B Cell Lymphoma	No biomarker	Mediastinal B Cell Lymphoma	epcoritamab-bysp Sensitive: A1 - Approval epcoritamab-bysp Sensitive : A1	epcoritamab-bysp Sensitive: A1 - Approval epcoritamab-bysp Sensitive : A1
CD20 positive	Diffuse Large B Cell Lymphoma	CD20 positive	Diffuse Large B Cell Lymphoma	epcoritamab-bysp Sensitive: C2 – Inclusion Criteria epcoritamab-bysp Sensitive : C2	epcoritamab-bysp Sensitive: C2 – Inclusion Criteria epcoritamab-bysp Sensitive : C2
CD20 positive	Follicular Lymphoma	CD20 positive	Follicular Lymphoma	epcoritamab-bysp Sensitive: C2 – Inclusion Criteria epcoritamab-bysp Sensitive : C2	epcoritamab-bysp Sensitive: C2 – Inclusion Criteria epcoritamab-bysp Sensitive : C2
CD20 positive	Mantle Cell Lymphoma	CD20 positive	Mantle Cell Lymphoma	epcoritamab-bysp Sensitive: C3 – Early Trials epcoritamab-bysp Sensitive : C3	epcoritamab-bysp Sensitive: C3 – Early Trials epcoritamab-bysp Sensitive : C3
CD20 positive	Follicular Lymphoma	CD20 positive	Follicular Lymphoma	rituximab + lenalidomide + epcoritamab-bysp Sensitive: C3 – Early Trials rituximab + lenalidomide + epcoritamab-bysp Sensitive : C3	rituximab + lenalidomide + epcoritamab-bysp Sensitive: C3 – Early Trials rituximab + lenalidomide + epcoritamab-bysp Sensitive : C3
TP53 mutation + Chr del(17p)	Chronic Lymphocytic Leukemia	TP53 mutation + Chr del(17p)	Chronic Lymphocytic Leukemia	epcoritamab-bysp Sensitive: C3 – Early Trials epcoritamab-bysp Sensitive : C3	epcoritamab-bysp Sensitive: C3 – Early Trials epcoritamab-bysp Sensitive : C3
Chr del(17p)	Chronic Lymphocytic Leukemia	Chr del(17p)	Chronic Lymphocytic Leukemia	epcoritamab-bysp Sensitive: C3 – Early Trials epcoritamab-bysp Sensitive : C3	epcoritamab-bysp Sensitive: C3 – Early Trials epcoritamab-bysp Sensitive : C3
TP53 mutation	Chronic Lymphocytic Leukemia	TP53 mutation	Chronic Lymphocytic Leukemia	epcoritamab-bysp Sensitive: C3 – Early Trials epcoritamab-bysp Sensitive : C3	epcoritamab-bysp Sensitive: C3 – Early Trials epcoritamab-bysp Sensitive : C3
CD20 expression	Non-Hodgkin’s Lymphoma	CD20 expression	Non-Hodgkin’s Lymphoma	lenalidomide + epcoritamab-bysp Sensitive: D – Preclinical lenalidomide + epcoritamab-bysp Sensitive : D	lenalidomide + epcoritamab-bysp Sensitive: D – Preclinical lenalidomide + epcoritamab-bysp Sensitive : D