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DRUG:

zenocutuzumab (MCLA-128)

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Company:

Merus

Drug class:

HER2 inhibitor, HER3 inhibitor

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NRG1 fusion	Solid Tumor	NRG1 fusion	Solid Tumor	MCLA-128 Sensitive: B - Late Trials MCLA-128 Sensitive : B	MCLA-128 Sensitive: B - Late Trials MCLA-128 Sensitive : B
NRG1 fusion	Pancreatic Cancer	NRG1 fusion	Pancreatic Cancer	MCLA-128 Sensitive: B - Late Trials MCLA-128 Sensitive : B	MCLA-128 Sensitive: B - Late Trials MCLA-128 Sensitive : B
NRG1 fusion	Non Small Cell Lung Cancer	NRG1 fusion	Non Small Cell Lung Cancer	MCLA-128 Sensitive: B - Late Trials MCLA-128 Sensitive : B	MCLA-128 Sensitive: B - Late Trials MCLA-128 Sensitive : B
NRG1 fusion	Pancreatic Ductal Adenocarcinoma	NRG1 fusion	Pancreatic Ductal Adenocarcinoma	MCLA-128 Sensitive: B - Late Trials MCLA-128 Sensitive : B	MCLA-128 Sensitive: B - Late Trials MCLA-128 Sensitive : B
NRG1 fusion	Pancreatic Cancer	NRG1 fusion	Pancreatic Cancer	MCLA-128 Sensitive: C2 – Inclusion Criteria MCLA-128 Sensitive : C2	MCLA-128 Sensitive: C2 – Inclusion Criteria MCLA-128 Sensitive : C2
NRG1 fusion	Cholangiocarcinoma	NRG1 fusion	Cholangiocarcinoma	MCLA-128 Sensitive: C2 – Inclusion Criteria MCLA-128 Sensitive : C2	MCLA-128 Sensitive: C2 – Inclusion Criteria MCLA-128 Sensitive : C2
NRG1 fusion	Breast Cancer	NRG1 fusion	Breast Cancer	MCLA-128 Sensitive: C2 – Inclusion Criteria MCLA-128 Sensitive : C2	MCLA-128 Sensitive: C2 – Inclusion Criteria MCLA-128 Sensitive : C2
HER-2 positive	Gastroesophageal Junction Adenocarcinoma	HER-2 positive	Gastroesophageal Junction Adenocarcinoma	MCLA-128 Sensitive: C3 – Early Trials MCLA-128 Sensitive : C3	MCLA-128 Sensitive: C3 – Early Trials MCLA-128 Sensitive : C3
HER-2 positive	Gastric Cancer	HER-2 positive	Gastric Cancer	MCLA-128 Sensitive: C3 – Early Trials MCLA-128 Sensitive : C3	MCLA-128 Sensitive: C3 – Early Trials MCLA-128 Sensitive : C3
ATP1B1-NRG1 fusion	Pancreatic Cancer	ATP1B1-NRG1 fusion	Pancreatic Cancer	MCLA-128 Sensitive: C3 – Early Trials MCLA-128 Sensitive : C3	MCLA-128 Sensitive: C3 – Early Trials MCLA-128 Sensitive : C3
HER-2 overexpression	HER2 Positive Breast Cancer	HER-2 overexpression	HER2 Positive Breast Cancer	trastuzumab + MCLA-128 Sensitive: C3 – Early Trials trastuzumab + MCLA-128 Sensitive : C3	trastuzumab + MCLA-128 Sensitive: C3 – Early Trials trastuzumab + MCLA-128 Sensitive : C3
CD74-NRG1 fusion	Non Small Cell Lung Cancer	CD74-NRG1 fusion	Non Small Cell Lung Cancer	MCLA-128 Sensitive: C4 – Case Studies MCLA-128 Sensitive : C4	MCLA-128 Sensitive: C4 – Case Studies MCLA-128 Sensitive : C4
SLC3A2-NRG1 fusion	Estrogen Receptor Positive Breast Cancer	SLC3A2-NRG1 fusion	Estrogen Receptor Positive Breast Cancer	MCLA-128 Sensitive: C4 – Case Studies MCLA-128 Sensitive : C4	MCLA-128 Sensitive: C4 – Case Studies MCLA-128 Sensitive : C4
CLU-NRG1 fusion	Ovarian Cancer	CLU-NRG1 fusion	Ovarian Cancer	MCLA-128 Sensitive: D – Preclinical MCLA-128 Sensitive : D	MCLA-128 Sensitive: D – Preclinical MCLA-128 Sensitive : D
SLC3A2-NRG1 fusion	Ovarian Cancer	SLC3A2-NRG1 fusion	Ovarian Cancer	MCLA-128 Sensitive: D – Preclinical MCLA-128 Sensitive : D	MCLA-128 Sensitive: D – Preclinical MCLA-128 Sensitive : D
HER-2 amplification	Solid Tumor	HER-2 amplification	Solid Tumor	MCLA-128 Sensitive: D – Preclinical MCLA-128 Sensitive : D	MCLA-128 Sensitive: D – Preclinical MCLA-128 Sensitive : D