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DRUG:

Margenza (margetuximab)

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News alerts, weekly reports and conference planners

Company:

GC Biopharma, MacroGenics, ZAI Lab

Drug class:

HER2 inhibitor

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HER-2 positive	HER2 Positive Breast Cancer	HER-2 positive	HER2 Positive Breast Cancer	margetuximab Sensitive: A1 - Approval margetuximab Sensitive : A1	margetuximab Sensitive: A1 - Approval margetuximab Sensitive : A1
FCGR3A 158F	HER2 Positive Breast Cancer	FCGR3A 158F	HER2 Positive Breast Cancer	margetuximab Sensitive: B - Late Trials margetuximab Sensitive : B	margetuximab Sensitive: B - Late Trials margetuximab Sensitive : B
HER-2 positive	HER2 Positive Breast Cancer	HER-2 positive	HER2 Positive Breast Cancer	margetuximab + MGD013 Sensitive: C2 – Inclusion Criteria margetuximab + MGD013 Sensitive : C2	margetuximab + MGD013 Sensitive: C2 – Inclusion Criteria margetuximab + MGD013 Sensitive : C2
HER-2 positive	Gastric Adenocarcinoma	HER-2 positive	Gastric Adenocarcinoma	pembrolizumab + margetuximab Sensitive: C2 – Inclusion Criteria pembrolizumab + margetuximab Sensitive : C2	pembrolizumab + margetuximab Sensitive: C2 – Inclusion Criteria pembrolizumab + margetuximab Sensitive : C2
HER-2 mutation	Gastroesophageal Junction Adenocarcinoma	HER-2 mutation	Gastroesophageal Junction Adenocarcinoma	pembrolizumab + margetuximab Sensitive: C2 – Inclusion Criteria pembrolizumab + margetuximab Sensitive : C2	pembrolizumab + margetuximab Sensitive: C2 – Inclusion Criteria pembrolizumab + margetuximab Sensitive : C2
HER-2 amplification + PD-L1 expression	Gastric Cancer	HER-2 amplification + PD-L1 expression	Gastric Cancer	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3
PD-L1 expression	Gastric Adenocarcinoma	PD-L1 expression	Gastric Adenocarcinoma	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3
HER-2 expression	Gastrointestinal Cancer	HER-2 expression	Gastrointestinal Cancer	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3
PD-L1 expression + HER-2 overexpression	Gastroesophageal Junction Adenocarcinoma	PD-L1 expression + HER-2 overexpression	Gastroesophageal Junction Adenocarcinoma	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3
PD-L1 expression + HER-2 overexpression	Gastric Cancer	PD-L1 expression + HER-2 overexpression	Gastric Cancer	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3
PD-L1 expression	Gastroesophageal Junction Adenocarcinoma	PD-L1 expression	Gastroesophageal Junction Adenocarcinoma	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3
HER-2 amplification + PD-L1 expression	Gastroesophageal Junction Adenocarcinoma	HER-2 amplification + PD-L1 expression	Gastroesophageal Junction Adenocarcinoma	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3
HER-2 amplification	Gastroesophageal Junction Adenocarcinoma	HER-2 amplification	Gastroesophageal Junction Adenocarcinoma	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3
HER-2 amplification	Gastric Cancer	HER-2 amplification	Gastric Cancer	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3
HER-2 positive	Colorectal Cancer	HER-2 positive	Colorectal Cancer	margetuximab + MGD013 Sensitive: C3 – Early Trials margetuximab + MGD013 Sensitive : C3	margetuximab + MGD013 Sensitive: C3 – Early Trials margetuximab + MGD013 Sensitive : C3
HER-2 positive	Gastroesophageal Cancer	HER-2 positive	Gastroesophageal Cancer	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3	pembrolizumab + margetuximab Sensitive: C3 – Early Trials pembrolizumab + margetuximab Sensitive : C3
HER-2 positive + PD-L1 expression	Gastroesophageal Cancer	HER-2 positive + PD-L1 expression	Gastroesophageal Cancer	margetuximab + retifanlimab-dlwr Sensitive: C3 – Early Trials margetuximab + retifanlimab-dlwr Sensitive : C3	margetuximab + retifanlimab-dlwr Sensitive: C3 – Early Trials margetuximab + retifanlimab-dlwr Sensitive : C3
HR negative	HER2 Positive Breast Cancer	HR negative	HER2 Positive Breast Cancer	margetuximab Sensitive: C4 – Case Studies margetuximab Sensitive : C4	margetuximab Sensitive: C4 – Case Studies margetuximab Sensitive : C4