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DRUG:

Margenza (margetuximab-cmkb)

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Company:

GC Biopharma, MacroGenics, TerSera Therap, ZAI Lab

Drug class:

HER2 inhibitor

Related drugs:

trastuzumab biosimilar (0)

trastuzumab (407)

lapatinib (107)

neratinib (102)

trastuzumab-pkrb (24)

poziotinib (17)

zenocutuzumab-zbco (16)

mobocertinib (12)

trastuzumab-dttb (11)

zanidatamab-hrii (11)

trastuzumab-strf (9)

trastuzumab-anns (9)

trastuzumab-dkst (9)

trastuzumab-qyyp (9)

Undisclosed allogeneic Vγ9Vδ2 HER2-TAC T (4)

pertuzumab/trastuzumab/hyaluronidase-zzxf (3)

trastuzumab/hyaluronidase-oysk (2)

JBJ-08–178–01 (2)

Hercease (trastuzumab biosimilar) (1)

BAY 2927088 (1)

HERtiCAD (trastuzumab biosimilar) (1)

Hervelous (trastuzumab biosimilar) (1)

EG12014 (trastuzumab biosimilar) (1)

TX05 (trastuzumab biosimilar) (1)

ALT02 (trastuzumab biosimilar) (0)

trastuzumab biosimilar (AP062) (0)

DA 3111 (trastuzumab biosimilar) (0)

HER-2/neu peptide vaccine (0)

HER2 t-haNK (0)

HLX11 (pertuzumab biosimilar) (0)

Hervycta (trastuzumab biosimilar) (0)

JNJ-26483327 (0)

MVA-BN-HER2 (0)

NeuCeptin (trastuzumab biosimilar) (0)

nelipepimut-S (0)

lapuleucel-T (0)

ertumaxomab (0)

trastuzumab biosimilar (SIBP-01) (0)

TAC100-HER2 (0)

glycooptimized trastuzumab-GEX (0)

TrastuRel (trastuzumab biosimilar) (0)

Undisclosed HER2Bi-armed ATC (0)

trastuzumab biosimilar (0)

trastuzumab biosimilar (0)

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HER-2 positive	HER2 Positive Breast Cancer	HER-2 positive	HER2 Positive Breast Cancer	margetuximab-cmkb Sensitive: A1 - Approval margetuximab-cmkb Sensitive : A1	margetuximab-cmkb Sensitive: A1 - Approval margetuximab-cmkb Sensitive : A1
FCGR3A 158F	HER2 Positive Breast Cancer	FCGR3A 158F	HER2 Positive Breast Cancer	margetuximab-cmkb Sensitive: B - Late Trials margetuximab-cmkb Sensitive : B	margetuximab-cmkb Sensitive: B - Late Trials margetuximab-cmkb Sensitive : B
HER-2 positive	HER2 Positive Breast Cancer	HER-2 positive	HER2 Positive Breast Cancer	margetuximab-cmkb + MGD013 Sensitive: C2 – Inclusion Criteria margetuximab-cmkb + MGD013 Sensitive : C2	margetuximab-cmkb + MGD013 Sensitive: C2 – Inclusion Criteria margetuximab-cmkb + MGD013 Sensitive : C2
HER-2 positive	Gastric Adenocarcinoma	HER-2 positive	Gastric Adenocarcinoma	pembrolizumab + margetuximab-cmkb Sensitive: C2 – Inclusion Criteria pembrolizumab + margetuximab-cmkb Sensitive : C2	pembrolizumab + margetuximab-cmkb Sensitive: C2 – Inclusion Criteria pembrolizumab + margetuximab-cmkb Sensitive : C2
HER-2 mutation	Gastroesophageal Junction Adenocarcinoma	HER-2 mutation	Gastroesophageal Junction Adenocarcinoma	pembrolizumab + margetuximab-cmkb Sensitive: C2 – Inclusion Criteria pembrolizumab + margetuximab-cmkb Sensitive : C2	pembrolizumab + margetuximab-cmkb Sensitive: C2 – Inclusion Criteria pembrolizumab + margetuximab-cmkb Sensitive : C2
HER-2 amplification + PD-L1 expression	Gastric Cancer	HER-2 amplification + PD-L1 expression	Gastric Cancer	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3
PD-L1 expression	Gastric Adenocarcinoma	PD-L1 expression	Gastric Adenocarcinoma	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3
HER-2 expression	Gastrointestinal Cancer	HER-2 expression	Gastrointestinal Cancer	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3
PD-L1 expression + HER-2 overexpression	Gastroesophageal Junction Adenocarcinoma	PD-L1 expression + HER-2 overexpression	Gastroesophageal Junction Adenocarcinoma	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3
PD-L1 expression + HER-2 overexpression	Gastric Cancer	PD-L1 expression + HER-2 overexpression	Gastric Cancer	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3
PD-L1 expression	Gastroesophageal Junction Adenocarcinoma	PD-L1 expression	Gastroesophageal Junction Adenocarcinoma	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3
HER-2 amplification + PD-L1 expression	Gastroesophageal Junction Adenocarcinoma	HER-2 amplification + PD-L1 expression	Gastroesophageal Junction Adenocarcinoma	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3
HER-2 amplification	Gastroesophageal Junction Adenocarcinoma	HER-2 amplification	Gastroesophageal Junction Adenocarcinoma	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3
HER-2 amplification	Gastric Cancer	HER-2 amplification	Gastric Cancer	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3
HER-2 positive	Colorectal Cancer	HER-2 positive	Colorectal Cancer	margetuximab-cmkb + MGD013 Sensitive: C3 – Early Trials margetuximab-cmkb + MGD013 Sensitive : C3	margetuximab-cmkb + MGD013 Sensitive: C3 – Early Trials margetuximab-cmkb + MGD013 Sensitive : C3
HER-2 positive	Gastroesophageal Cancer	HER-2 positive	Gastroesophageal Cancer	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3	pembrolizumab + margetuximab-cmkb Sensitive: C3 – Early Trials pembrolizumab + margetuximab-cmkb Sensitive : C3
HER-2 positive + PD-L1 expression	Gastroesophageal Cancer	HER-2 positive + PD-L1 expression	Gastroesophageal Cancer	margetuximab-cmkb + retifanlimab-dlwr Sensitive: C3 – Early Trials margetuximab-cmkb + retifanlimab-dlwr Sensitive : C3	margetuximab-cmkb + retifanlimab-dlwr Sensitive: C3 – Early Trials margetuximab-cmkb + retifanlimab-dlwr Sensitive : C3
HR negative	HER2 Positive Breast Cancer	HR negative	HER2 Positive Breast Cancer	margetuximab-cmkb Sensitive: C4 – Case Studies margetuximab-cmkb Sensitive : C4	margetuximab-cmkb Sensitive: C4 – Case Studies margetuximab-cmkb Sensitive : C4