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DRUG:

Exkivity (mobocertinib)

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News alerts, weekly reports and conference planners

Company:

Takeda

Drug class:

EGFR inhibitor, HER2 inhibitor

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EGFR exon 20 insertion	Non Small Cell Lung Cancer	EGFR exon 20 insertion	Non Small Cell Lung Cancer	mobocertinib Sensitive: A1 - Approval mobocertinib Sensitive : A1	mobocertinib Sensitive: A1 - Approval mobocertinib Sensitive : A1
HER-2 exon 20 insertion	Non Small Cell Lung Cancer	HER-2 exon 20 insertion	Non Small Cell Lung Cancer	mobocertinib Sensitive: C2 – Inclusion Criteria mobocertinib Sensitive : C2	mobocertinib Sensitive: C2 – Inclusion Criteria mobocertinib Sensitive : C2
EGFR C797S + EGFR exon 20 insertion	Non Small Cell Lung Cancer	EGFR C797S + EGFR exon 20 insertion	Non Small Cell Lung Cancer	mobocertinib Sensitive: C3 – Early Trials mobocertinib Sensitive : C3	mobocertinib Sensitive: C3 – Early Trials mobocertinib Sensitive : C3
EGFR exon 20 insertion	Non Small Cell Lung Cancer	EGFR exon 20 insertion	Non Small Cell Lung Cancer	bevacizumab + mobocertinib Sensitive: C4 – Case Studies bevacizumab + mobocertinib Sensitive : C4	bevacizumab + mobocertinib Sensitive: C4 – Case Studies bevacizumab + mobocertinib Sensitive : C4
HER-2 exon 20G776>VC insertion	Non Small Cell Lung Cancer	HER-2 exon 20G776>VC insertion	Non Small Cell Lung Cancer	mobocertinib Sensitive: D – Preclinical mobocertinib Sensitive : D	mobocertinib Sensitive: D – Preclinical mobocertinib Sensitive : D
HER-2 A775_G776insYVMA	Non Small Cell Lung Cancer	HER-2 A775_G776insYVMA	Non Small Cell Lung Cancer	mobocertinib Sensitive: D – Preclinical mobocertinib Sensitive : D	mobocertinib Sensitive: D – Preclinical mobocertinib Sensitive : D
HER-2 exon 20 YVMA insertion	Lung Adenocarcinoma	HER-2 exon 20 YVMA insertion	Lung Adenocarcinoma	ado-trastuzumab emtansine + mobocertinib Resistant: D – Preclinical ado-trastuzumab emtansine + mobocertinib Resistant : D	ado-trastuzumab emtansine + mobocertinib Resistant: D – Preclinical ado-trastuzumab emtansine + mobocertinib Resistant : D
HER-2 exon 20 YVMA insertion	Lung Adenocarcinoma	HER-2 exon 20 YVMA insertion	Lung Adenocarcinoma	mobocertinib Resistant: D – Preclinical mobocertinib Resistant : D	mobocertinib Resistant: D – Preclinical mobocertinib Resistant : D
HER-2 exon 20G776>VC insertion	Lung Adenocarcinoma	HER-2 exon 20G776>VC insertion	Lung Adenocarcinoma	mobocertinib Sensitive: D – Preclinical mobocertinib Sensitive : D	mobocertinib Sensitive: D – Preclinical mobocertinib Sensitive : D
EGFR S768dupSVD	Non Small Cell Lung Cancer	EGFR S768dupSVD	Non Small Cell Lung Cancer	amivantamab-vmjw + mobocertinib Sensitive: D – Preclinical amivantamab-vmjw + mobocertinib Sensitive : D	amivantamab-vmjw + mobocertinib Sensitive: D – Preclinical amivantamab-vmjw + mobocertinib Sensitive : D
EGFR A767dupASV	Non Small Cell Lung Cancer	EGFR A767dupASV	Non Small Cell Lung Cancer	amivantamab-vmjw + mobocertinib Sensitive: D – Preclinical amivantamab-vmjw + mobocertinib Sensitive : D	amivantamab-vmjw + mobocertinib Sensitive: D – Preclinical amivantamab-vmjw + mobocertinib Sensitive : D
HER-2 T862A + HER-2 L755S	Breast Cancer	HER-2 T862A + HER-2 L755S	Breast Cancer	mobocertinib Sensitive: D – Preclinical mobocertinib Sensitive : D	mobocertinib Sensitive: D – Preclinical mobocertinib Sensitive : D