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DRUG:
Gilotrif (afatinib)
i
Other names:
BIBW 2992, BIBW 2992 MA2, BIBW-2992, BIBW2992
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Associations
(227)
News
Trials
Company:
Boehringer Ingelheim
Drug class:
EGFR inhibitor, HER2 inhibitor, HER4 inhibitor
Related drugs:
‹
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lapatinib (107)
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brigatinib (50)
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CUDC-101 (0)
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trastuzumab biosimilar (SIBP-01) (0)
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CUDC-101 (0)
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DF9001 (0)
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STI-001 (cetuximab biosimilar) (0)
FHND9041 (0)
HLX35 (0)
HS-10375 (0)
antroquinonol (0)
zalutumumab (0)
IAE0972 (0)
IBI-334 (0)
JANX008 (0)
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JS111 (0)
MM-151 (0)
MP412 (0)
MTX-211 (0)
PF-08046052 (0)
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QLH11811 (0)
rindopepimut (0)
SR13668 (0)
SYN004 (0)
Sym013 (0)
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TAK-285 (0)
TAS-121 (0)
TAVO412 (0)
THE-349 (0)
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TQB3804 (0)
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XZP-5809 (0)
simotinib (0)
ZN-e4 (0)
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SY101 (0)
Ami-LC (0)
TY-9591 (0)
EMB-01 (0)
cetuximab biosimilar (0)
cipatinib (0)
ABT-806 (0)
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RO5083945 (0)
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EMD 72000 (0)
PF-06747775 (0)
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AZD8931 (0)
trastuzumab (407)
tucatinib (39)
trastuzumab-pkrb (24)
margetuximab-cmkb (18)
poziotinib (17)
MCLA-128 (16)
KN026 (14)
trastuzumab-dttb (11)
ZW25 (10)
trastuzumab-strf (9)
trastuzumab-anns (9)
trastuzumab-dkst (9)
trastuzumab-qyyp (9)
LZM-005 (8)
PRS-343 (8)
D3L-001 (7)
inetetamab (6)
MT-5111 (4)
Undisclosed allogeneic Vγ9Vδ2 HER2-TAC T (4)
pertuzumab/trastuzumab/hyaluronidase-zzxf (3)
trastuzumab-IFN-β mutein (3)
AST-301 (2)
CT-0508 (2)
DF1001 (2)
ER121 (2)
Her-VAXX (2)
trastuzumab/hyaluronidase-oysk (2)
JBJ-08–178–01 (2)
VIR-5818 (2)
BDC-1001 (2)
ABL105 (1)
ACE1702 (1)
Hercease (trastuzumab biosimilar) (1)
BAY2701439 (1)
DZD1516 (1)
GCC2003 (1)
HERtiCAD (trastuzumab biosimilar) (1)
Hervelous (trastuzumab biosimilar) (1)
EG12014 (trastuzumab biosimilar) (1)
IAH0968 (1)
IMM2902 (1)
MP0274 (1)
RG6596 (1)
SAR443216 (1)
(1)
TX05 (trastuzumab biosimilar) (1)
VRN101099 (1)
ADG138 (0)
ALT02 (trastuzumab biosimilar) (0)
trastuzumab biosimilar (AP062) (0)
B-Vaxx (0)
BAT1006 (0)
BAY2701438 (0)
CAM-H2 (0)
CAT-179 (0)
DA 3111 (trastuzumab biosimilar) (0)
(0)
ELVN-002 (0)
ES2B-C001 (0)
ETBX-021 (0)
(0)
GB235 (0)
HER-2/neu peptide vaccine (0)
HER2 t-haNK (0)
HF158K1 (0)
HLX11 (pertuzumab biosimilar) (0)
Hervycta (trastuzumab biosimilar) (0)
ISB 1302 (0)
OST-HER2 (0)
MBS301 (0)
MM 111 (0)
MVA-BN-HER2 (0)
NVL-330 (0)
NeuCeptin (trastuzumab biosimilar) (0)
nelipepimut-S (0)
lapuleucel-T (0)
OS47701 (0)
QP34563457 (0)
ertumaxomab (0)
trastuzumab biosimilar (SIBP-01) (0)
SPH5030 (0)
SSGJ-705 (0)
(0)
TAC100-HER2 (0)
TAS0728 (0)
TPIV100 (0)
TQB2930 (0)
glycooptimized trastuzumab-GEX (0)
TrastuRel (trastuzumab biosimilar) (0)
Undisclosed HER2Bi-armed ATC (0)
VM 206 (0)
YH42946 (0)
dHER2+AS15 (0)
IBI315 (0)
RG6194 (0)
trastuzumab biosimilar (0)
trastuzumab biosimilar (0)
›
Associations
(227)
News
Trials
VERI cancer hierarchy
Reset Filters
EGFR exon 19 deletion
Non Small Cell Lung Cancer
EGFR exon 19 deletion
Non Small Cell Lung Cancer
afatinib
Sensitive: A1 - Approval
afatinib
Sensitive
:
A1
afatinib
Sensitive: A1 - Approval
afatinib
Sensitive
:
A1
EGFR L858R
Non Small Cell Lung Cancer
EGFR L858R
Non Small Cell Lung Cancer
afatinib
Sensitive: A1 - Approval
afatinib
Sensitive
:
A1
afatinib
Sensitive: A1 - Approval
afatinib
Sensitive
:
A1
EGFR mutation
Non Small Cell Lung Cancer
EGFR mutation
Non Small Cell Lung Cancer
afatinib
Sensitive: A1 - Approval
afatinib
Sensitive
:
A1
afatinib
Sensitive: A1 - Approval
afatinib
Sensitive
:
A1
No biomarker
Non Small Cell Lung Cancer
No biomarker
Non Small Cell Lung Cancer
afatinib
Sensitive: A1 - Approval
afatinib
Sensitive
:
A1
afatinib
Sensitive: A1 - Approval
afatinib
Sensitive
:
A1
No biomarker
Lung Non-Small Cell Squamous Cancer
No biomarker
Lung Non-Small Cell Squamous Cancer
afatinib
Sensitive: A1 - Approval
afatinib
Sensitive
:
A1
afatinib
Sensitive: A1 - Approval
afatinib
Sensitive
:
A1
No biomarker
Oral Cancer
No biomarker
Oral Cancer
afatinib
Sensitive: A2 - Guideline
afatinib
Sensitive
:
A2
afatinib
Sensitive: A2 - Guideline
afatinib
Sensitive
:
A2
No biomarker
Oropharyngeal Cancer
No biomarker
Oropharyngeal Cancer
afatinib
Sensitive: A2 - Guideline
afatinib
Sensitive
:
A2
afatinib
Sensitive: A2 - Guideline
afatinib
Sensitive
:
A2
EGFR S768I
Non Small Cell Lung Cancer
EGFR S768I
Non Small Cell Lung Cancer
afatinib
Sensitive: A2 - Guideline
afatinib
Sensitive
:
A2
afatinib
Sensitive: A2 - Guideline
afatinib
Sensitive
:
A2
EGFR G719X
Non Small Cell Lung Cancer
EGFR G719X
Non Small Cell Lung Cancer
afatinib
Sensitive: A2 - Guideline
afatinib
Sensitive
:
A2
afatinib
Sensitive: A2 - Guideline
afatinib
Sensitive
:
A2
EGFR L861Q
Non Small Cell Lung Cancer
EGFR L861Q
Non Small Cell Lung Cancer
afatinib
Sensitive: A2 - Guideline
afatinib
Sensitive
:
A2
afatinib
Sensitive: A2 - Guideline
afatinib
Sensitive
:
A2
HER-2 mutation
Non Small Cell Lung Cancer
HER-2 mutation
Non Small Cell Lung Cancer
afatinib
Resistant: A2 - Guideline
afatinib
Resistant
:
A2
afatinib
Resistant: A2 - Guideline
afatinib
Resistant
:
A2
EGFR mutation
Lung Non-Squamous Non-Small Cell Cancer
EGFR mutation
Lung Non-Squamous Non-Small Cell Cancer
afatinib
Sensitive: A2 - Guideline
afatinib
Sensitive
:
A2
afatinib
Sensitive: A2 - Guideline
afatinib
Sensitive
:
A2
EGFR exon 20 insertion
Non Small Cell Lung Cancer
EGFR exon 20 insertion
Non Small Cell Lung Cancer
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
EGFR T790M
Non Small Cell Lung Cancer
EGFR T790M
Non Small Cell Lung Cancer
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
EGFR mutation
Lung Adenocarcinoma
EGFR mutation
Lung Adenocarcinoma
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
EGFR L858R + EGFR T790M
Non Small Cell Lung Cancer
osimertinib + afatinib
Sensitive: B - Late Trials
osimertinib + afatinib
Sensitive
:
B
osimertinib + afatinib
Sensitive: B - Late Trials
osimertinib + afatinib
Sensitive
:
B
EGFR exon 19 deletion
Lung Adenocarcinoma
EGFR exon 19 deletion
Lung Adenocarcinoma
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
EGFR amplification
Squamous Cell Carcinoma of Head and Neck
EGFR amplification
Squamous Cell Carcinoma of Head and Neck
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
ERBB3-L
Squamous Cell Carcinoma of Head and Neck
ERBB3-L
Squamous Cell Carcinoma of Head and Neck
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
CDKN2A negative
Squamous Cell Carcinoma of Head and Neck
CDKN2A negative
Squamous Cell Carcinoma of Head and Neck
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
PTEN overexpression
Squamous Cell Carcinoma of Head and Neck
PTEN overexpression
Squamous Cell Carcinoma of Head and Neck
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
ERBB4 G668V
Lung Non-Small Cell Squamous Cancer
ERBB4 G668V
Lung Non-Small Cell Squamous Cancer
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
EGFR R1052K
Lung Non-Small Cell Squamous Cancer
EGFR R1052K
Lung Non-Small Cell Squamous Cancer
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
HER-2 E395K
Lung Non-Small Cell Squamous Cancer
HER-2 E395K
Lung Non-Small Cell Squamous Cancer
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
HER-2 Q57R
Lung Non-Small Cell Squamous Cancer
HER-2 Q57R
Lung Non-Small Cell Squamous Cancer
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
EGFR L858R
Lung Adenocarcinoma
EGFR L858R
Lung Adenocarcinoma
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
afatinib
Sensitive: B - Late Trials
afatinib
Sensitive
:
B
EGFR mutation
Esophageal Squamous Cell Carcinoma
EGFR mutation
Esophageal Squamous Cell Carcinoma
afatinib
Sensitive: C1 - Off-label
afatinib
Sensitive
:
C1
afatinib
Sensitive: C1 - Off-label
afatinib
Sensitive
:
C1
EGFR mutation
Gastric Cancer
EGFR mutation
Gastric Cancer
afatinib
Sensitive: C1 - Off-label
afatinib
Sensitive
:
C1
afatinib
Sensitive: C1 - Off-label
afatinib
Sensitive
:
C1
EGFR exon 20 insertion
Non Small Cell Lung Cancer
EGFR exon 20 insertion
Non Small Cell Lung Cancer
cetuximab + afatinib
Sensitive: C2 – Inclusion Criteria
cetuximab + afatinib
Sensitive
:
C2
cetuximab + afatinib
Sensitive: C2 – Inclusion Criteria
cetuximab + afatinib
Sensitive
:
C2
EGFR mutation
Lung Adenocarcinoma
EGFR mutation
Lung Adenocarcinoma
bevacizumab + afatinib
Sensitive: C2 – Inclusion Criteria
bevacizumab + afatinib
Sensitive
:
C2
bevacizumab + afatinib
Sensitive: C2 – Inclusion Criteria
bevacizumab + afatinib
Sensitive
:
C2
KRAS mutation
Non Small Cell Lung Cancer
KRAS mutation
Non Small Cell Lung Cancer
afatinib + selumetinib
Sensitive: C2 – Inclusion Criteria
afatinib + selumetinib
Sensitive
:
C2
afatinib + selumetinib
Sensitive: C2 – Inclusion Criteria
afatinib + selumetinib
Sensitive
:
C2
HER-2 amplification
Non Small Cell Lung Cancer
HER-2 amplification
Non Small Cell Lung Cancer
afatinib
Sensitive: C2 – Inclusion Criteria
afatinib
Sensitive
:
C2
afatinib
Sensitive: C2 – Inclusion Criteria
afatinib
Sensitive
:
C2
^
^
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