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BIOMARKER:

NRAS mutation + BRAF mutation

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Entrez ID:

Related biomarkers:

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BRAF V600E (255)

BRAF mutation (129)

NRAS mutation (125)

BRAF V600 (106)

BRAF V600K (25)

BRAF wild-type (25)

RAS wild-type (17)

NRAS wild-type (10)

RAS wild-type + BRAF wild-type (7)

BRAF V600E + RNF43 mutation (6)

EGFR mutation + BRAF V600E (6)

BRAF V600E + PIK3CA mutation (4)

BRAF T1799A (3)

BRAF V600E + TERT mutation (3)

BRAF delNVTAP (3)

NRAS Q61K + BRAF V600E (3)

TERT mutation + BRAF V600E (3)

FLT3 mutation + NRAS mutation (3)

NRAS exon 2 mutation (3)

NRAS exon 4 mutation (3)

BRAF V600E + MAP2K1 I111S (2)

BRAF mutation + MEK1 P124L (2)

BRAF mutation + NF1 mutation (2)

BRAF rearrangement (2)

EGFR mutation + BRAF V600 (2)

IDH1 wild-type + BRAF mutation (2)

KRAS G13D + BRAF mutation (2)

MYD88 L265P + BRAF V600E (2)

NRAS G12C + BRAF mutation (2)

EGFR mutation + NRAS Q61K (2)

NRAS exon 3 mutation (2)

AKT1 E17K + BRAF V600 (1)

BRAF 486_490 del (1)

BRAF G466E + NF1 Y2285fs*5 + NF1 Y2640fs*3 + TP53 D281Y (1)

BRAF G466V + KIT K509Q (1)

BRAF N486-P490del + TP53 V157G (1)

BRAF V600 wild-type (1)

BRAF V600DK601del (1)

BRAF V600E + BRAF G469A + BRAF G469V (1)

BRAF V600E + BRAF K601_W604del (1)

BRAF V600E + BRAF L514V (1)

BRAF V600E + BRAF V600K (1)

BRAF V600E + KRAS G12R (1)

BRAF V600E + MSI-H/dMMR (1)

BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L (1)

BRAF V600_K601delinsE (1)

BRAF mutation + EGFR mutation (1)

BRAF mutation + MAP2K1 mutation (1)

BRAF mutation + RAS mutation (1)

BRAF mutation + TERT −124C>T (1)

BRAF mutation + TERT −138CC>TT (1)

BRAF mutation + TERT −139CC>TT (1)

BRAF mutation + TERT −146C>T (1)

BRAF mutation + TET2 mutation (1)

BRAF mutation + TP53 mutation (1)

BRAF wild-type + NRAS wild-type (1)

EGFR T790M + BRAF V600E (1)

EGFR exon 19 deletion + BRAF V600E (1)

EGFR mutation + BRAF G469A (1)

EGFR mutation + BRAF mutation + TP53 mutation (1)

KRAS G12A + BRAF D549N (1)

KRAS G12V + BRAF V600E (1)

MAP2K1 V211D + BRAF mutation (1)

NRAS G12C + BRAF V600E + BRAF V600D (1)

NRAS G13D + BRAF V600E (1)

RAS wild-type + BRAF wild-type + MAP2K1 N57K (1)

ROS1 rearrangement + BRAF V600E (1)

TERT promoter mutation + BRAF V600 (1)

ARAF mutation + NRAS mutation (1)

ASXL1 mutation + NRAS mutation (1)

DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

DNMT3A mutation + NRAS mutation (1)

EGFR exon 20 insertion + NRAS G13V + NF1 R69fs + NF1 S340fs (1)

FLT3 mutation + NRAS mutation + PTPN11 mutation (1)

FLT3-ITD mutation + ASXL1 mutation + NRAS mutation (1)

FLT3-ITD mutation + DNMT3A mutation + NRAS mutation (1)

FLT3-ITD mutation + NRAS mutation + GATA2 mutation (1)

FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

HRAS Q61L + NRAS Q61K (1)

IDH2 mutation + NRAS mutation (1)

NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)

NPM1 mutation + NRAS mutation (1)

NPM1 mutation + SRSF2 mutation + FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

NRAS G115Efs*46 (1)

NRAS mutation + U2AF1 mutation (1)

SETBP1 mutation + NRAS mutation (1)

SRSF2 mutation + DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

TET2 mutation + NRAS mutation (1)

BRAF V600E + TERT mutation (0)

BRAF V600E + KRAS G12D (0)

BRAF V600E + MAP2K1 P124S (0)

BRAF exon 11 mutation (0)

BRAF exon 15 mutation (0)

CDKN2A mutation + BRAF V600E (0)

IDH mutation + BRAF V600E (0)

IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)

BRAF V600E (255)

BRAF mutation (129)

NRAS mutation (125)

BRAF V600 (106)

BRAF V600K (25)

BRAF wild-type (25)

RAS wild-type (17)

NRAS wild-type (10)

RAS wild-type + BRAF wild-type (7)

BRAF V600E + RNF43 mutation (6)

EGFR mutation + BRAF V600E (6)

BRAF V600E + PIK3CA mutation (4)

BRAF T1799A (3)

BRAF V600E + TERT mutation (3)

BRAF delNVTAP (3)

NRAS Q61K + BRAF V600E (3)

TERT mutation + BRAF V600E (3)

FLT3 mutation + NRAS mutation (3)

NRAS exon 2 mutation (3)

NRAS exon 4 mutation (3)

BRAF V600E + MAP2K1 I111S (2)

BRAF mutation + MEK1 P124L (2)

BRAF mutation + NF1 mutation (2)

BRAF rearrangement (2)

EGFR mutation + BRAF V600 (2)

IDH1 wild-type + BRAF mutation (2)

KRAS G13D + BRAF mutation (2)

MYD88 L265P + BRAF V600E (2)

NRAS G12C + BRAF mutation (2)

EGFR mutation + NRAS Q61K (2)

NRAS exon 3 mutation (2)

AKT1 E17K + BRAF V600 (1)

BRAF 486_490 del (1)

BRAF G466E + NF1 Y2285fs*5 + NF1 Y2640fs*3 + TP53 D281Y (1)

BRAF G466V + KIT K509Q (1)

BRAF N486-P490del + TP53 V157G (1)

BRAF V600 wild-type (1)

BRAF V600DK601del (1)

BRAF V600E + BRAF G469A + BRAF G469V (1)

BRAF V600E + BRAF K601_W604del (1)

BRAF V600E + BRAF L514V (1)

BRAF V600E + BRAF V600K (1)

BRAF V600E + KRAS G12R (1)

BRAF V600E + MSI-H/dMMR (1)

BRAF V600E + TERT E441del + RET N579K + EZH2 D154E + CDK4 S259L (1)

BRAF V600_K601delinsE (1)

BRAF mutation + EGFR mutation (1)

BRAF mutation + MAP2K1 mutation (1)

BRAF mutation + RAS mutation (1)

BRAF mutation + TERT −124C>T (1)

BRAF mutation + TERT −138CC>TT (1)

BRAF mutation + TERT −139CC>TT (1)

BRAF mutation + TERT −146C>T (1)

BRAF mutation + TET2 mutation (1)

BRAF mutation + TP53 mutation (1)

BRAF wild-type + NRAS wild-type (1)

EGFR T790M + BRAF V600E (1)

EGFR exon 19 deletion + BRAF V600E (1)

EGFR mutation + BRAF G469A (1)

EGFR mutation + BRAF mutation + TP53 mutation (1)

KRAS G12A + BRAF D549N (1)

KRAS G12V + BRAF V600E (1)

MAP2K1 V211D + BRAF mutation (1)

NRAS G12C + BRAF V600E + BRAF V600D (1)

NRAS G13D + BRAF V600E (1)

RAS wild-type + BRAF wild-type + MAP2K1 N57K (1)

ROS1 rearrangement + BRAF V600E (1)

TERT promoter mutation + BRAF V600 (1)

ARAF mutation + NRAS mutation (1)

ASXL1 mutation + NRAS mutation (1)

DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

DNMT3A mutation + NRAS mutation (1)

EGFR exon 20 insertion + NRAS G13V + NF1 R69fs + NF1 S340fs (1)

FLT3 mutation + NRAS mutation + PTPN11 mutation (1)

FLT3-ITD mutation + ASXL1 mutation + NRAS mutation (1)

FLT3-ITD mutation + DNMT3A mutation + NRAS mutation (1)

FLT3-ITD mutation + NRAS mutation + GATA2 mutation (1)

FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

HRAS Q61L + NRAS Q61K (1)

IDH2 mutation + NRAS mutation (1)

NF1 L581Ffs*6 + KRAS A146P + NRAS Q61K + TP53 R175H + PD-L1 T290M (1)

NPM1 mutation + NRAS mutation (1)

NPM1 mutation + SRSF2 mutation + FLT3-ITD mutation+ DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

NRAS G115Efs*46 (1)

NRAS mutation + U2AF1 mutation (1)

SETBP1 mutation + NRAS mutation (1)

SRSF2 mutation + DNMT3A mutation + ASXL1 mutation + NRAS mutation (1)

TET2 mutation + NRAS mutation (1)

BRAF V600E + TERT mutation (0)

BRAF V600E + KRAS G12D (0)

BRAF V600E + MAP2K1 P124S (0)

BRAF exon 11 mutation (0)

BRAF exon 15 mutation (0)

CDKN2A mutation + BRAF V600E (0)

IDH mutation + BRAF V600E (0)

IDH mutation + Chr del(1p) + Chr del(19q) + BRAF V600E (0)

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NRAS mutation + BRAF mutation	Colorectal Cancer	NRAS mutation + BRAF mutation	Colorectal Cancer	nivolumab Sensitive: C3 – Early Trials nivolumab Sensitive : C3	nivolumab Sensitive: C3 – Early Trials nivolumab Sensitive : C3
NRAS mutation + BRAF mutation	Ampulla of Vater Carcinoma	NRAS mutation + BRAF mutation	Ampulla of Vater Carcinoma	MEK inhibitor Sensitive: C4 – Case Studies MEK inhibitor Sensitive : C4	MEK inhibitor Sensitive: C4 – Case Studies MEK inhibitor Sensitive : C4
NRAS mutation + BRAF mutation	Non Small Cell Lung Cancer	NRAS mutation + BRAF mutation	Non Small Cell Lung Cancer	trametinib Resistant: D – Preclinical trametinib Resistant : D	trametinib Resistant: D – Preclinical trametinib Resistant : D
NRAS mutation + BRAF mutation	Melanoma	NRAS mutation + BRAF mutation	Melanoma	SCH772984 Sensitive: D – Preclinical SCH772984 Sensitive : D	SCH772984 Sensitive: D – Preclinical SCH772984 Sensitive : D