TEST:

Oncomine™ BCR Pan-Clonality Assay

7/9 patients had received therapy prior to transformation, including ibrutinib, acalabrutinib, or venetoclax. Targeted sequencing of a case series of CLL patients with RS revealed a clonal relationship in all nine cases. Multiple productive Ig rearrangements were identified in a surprising number of cases, consistent with a growing number of NGS studies support-ing greater diversity in CLL clonality than previously appreciated.

These results demonstrate the utility of a novel assay for combined repertoire analysis of B cell receptor heavy and light chains in a single library preparation reaction. We expect this assay to simplify workflow and inclusion of analysis tools such as automated somatic hypermutation rate determination and clonal lineage identification to open new paths for research in B cell disorders.

We expect this assay to simplify laboratory workflows and including analysis tools such as automated somatic hypermutation rate calculation and clonal lineage identification may open new paths for research in lymphoid cell disorders. For research use only.