The Oncomine BCR Pan-Clonality Assay is a targeted next-generation sequencing (NGS) assay for detection of B-cell heavy and light chain diversity to measure clonal expansion/contraction with accuracy and for detection of rare clones with high sensitivity. Primers have been specifically designed to target the FR3-J region of the IGH, IGK, and IGL rearrangements, as well as KDE and Cint-containing rearrangements.