The Ion Torrent Oncomine BCR IGH LR Assay is a robust, targeted next-generation sequencing (NGS) assay designed for use in hematology-oncology, immuno-oncology, infectious disease, and basic immunology research. Unlike other technologies, the Oncomine BCR IGH-LR Assay offers more than 400 base amplicons of library sequencing through long-read sequencing chemistry, enabling comprehensive coverage of the B-cell receptor (BCR) immunoglobin heavy (IGH) chain. The Oncomine BCR IGH LR Assay is designed to accurately measure clonal expansion, quantify somatic hypermutation, and isotype B lymphocytes using total RNA extracted from bone marrow, whole blood, peripheral blood leukocytes (PBLs), peripheral blood mononuclear cells (PBMCs), or sorted cells in fresh-frozen research specimens.