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TEST:
Archer® FusionPlex® Acute Lymphoblastic Leukemia (ALL)

Type:
Laboratory Developed Test
Related tests:
Evidence

News

2ms
TP53 (Tumor protein P53) • WT1 (WT1 Transcription Factor) • CD36 (thrombospondin receptor) • EP300 (E1A binding protein p300) • XIAP (X-Linked Inhibitor Of Apoptosis) • CDKN2C (Cyclin Dependent Kinase Inhibitor 2C)
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WT1 mutation
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Archer® FusionPlex® Acute Lymphoblastic Leukemia (ALL) • FusionPlex® Dx • LymphoTrack® Dx IGH Assay
5ms
Impact of Introducing Anchor ed Multiplex NGS Assays for the Detection of Novel Fusion Partners and Variants in Acute Lymphoblastic Leukemia, Lymphoma, and Sarcoma: Snapshot of a Cohort of Lebanese Patients (AMP Europe 2024)
The ability to detect these characteristic fusions ensures an accurate diagnosis and prognosis, and guides treatment decisions, molecular classificati on, and disease monitoring. Using NGS presents several advantages ov er standard testing methods, as it allows for the simultaneous analysis of multiple targets, thus saving time and testing material. It subsequently allows the incorporation of newly discovered biomarkers in the era of precision medicine.
Clinical • IO biomarker • Next-generation sequencing
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KRAS (KRAS proto-oncogene GTPase) • ALK (Anaplastic lymphoma kinase) • ABL1 (ABL proto-oncogene 1) • NRAS (Neuroblastoma RAS viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • NPM1 (Nucleophosmin 1) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • RUNX1 (RUNX Family Transcription Factor 1) • KMT2A (Lysine Methyltransferase 2A) • BCL6 (B-cell CLL/lymphoma 6) • ETV6 (ETS Variant Transcription Factor 6) • CRLF2 (Cytokine Receptor Like Factor 2) • IKZF1 (IKAROS Family Zinc Finger 1) • EWSR1 (EWS RNA Binding Protein 1) • PAX5 (Paired Box 5) • AFF1 (AF4/FMR2 Family Member 1) • JAK3 (Janus Kinase 3) • IRF8 (Interferon Regulatory Factor 8) • TCF3 (Transcription Factor 3) • PBX1 (PBX Homeobox 1) • FOXP1 (Forkhead Box P1) • EVI2B (Ecotropic Viral Integration Site 2B) • PAX3 (Paired Box 3)
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Archer® FusionPlex® Acute Lymphoblastic Leukemia (ALL)
almost2years
Integrated DNA Technologies Acquires ArcherDX Next Generation Sequencing Research Assays from Invitae Corporation (Integrated DNA Technologies Press Release)
"Integrated DNA Technologies, Inc....announced it closed on the purchase of Next Generation Sequencing (NGS) research assays from Invitae Corporation (NYSE: NVTA) under the trademarked name Archer. The integration of IDT’s portfolio with the acquired NGS research assays—which have been foundational in researching novel cancer fusions—will empower labs with an all-in-one solution to uncover biomarkers and advance cancer discoveries. The transaction enables IDT to expand its existing operations, build upon the legacy Archer portfolio, and welcome more than 100 new associates globally....Transaction Details-IDT purchased Archer NGS research assays—which reported high double-digit growth since 2019—from Invitae for cash consideration of approximately $48 million, subject to certain adjustments. The transaction is structured as an asset deal and includes a license to intellectual property related to the AMP technology."
M&A
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Archer® FusionPlex® Comprehensive Thyroid & Lung (CTL) Kit • Archer® FusionPlex® Acute Lymphoblastic Leukemia (ALL) • Archer® FusionPlex® Lung Kit • Archer® FusionPlex® Lymphoma • Archer® FusionPlex® Myeloid Kit • Archer® FusionPlex® Oncology Research Kit • Archer® FusionPlex® Sarcoma kit • Archer® VariantPlex® Comprehensive Thyroid and Lung (CTL) kit • Archer® VariantPlex® Myeloid panel • Archer® VariantPlex® Solid Tumor Kit • FusionPlex® Dx • FusionPlex® Pan Solid Tumor v2 panel • FusionPlex™ Heme v2 panel • FusionPlex™ Pan-Heme panel • LiquidPlex™