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DRUG:

ruserontinib (SKLB-1028)

i
Other names: SKLB-1028, SKLB1028, SKLB 1028
Associations
Company:
CSPC Pharma
Drug class:
EGFR inhibitor, Bcr-abl tyrosine kinase inhibitor, FLT3 inhibitor, Lyn protein-tyrosine kinase inhibitor
Related drugs:
Associations
7d
Evaluation of drug-drug interactions of a novel potent FLT3 inhibitor SKLB1028 in healthy subjects. (PubMed, Clin Transl Sci)
Based on the preclinical characterization of SKLB1028 metabolism, three drug-drug interaction clinical studies were performed to investigate the effects of itraconazole, rifampin (CYP3A4 inhibitor and inducer, respectively), and gemfibrozil (CYP2C8 inhibitor) on the metabolism of SKLB1028. Co-administration with rifampin reduced the AUC of SKLB1028 by ~30%, while the Cmax did not change significantly. All treatments were well tolerated in all three studies.
Journal
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FLT3 (Fms-related tyrosine kinase 3)
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FLT3-ITD mutation
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itraconazole • rifampicin • ruserontinib (SKLB-1028)
3years
ALIVE: A Study of SKLB1028 Versus Salvage Chemotherapy in Patients With Relapsed or Refractory (R/R) AML With FLT3-Mutated (clinicaltrials.gov)
P3, N=315, Recruiting, CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | Not yet recruiting --> Recruiting
Clinical • Enrollment open
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FLT3 (Fms-related tyrosine kinase 3)
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FLT3 mutation
|
cytarabine • azacitidine • fludarabine IV • Synribo (omacetaxine mepesuccinate) • aclarubicin • ruserontinib (SKLB-1028)
almost4years
Clinical • New P3 trial
|
FLT3 (Fms-related tyrosine kinase 3)
|
FLT3 mutation
|
cytarabine • azacitidine • fludarabine IV • Synribo (omacetaxine mepesuccinate) • aclarubicin • ruserontinib (SKLB-1028)