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DRUG:

Qinlock (ripretinib)

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News alerts, weekly reports and conference planners

Company:

Deciphera, GENESIS Pharma

Drug class:

c-KIT inhibitor, FLT3 inhibitor, PDGFR α inhibitor

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No biomarker	Gastrointestinal Stromal Tumor	No biomarker	Gastrointestinal Stromal Tumor	ripretinib Sensitive: A1 - Approval ripretinib Sensitive : A1	ripretinib Sensitive: A1 - Approval ripretinib Sensitive : A1
PDGFRA exon 18 mutation	Gastrointestinal Stromal Tumor	PDGFRA exon 18 mutation	Gastrointestinal Stromal Tumor	ripretinib Sensitive: A2 - Guideline ripretinib Sensitive : A2	ripretinib Sensitive: A2 - Guideline ripretinib Sensitive : A2
KIT mutation	Gastrointestinal Stromal Tumor	KIT mutation	Gastrointestinal Stromal Tumor	ripretinib Sensitive: B - Late Trials ripretinib Sensitive : B	ripretinib Sensitive: B - Late Trials ripretinib Sensitive : B
PDGFRA mutation	Gastrointestinal Stromal Tumor	PDGFRA mutation	Gastrointestinal Stromal Tumor	ripretinib Sensitive: B - Late Trials ripretinib Sensitive : B	ripretinib Sensitive: B - Late Trials ripretinib Sensitive : B
KIT exon 17 mutation	Gastrointestinal Stromal Tumor	KIT exon 17 mutation	Gastrointestinal Stromal Tumor	ripretinib Sensitive: B - Late Trials ripretinib Sensitive : B	ripretinib Sensitive: B - Late Trials ripretinib Sensitive : B
KIT exon 13 mutation	Gastrointestinal Stromal Tumor	KIT exon 13 mutation	Gastrointestinal Stromal Tumor	ripretinib Sensitive: B - Late Trials ripretinib Sensitive : B	ripretinib Sensitive: B - Late Trials ripretinib Sensitive : B
KIT exon 9 mutation	Gastrointestinal Stromal Tumor	KIT exon 9 mutation	Gastrointestinal Stromal Tumor	ripretinib Sensitive: B - Late Trials ripretinib Sensitive : B	ripretinib Sensitive: B - Late Trials ripretinib Sensitive : B
KIT exon 11 mutation	Gastrointestinal Stromal Tumor	KIT exon 11 mutation	Gastrointestinal Stromal Tumor	ripretinib Sensitive: B - Late Trials ripretinib Sensitive : B	ripretinib Sensitive: B - Late Trials ripretinib Sensitive : B
KIT exon 18 mutation	Gastrointestinal Stromal Tumor	KIT exon 18 mutation	Gastrointestinal Stromal Tumor	ripretinib Sensitive: B - Late Trials ripretinib Sensitive : B	ripretinib Sensitive: B - Late Trials ripretinib Sensitive : B
KIT mutation	Melanoma	KIT mutation	Melanoma	ripretinib Sensitive: C3 – Early Trials ripretinib Sensitive : C3	ripretinib Sensitive: C3 – Early Trials ripretinib Sensitive : C3
KIT amplification	Melanoma	KIT amplification	Melanoma	ripretinib Sensitive: C3 – Early Trials ripretinib Sensitive : C3	ripretinib Sensitive: C3 – Early Trials ripretinib Sensitive : C3