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DRUG:

mivavotinib (CB-659)

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Company:

Calithera

Drug class:

FLT3 inhibitor, SYK inhibitor

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FLT3 mutation + DNMT3A mutation	Acute Myelogenous Leukemia	FLT3 mutation + DNMT3A mutation	Acute Myelogenous Leukemia	CB-659 Sensitive: D – Preclinical CB-659 Sensitive : D	CB-659 Sensitive: D – Preclinical CB-659 Sensitive : D
FLT3 mutation + MLL mutation	Acute Myelogenous Leukemia	FLT3 mutation + MLL mutation	Acute Myelogenous Leukemia	CB-659 Sensitive: D – Preclinical CB-659 Sensitive : D	CB-659 Sensitive: D – Preclinical CB-659 Sensitive : D
FLT3 mutation + NPM1 mutation	Acute Myelogenous Leukemia	FLT3 mutation + NPM1 mutation	Acute Myelogenous Leukemia	CB-659 Sensitive: D – Preclinical CB-659 Sensitive : D	CB-659 Sensitive: D – Preclinical CB-659 Sensitive : D
MLL rearrangement	Acute Lymphocytic Leukemia	MLL rearrangement	Acute Lymphocytic Leukemia	CB-659 Sensitive: D – Preclinical CB-659 Sensitive : D	CB-659 Sensitive: D – Preclinical CB-659 Sensitive : D